Results 111 to 120 of about 1,117 (151)

ESKAPE Pathogens: Structure-Activity Relationships of 24-Diarylquinolines

2021
Drug resistance by persisters is a global issue that requires urgent attention. Quinolines and quinolones have proven to be important cores in several bioactive organic chemotypes, based on this, the antimicrobial activity of six derivatives of 2,4-diarylquinolines was evaluated using the disc diffusion method at 5-20 µM/mL.
K. A. Oluwafemi
openaire   +2 more sources

Diarylquinolines target subunit c of mycobacterial ATP synthase

Nature Chemical Biology, 2007
The diarylquinoline R207910 (TMC207) is a promising candidate in clinical development for the treatment of tuberculosis. Though R207910-resistant mycobacteria bear mutations in ATP synthase, the compound's precise target is not known. Here we establish by genetic, biochemical and binding assays that the oligomeric subunit c (AtpE) of ATP synthase is ...
Koul, Anil, Dendouga, Najoua, Vergauwen, Karen, Molenberghs, Brenda, Vranckx, Luc, Willebrords, Eudy, Ristic, Zorica, Lill, Holger, Dorange, Ismet, Guillemont, Jerome, Bald, Dirk, Andries, Koen   +11 more
openaire   +5 more sources

MeOTf-induced annulation of arylisocyanates and arylalkynes leading to 4-methoxyl-2,3-diarylquinolines

Tetrahedron Letters, 2018
MeOTf-induced one-pot method for the synthesis of a series of 4-methoxylquinolones has been descripted. This route provides a practical and convenient method for the synthesis of 4-methoxylquinolones from readily available starting materials under metal ...
Chanjuan Xi
exaly   +2 more sources

N-heterocyclic carbene (NHC)-modulated Pd/Cu cocatalyzed three-component synthesis of 2,6-diarylquinolines

Organic and Biomolecular Chemistry, 2014
Chen Xu, Zhi-Qiang Xiao, Wei-Jun Fu
exaly   +2 more sources

Chemoselective Synthesis and Human Ecto‐5′‐nucleotidase Inhibitory Activity of 2‐Trifluoromethyl‐4,6‐diarylquinolines

ChemistrySelect, 2018
Sidra Hassan, Peter Ehlers, Joanna Lecka   +2 more
exaly   +2 more sources

Synthesis of 2,3-Diarylquinolines via Trapping of the Vinyl Metal Intermediate

Synfacts, 2018
P. Knochel, Dorothée S. Ziegler
openaire   +2 more sources

SmI2-mediated facile one-pot preparation of 2,4-diarylquinolines from 3-aryl-2,1-benzisoxazoles

Tetrahedron Letters, 2002
Xuesen Fan, Yongmin Zhang
exaly   +3 more sources

Synthesis of 2,4-Diarylquinolines: Nickel-Catalysed Ligand-Free Cross-Couplings of 4-Chloro-2-Arylquinolines with Arylmagnesium Halides in 2-Methyltetrahydrofuran

Journal of Chemical Research, 2011
Zhenhua Li
exaly   +2 more sources

Novel synthesis of 2,4-diarylquinolines by photochemical followed by thermal transformations of 1,4,6-triarylpyrimidin-2(1H)-ones

Journal of the Chemical Society Perkin Transactions 1, 1983
Takehiko Nishio, Yoshimori Omote
exaly   +2 more sources

Synthesis and antiproliferative evaluation of 2,3-diarylquinoline derivatives

Organic & Biomolecular Chemistry, 2011
A number of 2,3-diarylquinoline derivatives were synthesized and evaluated for antiproliferative activities against the growth of six cancer cell lines including human hepatocellular carcinoma (Hep G2 and Hep 3B), non-small cell lung cancer (A549 and H1299), and breast cancer (MCF-7 and MDA-MB-231) cell lines.
Chih-Hua, Tseng, Yeh-Long, Chen, Kuin-Yu, Chung, Chi-Huei, Wang, Shin-I, Peng, Chih-Mei, Cheng, Cherng-Chyi, Tzeng   +6 more
openaire   +2 more sources