Results 161 to 170 of about 20,067 (277)

Rh-Catalyzed Chemodivergent Parallel Kinetic Resolution and Desymmetrization of Enynes and Dienynes with Acrylamides. [PDF]

Angew Chem Int Ed Engl
Hamada S, Jiang J, Sato Y, Yamazaki T, Maeda S, Tanaka K.   +5 more
europepmc   +1 more source

Diastereomeric Branched-Ester dBET1 Analogs Exhibit Conformation-Dependent Differences in Passive Membrane Permeability. [PDF]

J Med Chem
Abdelwahid MAS, Hayakawa E, Hirai K, Ishii M, Kanamitsu K, Yasuda S, Ohtake F, Sato S, Tomoshige S, Ishikawa M.   +9 more
europepmc   +1 more source

Phosphodiesterase 9 (PDE9) Inhibitors May Provide Effective Treatments for Neurodegenerative, Cardiovascular and Other Diseases. [PDF]

ACS Med Chem Lett
Abdel-Magid AF.
europepmc   +1 more source

Bioinspired Collective Synthesis of Gymnothelignans I, F, K, and L. [PDF]

J Org Chem
Chumsri N, Chualong K, Chairoungdua A, Kuhakarn C, Leowanawat P, Reutrakul V, Soorukram D.   +6 more
europepmc   +1 more source

Chemoenzymatic Synthesis of Chiral Piperidines Using the Immobilized Transaminase ATA‐117 in Continuous Flow Reactors

Advanced Synthesis &Catalysis, Volume 368, Issue 15, 1 August 2026.
A robust continuous flow chemoenzymatic process was developed for the stereoselective synthesis of cis‐(2R,6R)‐2,6‐disubstituted piperidines, including the natural alkaloid (–)‐pinidinone. The asymmetric transamination of α,β‐unsaturated ketones was catalyzed by immobilized ATA‐117, followed by spontaneous aza‐Michael cyclization, providing the desired
Sara Vicinanza, Ilaria Magrini Alunno, Stefania Patti, Morena Pirotta, Francesca Annunziata, Raffaella Gandolfi, Paola Conti, Chiara Borsari, Ivan Bassanini, Erica Elisa Ferrandi, Daniela Monti, Lucia Tamborini   +11 more
wiley   +1 more source

Competitive cyclization of ethyl trifluoroacetoacetate and methyl ketones with 1,3-diamino-2-propanol into hydrogenated oxazolo- and pyrimido-condensed pyridones. [PDF]

Beilstein J Org Chem
Kushch SO, Goryaeva MV, Burgart YV, Ezhikova MA, Kodess MI, Slepukhin PA, Volobueva AS, Zarubaev VV, Saloutin VI.   +8 more
europepmc   +1 more source

In Vitro Metabolism of Δ8‐, Δ9‐, and Δ10‐THC in Human Hepatocytes: Distinct Δ10‐THC Biotransformation and Implications for Drug Testing

Drug Testing and Analysis, Volume 18, Issue 8, Page 1114-1121, August 2026.
Δ8‐THC and Δ9‐THC showed comparable metabolic profiles. In contrast, Δ10‐THC underwent extensive glucuronidation and hydroxylation, with only minor formation of a carboxy metabolite, indicating a markedly different metabolic pathway. These differences may increase the risk of misidentification and misinterpretation in cannabis drug testing.
Robert Kronstrand, Henrik Green, Markus Loh, Fabian Rüttimann, Manuela Carla Monti   +4 more
wiley   +1 more source

Separation of PS diastereomers in GalNAc-conjugated siRNA-a comparative study of chromatographic and ion mobility mass spectrometry approaches. [PDF]

Anal Bioanal Chem
Bill MK, Graglia M, Riley JA, Zugaj M, Demtschenko N, Fox J, Bethge L, Smink JJ, Manz C.   +8 more
europepmc   +1 more source

Designing chiral organic small molecules for circularly polarized light detection via group theory

InfoMat, Volume 8, Issue 8, August 2026.
The chiral point group determines the arrangement of the μ‐m of chiral organic small molecules, thereby influencing their chiral photoelectric properties. In particular, chiral molecules with the D2 point group can effectively align the μ‐m to be either 0° or 180°, an effective strategy for high‐performance circularly polarized light photodetectors ...
Zhenping Li, Wenkai Zhao, Jiajun Fu, Wenhan Wu, Xingshuo Chu, Zihao Xu, Yu‐Wu Zhong, Hao‐Li Zhang, Wei Ma, Guankui Long, Xiaobo Shang   +10 more
wiley   +1 more source

Chirally locked and dynamic bis-perylene diimide macrocycles with multiple sources of chirality. [PDF]

Commun Chem
Hartmann D, Penty SE, Pal R, Barendt TA.
europepmc   +1 more source