Results 51 to 60 of about 1,031,287 (257)

Structure and Function of a Multi‐Megadalton Virus‐Like Proteolytic Dodecahedron

Angewandte Chemie, EarlyView.
Zuzalysin, a virulence metallopeptidase of the periodontal pathogen Porphyromonas gingivalis, is secreted as a latent, flexible ≈95‐kDa monomer. Calcium triggers cysteine‐switch activation and hierarchical assembly into pentamers, bipentamers, tripentamers, and a ≈5.6‐MDa, ≈355‐Å dodecahedron. Structures at 1.8–3.6 Å reveal a virus‐sized catalytic cage
Mariusz Madej, Arturo Rodríguez‐Banqueri, Danuta Mizgalska, Borys Szmigielski, Zuzanna Nowakowska, Małgorzata Benedyk‐Machaczka, Monika Bzowska, Katarzyna Mikruta, Juan Sebastián Ramírez‐Larrota, Chinanu Agunanne, Olivier Julien, Anthony J. O'Donoghue, Carsten Scavenius, Mario López‐Martín, Enrique Marcos, Łukasz Koziej, Sebastian Glatt, Pablo Guerra, Ulrich Eckhard, Jan Potempa, F. Xavier Gomis‐Rüth   +20 more
wiley   +2 more sources

Evaluation of the effectiveness of the SurePure Turbulator ultraviolet-C irradiation equipment on inactivation of different enveloped and non-enveloped viruses inoculated in commercially collected liquid animal plasma.

PLoS ONE, 2019
The objective of this study was to evaluate the effectiveness of the SurePure Turbulator ultraviolet-C (UV-C, 254 nm wavelength) irradiation equipment on inactivation of different enveloped and non-enveloped viruses in commercially collected liquid ...
Elena Blázquez, Carmen Rodríguez, Jesús Ródenas, Núria Navarro, Cristina Riquelme, Rosa Rosell, Joy Campbell, Joe Crenshaw, Joaquim Segalés, Joan Pujols, Javier Polo   +10 more
doaj   +1 more source

Uhrf1‐Mediated PKM2 Degradation via Ubiquitination Alleviates Inflammation and Pyroptosis in Inflammatory Bowel Disease

Advanced Science, EarlyView.
Uhrf1‐mediated PKM2 ubiquitination and degradation repressed the nuclear translocation of PKM2, and EPT served as a molecular glue capable of targeting the Uhrf1–PKM2 complex to alleviate the IBD course, suggesting that the Uhrf1–PKM2 axis was a previously unrecognized strategy for treating IBD.
Juan Zhang, Xin‐Rong Xu, Hui‐Lin Zhang, Qi‐Meng Zhu, Xin‐Yuan Li, Xi‐Peng Shang, Jing‐Hui Du, Christophe Morisseau, Feng Qiu, Cheng‐Peng Sun   +9 more
wiley   +1 more source

Bovine Viral Diarrhea Virus Testing Options

, 2003
A review of bovine viral diarrhea virus (BVDV) dynamics is followed by a review of test efficiency measures. BVDV diagnostic challeneges are then discussed with attention to its pathogenesis during pregnancy and fetal effects.
Slenning, Barrett D.
core   +1 more source

Endemic cattle diseases : comparative epidemiology and governance [PDF]

, 2011
Cattle are infected by a community of endemic pathogens with different epidemiological properties which invoke different managerial and governmental responses. We present characteristics of pathogens that influence their ability to persist in the UK, and
McEldowney, John F., Matt Keeling, Carslake, David, Jonathan Cave, Graham F. Medley, Green, Laura E.; id_orcid, Keeling, Matt, Greaves, Justin, Medley, Graham F., David Carslake, Keeling, Matthew James, Laura E. Green, Cave, Jonathan, Weldegebriel, Habtu, Medley, Graham, Justin Greaves, McEldowney, John, Weldegebriel, Habtu Tadesse, Grant, Wyn, Green, Laura E., Habtu Weldegebriel, Cave, Jonathan A. K., John McEldowney, Wyn Grant   +23 more
core   +1 more source

Metagenomic insights into the complex viral composition of the enteric RNA virome in healthy and diarrheic calves from Ethiopia

Virology Journal
Background Viruses and the virome have received increased attention in the context of calf diarrhea and with the advancement of high-throughput sequencing the detection and discovery of viruses has been improved. Calf diarrhea, being the main contributor
Julia Bergholm, Tesfaye Sisay Tessema, Anne-Lie Blomström, Mikael Berg   +3 more
doaj   +1 more source

Viral Diseases in Water Buffalo (Bubalus bubalis): New Insights and Perspectives

Animals
The water buffalo (Bubalus bubalis) has great adaptability to rustic environments and more variable conditions than cattle, who generally share the habitat.
Julio Martínez-Burnes, Hugo Barrios-García, Verónica Carvajal-de la Fuente, Belkis Corona-González, Dasiel Obregón Alvarez, Dora Romero-Salas   +5 more
doaj   +1 more source

Targeting the CRYAB/β‐Catenin Axis with an MMP‐9‐Responsive Hydrogel Disrupts CTC Clusters to Suppress Progression of Hepatocellular Carcinoma after Radiofrequency Ablation

Advanced Science, EarlyView.
The graphical abstract illustrates that sublethal thermal stress after iRFA upregulates the chaperone CRYAB in residual HCC cells, which stabilizes β‐catenin and drives a dual pathological program, including EMT and N2‐TAN polarization, thereby leading to heterotypic CTC cluster formation. The MMP‐9‐responsive hydrogel (XB@Gel) delivers XAV‐939 and BMS‐
Hui Chen, Danni Yang, Songying Pi, Yuhan Liu, Hongbin Huang, Feile Ye, Yuhong Lin, Zhongzhen Su, Yongquan Huang   +8 more
wiley   +1 more source

Importance of Viral Disease in Dairy Cow Fertility

Engineering, 2020
Many viral diseases are endemic in cattle populations worldwide. The ability of many viruses to cross the placenta and cause abortions and fetal malformations is well understood.
D. Claire Wathes, Chike F. Oguejiofor, Carole Thomas, Zhangrui Cheng   +3 more
doaj   +1 more source

Genetic Typing of Bovine Viral Diarrhea Viruses (BVDV) Circulating in Korea

Journal of Bacteriology and Virology, 2007
To characterize the genetic diversity of bovine viral diarrhea viruses (BVDV) circulating in Korea, 11 BVDV isolates were obtained from 467 field samples collected during 2005~2006 in Korea. All of the BVDV isolates were identified as non-cytopathic (non-cp) BVDV biotypes. The 5' noncoding region (NCR) genes of the isolates were sequenced and analyzed.
Dong-Kun Yang, Byoung-Han Kim, Chang-Hee Kweon, Jeong-Kyu Park, Ha-Young Kim, Byung-Jae So, In-Joong Kim   +6 more
openaire   +1 more source