Results 101 to 110 of about 1,117 (151)

Protocol for a phase 2, partially blinded, randomized trial assessing the safety and efficacy of sorfequiline or bedaquiline in combination with pretomanid and linezolid in adult participants with newly diagnosed, drug-sensitive, smear-positive pulmonary tuberculosis (NC-009). [PDF]

Trials
Olugbosi M, Beumont M, Lombard L, Nedelman J, Timm J, Black T, Bruning-Barry R, Hickman D, Lombardi A, Betteridge M, Egizi E, Marcopulos L, Henderson J, Seidel S, Foraida S, Benhayoun M, Sun E.   +16 more
europepmc   +1 more source

Investigation of delamanid, bedaquiline, and linezolid resistance rates and related gene mutations in multidrug-resistant Mycobacterium tuberculosis in regional tuberculosis reference laboratories of Iran. [PDF]

BMC Microbiol
Ahmad Khosravi N, Khosravi AD, Hashemzadeh M, Savari M, Saki M.   +4 more
europepmc   +1 more source

Bedaquiline and linezolid regimens for multidrug-resistant tuberculosis: a systematic review and meta-analysis. [PDF]

J Bras Pneumol
Cheraghi M, Amiri M, Andarzgoo S, Zarei F, Seghatoleslami ZS, Centis R, Visca D, D'Ambrosio L, Pontali E, Nasiri MJ, Migliori GB.   +10 more
europepmc   +1 more source

The Frequency and Incidence of QT Prolongation With Extended Use of Bedaquiline or Delamanid in a Large, Multi-Country Multidrug-Resistant/Rifampicin-Resistant Tuberculosis Cohort. [PDF]

Clin Infect Dis
Khan U, Rich M, Franke MF, Lachenal N, Ahmed S, Bekele A, Isani AK, Hewison C, Sari CYI, Tan CL, Varaine F, Flores EH, Putri FA, Faqirzai J, Beauchamp J, Vo LNQ, Siddiqui MR, Seung K, Bastard M, Nkunkanyirazo P, Kiria N, Khan M, Algozhin Y, Melikyan N, Saki NA, Vilbrun SC, Fatima R, Naing YY, Islam S, Mamsa S, Mitnick CD, Huerga H, Khan PY.   +32 more
europepmc   +1 more source

A novel one-tube nested fluorescence melting curve analysis for rapid detection of drug-resistant Mycobacterium tuberculosis. [PDF]

BMC Microbiol
Chang Y, Liu G, Li X, Zhang M, Diao T, Yang C, Wu X, Tu Y, Zhang H, Zhou C, Lei P, Liu L, Xia X, Feng Y.   +13 more
europepmc   +1 more source

Bedaquiline-induced psoriasiform drug eruption in a patient of multidrug-resistant tuberculosis.

Indian J Pharmacol
Kowe P, Zatakia S, Chethan MV, Dhurat R.
europepmc   +1 more source

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Iron‐MOF‐Catalyzed Domino Cyclization and Aromatization Strategy for the Synthesis of 2,4‐Diarylquinolines

Asian Journal of Organic Chemistry, 2020
AbstractAn iron‐based metal‐organic framework, Fe(BTC) has been used as an efficient heterogeneous and sustainable catalyst for the synthesis of 2,4‐diarylquinolines via three‐component Povarov reaction. The presence of a high concentration of coordinatively unsaturated Fe3+ sites of Fe(BTC) efficiently catalyzes the formation of diarylquinolines in ...
Nainamalai Devarajan, Palaniswamy Suresh   +1 more
exaly   +3 more sources

Diarylquinolines, Synthesis Pathways and Quantitative Structure–Activity Relationship Studies Leading to the Discovery of TMC207

Future Medicinal Chemistry, 2011
The emergence of multidrug-resistant strains of Mycobacterium tuberculosis and resistance to current anti-TB drugs call for the discovery and development of new effective anti-TB drugs. TMC207 is the lead candidate of a novel class of antimycobacterial agents, the diarylquinolines, which specifically inhibit mycobacterial ATP synthase and displays high
Jérôme Guillemont, Koen Andries
exaly   +5 more sources

Toxicological properties of a new anti-tuberculosis drug from the group of diarylquinolines

Pharmateca, 2022
A Yu Savchenko, V G Kukes
exaly   +3 more sources

Metal‐Free and Mild Synthesis of 2,4‐Diarylquinolines

European Journal of Organic Chemistry, 2023
AbstractWe have developed a useful method to synthesize quinoline derivatives, which required no transition metals, no peroxides, and no high temperatures. This method provides a novel and gentle synthetic route for various multifunctional 2,4‐diarylquinolines with good yields.
Chen Ma
exaly   +2 more sources