Results 171 to 180 of about 20,067 (277)

Trifluoromethylation‐Induced Lactonization: A Novel Transformation of Unsaturated Carboxylic Acids

ChemistryOpen, Volume 15, Issue 8, August 2026.
Fluorinated drugs often contain trifluoromethyl groups. The increasing importance of such drugs has resulted in more and more attention toward new or improved trifluoromethylation reactions. This review discusses possible reaction mechanisms and existing methods for one such process, trifluoromethylation‐induced lactonization, a distant relative of the
Attila M. Remete
wiley   +1 more source

Diastereodivergent electrophilic trapping of α-boryl lithium derivatives. [PDF]

Beilstein J Org Chem
Pavlíčková T, Orbach N, Marek I.
europepmc   +1 more source

S‐Adenosyl‐d‐Methionine as a Non‐Physiological Substrate for a Wide Range of SAM‐Dependent Enzymes

ChemBioChem, Volume 27, Issue 14, 29 July 2026.
From methylation and cyclisation to radical chemistry, diverse enzyme classes utilise the non‐canonical cofactor d‐SAM. These findings reveal an unexpected tolerance of SAM‐dependent catalysis towards inversion of the methionine Cα stereocentre. The ability of SAM‐dependent enzymes to accept S‐adenosyl‐d‐methionine [d‐SAM, (SS,RCα)‐SAM] instead of the ...
Philipp Germer, Lukas Gericke, Lars‐Hendrik Koeppl, Ziruo Zou, Emely Jockmann, Marco Kuge, Katrin Zoller, Hannah Herrmann, Ronja Fuderer, Michael K. F. Mohr, Agnes Bartels, Göksu Oral, Peer Lukat, Gunhild Layer, Michael Müller, Wulf Blankenfeldt, Lena Barra, Jennifer N. Andexer   +17 more
wiley   +1 more source

Liquid chromatographic determination of enantiomeric purity of [¹¹C]methyl-L-methionine and O-(2-[¹⁸F]fluoroethyl)-L-tyrosine by pre-column derivatization with o-phthaldialdehyde and N-isobutyryl-L-cysteine. [PDF]

EJNMMI Radiopharm Chem
Forgács V, Balla V, Csonka V, Szikra D, Szücs D, Németh E, Képes Z, Trencsényi G, Jószai I.   +8 more
europepmc   +1 more source

Acyclic Hydrocarbon α,ω‐Dienes: From Biomass and Plastic Upcycling to Carbocycles, Precision Polymers, and Cross‐Linked Elastomers

ChemSusChem, Volume 19, Issue 14, 29 July 2026.
Hydrocarbon α,ω‐dienes are mainly produced from steam‐cracking derivatives, but high costs, complexity, and environmental impact limit their use. This review highlights sustainable paths from biomass and plastic upcycling, and surveys catalytic transformations into carbocycles and specialty polymers, emphasizing their role as modular building blocks ...
Rosa Villaccio, Giuseppe Leone
wiley   +1 more source

Control over stereogenic centres beyond tetracoordination. [PDF]

Chem Sci
Budeev A, Sparr C.
europepmc   +1 more source

Late‐Stage Functionalization of Peptides on the Solid Phase

Angewandte Chemie International Edition, Volume 65, Issue 31, 27 July 2026.
Peptide modifications are essential to control pharmacodynamic and pharmacokinetic properties of peptide drugs. Consequently, strategies that allow for efficient and rapid incorporation of non‐canonical modifications into peptides in parallel formats are highly sought after.
Marius Werner, Truc Lam Pham, Franziska Thomas   +2 more
wiley   +1 more source

Macrocyclic oxygen transfer in the conversion of fatty acid hydroperoxide to a single species of triol in physiological saline.

Org Biomol Chem
Choi MS, Boeglin WE, Stec DF, Calcutt MW, Porter NA, Brash AR.   +5 more
europepmc   +1 more source

Imidazol-2-ylidene-Based NCCN Ligands for Chiral-at-Iron Catalysis. [PDF]

Organometallics
Hinterlang L, Ivlev SI, Meggers E.
europepmc   +1 more source

Methyl on the Bridge: 2‐Methyl Propellane as Precursor for 1,3‐Substituted 2‐Methylated Bicyclo[1.1.1]Pentanes

Chemistry – A European Journal, Volume 32, Issue 28, 25 July 2026.
The synthesis of 2‐methyl propellane and its conversion to various 1,2‐ and 1,2,3‐di‐ and trisubstituted bicyclopentanes is reported. Abstract Bicyclo[1.1.1]pentanes (BCPs) have emerged as isosteric replacements for mono‐ and para‐substituted benzene rings in medicinal and materials applications, involving substitution at the BCP bridgehead (1,3 ...
Sean R. Verschaeve, Mariana Gomes Manso, Tibo Van Eeckhoorn, Mark E. Light, Bruno Linclau   +4 more
wiley   +1 more source