Rapid Communications in Mass Spectrometry, EarlyView.Rationale Mass spectrometry (MS) is introduced to high school students in the UK in many pre‐university course syllabi. As such, we have identified the use of MS as a key technique that should be taught practically to undergraduates from the outset of their studies.
Andrew F. Worrall +3 more
wiley +1 more source
Mechanistic Insights into Regioselective Arene Insertion Using Bis(phosphine) Cobalt(I) Hydrides to Form 1,3-Cyclohexadienes. [PDF]
OrganometallicsLebowitz MJ +5 more
europepmc +1 more source
Best practices in `0 K' DFT energy calculations on molecular crystal structures
Acta Crystallographica Section C, EarlyView.This article describes best practices for `zero Kelvin' energy calculations on molecular crystals and is targeted for non‐experts who would like to perform their own calculations or assess the accuracy and validity of such calculations reported in the scientific literature.This article describes best practices for `zero Kelvin' energy calculations on ...
Jacco van de Streek, Erin R. Johnson
wiley +1 more source
Effect of Stereochemistry on the Antiplasmodial Activity and Metabolomic Profile of Novel Tadalafil Analogues. [PDF]
ACS Med Chem LettElhalawaty EA +10 more
europepmc +1 more source
S‐Adenosylmethionine (SAM) hydrolases counter increased SAM epimerisation in thermophilic archaea
The FEBS Journal, EarlyView.S‐Adenosyl‐l‐methionine (SAM) is a vital enzyme cofactor. Epimerisation at the sulfonium centre of biologically active (SS,SCα)‐SAM is driven by heat, yielding biologically inactive (RS,SCα)‐SAM. Here, two novel archaeal SAM hydrolases from the thermophilic Sulfolobus acidocaldarius and the halophilic Haloferax volcanii are shown to cleave (RS,SCα)‐SAM.
Agnes Bartels +7 more
wiley +1 more source
Angewandte Chemie, Volume 138, Issue 32, 3 August 2026.An enantioselective rhodium‐catalyzed [2 + 2 + 2] cycloaddition enables the synthesis of axially chiral diaryl ethers. Carbonyl coordination ensures high reactivity and regioselectivity, affording products bearing up to four stereogenic axes with good enantio‐ and diastereoselectivity.
Yu Sato +3 more
wiley +2 more sources
Amplified chiroptic response in a multi-helical penta-perylene structure. [PDF]
Chem SciPedersen SK +3 more
europepmc +1 more source
The tryptophan prenyltransferase ComQ from Bacillus subtilis 168 can prenylate daptomycin at Trp1
The FEBS Journal, EarlyView.ComQ168 from Bacillus subtilis 168 catalyzes C‐terminal tryptophan farnesylation of ComX to generate a competence‐inducing pheromone. Recombinant ComQ168 also modifies cyclic peptides, including Daptomycin, likely at the N‐terminal tryptophan. Structural modeling highlights a C‐terminal binding region, supporting substrate promiscuity and establishing ...
Yanli Xu +2 more
wiley +1 more source
Asymmetric Iron‐Catalyzed Vicinal C(sp3)─H Diamination of Carboxylic Acids
Angewandte Chemie, Volume 138, Issue 32, 3 August 2026.An iron‐catalyzed vicinal α,β‐C(sp3)─H diamination of readily available carboxylic acids furnishes chiral α,β‐diamino acids in a single pot with high regio‐, diastereo‐, and enantioselectivity (up to >20:1 dr and >99% ee). ABSTRACT The direct construction of chiral 1,2‐diamines through the stereoselective functionalization of two vicinal C(sp3)─H bonds
Bing Zhou +5 more
wiley +2 more sources
Asymmetric Total Synthesis and Structure Revision of (+)-Mangicol D. [PDF]
J Am Chem SocXie Y +4 more
europepmc +1 more source