Results 31 to 40 of about 1,031,287 (257)

Characterization of a Second Bovine Rotavirus Serotype [PDF]

, 1987
Bovine rotavirus (BRV) V 1005 was characterized by two-way cross-neutralization tests as a second serotype of BRV. Virions and inner shell particles of 65 nm and 55 nm diameter respectively, and empty capsids of 65 nm and 55 nm diameter were separated by
Fryder, V., Eichhorn, Werner, Marc-Martin, S., Sidoti, J., Büssow, Harald   +4 more
core   +2 more sources

Parainfluenza virus 5 genomes are located in viral cytoplasmic bodies whilst the virus dismantles the interferon-induced antiviral state of cells [PDF]

, 2009
This work was supported by the Wellcome Trust.Although the replication cycle of parainfluenza virus type 5 (PIV5) is initially severely impaired in cells in an interferon (IFN)-induced antiviral state, the virus still targets STAT1 for degradation.
Carlos, T S, Schneider, M, Simas, J P, Randall, Richard Edward, Young, Dan Frushard   +4 more
core   +1 more source

Synthesis and Evaluation of in Vitro Biological Activity of 4-Substituted Arylpiperazine Derivatives of 1,7,8,9-Tetrachloro-10,10-dimethoxy-4-azatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione

Molecules, 2009
A series of twenty arylpiperazine derivatives of 1,7,8,9-tetrachloro-10,10-dimethoxy-4-azatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione have been prepared. These derivatives were tested in vitro with the aim of identifying novel lead compounds active against ...
David Collu, Roberta Loddo, Cristina Ibba, Laura Ester Marongiu, Paolo La Colla, Izabela Dybala, Anna E. Koziol, Marta Struga, Jerzy Kossakowski, Magdalena Pakosinska-Parys   +9 more
doaj   +1 more source

Phylodynamic analysis of recent bovine viral diarrhea viruses in the Republic of Korea

Infection, Genetics and Evolution
Bovine viral diarrhea virus (BVDV) is a globally distributed and economically significant viral pathogen in the cattle industry. Despite ongoing circulation, molecular evolutionary and phylodynamic data on BVDV in the Republic of Korea (ROK) remain limited.
Hyung-Chul, Cho, Jaehyeok, Song, Kyoung-Seong, Choi   +2 more
openaire   +3 more sources

Ribonucleoside Analogue That Blocks Replication of Bovine Viral Diarrhea and Hepatitis C Viruses in Culture [PDF]

Antimicrobial Agents and Chemotherapy, 2003
ABSTRACT A base-modified nucleoside analogue, β- d -N 4 -hydroxycytidine (NHC), was found to have antipestivirus and antihepacivirus activities. This compound inhibited the production of cytopathic bovine viral diarrhea virus (BVDV) RNA in a dose-dependant manner with a 90 ...
Lieven J, Stuyver, Tony, Whitaker, Tamara R, McBrayer, Brenda I, Hernandez-Santiago, Stefania, Lostia, Phillip M, Tharnish, Mangala, Ramesh, Chung K, Chu, Robert, Jordan, Junxing, Shi, Suguna, Rachakonda, Kyoichi A, Watanabe, Michael J, Otto, Raymond F, Schinazi   +13 more
openaire   +2 more sources

Identification and Genetic Characterization of Viral Pathogens in Ruminant Gestation Abnormalities, Israel, 2015–2019

Viruses, 2021
Infectious agents including viruses are important abortifacients and can cause fetal abnormalities in livestock animals. Here, samples that had been collected in Israel from aborted or malformed ruminant fetuses between 2015 and 2019 were investigated ...
Natalia Golender, Velizar Bumbarov, Anita Kovtunenko, Dan David, Marisol Guini-Rubinstein, Asaf Sol, Martin Beer, Avi Eldar, Kerstin Wernike   +8 more
doaj   +1 more source

Detection and Characterization of Genetic Recombination in Cytopathic Type 2 Bovine Viral Diarrhea Viruses [PDF]

Journal of Virology, 2000
ABSTRACT In cytopathic bovine viral diarrhea virus genotype 1 (BVDV1) isolates, insertions are reported at position A (amino acid [aa] 1535) and position B (aa 1589). Insertions at position B predominate. In this survey it was found that in BVDV2, insertions at position A predominate. Possible reasons for this difference in relative frequency
J F, Ridpath, J D, Neill
openaire   +2 more sources

Molecular Dynamics‐Guided Sterol Engineering of mRNA‐Lipid Nanoparticles Reprograms Biodistribution and Enhances Spleen‐Selective Immunity

Advanced Science, EarlyView.
Sterol engineering enables precise control of mRNA lipid nanoparticles by tuning membrane organization. Replacing cholesterol with bile acid‐derived sterols redirects protein expression from the liver to the spleen. Notably, CA‐20 LNP enhances antigen‐specific immune responses while exhibiting a favorable safety profile, highlighting sterols as a ...
Sanghyuk Jeon, Seo‐Hyeon Bae, Jungyong Ji, Jisun Lee, Hosam Choi, Min‐Ho Kang, Sang‐In Park, Hyemin Kim, Nakyung Lee, Hajin Lee, Seonghoon Kim, Jungmin Kim, Subin Yoon, Seonghyun Lee, Seongje Cho, Dahyeon Ha, Ayoung Oh, Sohee Jo, Huijeong Choi, Yeeun Lee, Sowon Lee, Hyo‐Jung Park, Gitak Nam, Jisu Shin, Yujin Kang, Wonpil Im, Kiyoun Lee, Jae‐Hwan Nam   +27 more
wiley   +1 more source

Genetic diversity of bovine viral diarrhea viruses in commercial bovine serum batches of Chinese origin

Infection, Genetics and Evolution, 2014
Bovine viral diarrhea virus (BVDV) is often detected in commercial bovine serum. BVDV genetic diversity was investigated in commercial bovine serum of Chinese origin. Twenty-two batches of bovine serum were obtained from 10 suppliers with different geographic origins in China, and 20 batches of bovine serum were positive by reverse-transcription ...
Shu-Qin, Zhang, Bin, Tan, Li, Guo, Feng-Xue, Wang, Hong-Wei, Zhu, Yong-Jun, Wen, Shipeng, Cheng   +6 more
openaire   +2 more sources

SPSB1 Promotes Subcutaneous Adipose Hyperplasia in Facial Port‐Wine Stains by Controlling HDAC1 Degradation and Stability Through Two Distinct Proteolytic Pathways

Advanced Science, EarlyView.
In PWS‐ASPCs, FOSL1 drives the expression of SPSB1. SPSB1, as part of the ESC complex, further binds to HDAC1 and promotes K29‐linked and K48‐linked polyubiquitination of HDAC1. These modifications facilitate the degradation of HDAC1 through the ALP and UPS pathways, respectively.
Hongrui Chen, Bin Sun, Yajing Qiu, Chen Hua, Xiaoxi Lin, Wei Gao   +5 more
wiley   +1 more source