Results 131 to 140 of about 14,574 (240)

Characterizing the Elemental Metabolome in Asparagus officinalis with Multielemental Speciation Analysis. [PDF]

open access: yesJ Agric Food Chem
Milovanovic I   +4 more
europepmc   +1 more source

Synthesis and Evaluation of Peptoid‐Based Compound Libraries as Inhibitors of Parasite Metallo‐Aminopeptidases

open access: yesChemMedChem, Volume 21, Issue 17, 14 September 2026.
Evaluation of two libraries of peptoid‐based compounds for inhibitory activity against PfA‐M1 from Plasmodium falciparum, TcLAP from Trypanosoma cruzi, and LmLAP from Leishmania major reveals the crucial role of hydrophobic interactions in the inhibition process of these parasite metallo‐aminopeptidases.
Mirta Elisa Aguado   +16 more
wiley   +1 more source

Redefining Fluoroquinolone Antibiotics: Design and Synthesis of Degradable Fluoroquinolones to Reduce Environmental Persistence

open access: yesChemSusChem, Volume 19, Issue 17, 14 September 2026.
Redesign and development of an efficient, robust synthesis platform for environmentally improved fluoroquinolones. A significant challenge associated with antibiotics, and active pharmaceutical ingredients in general, is their intentional design for high stability, which promotes environmental persistence and contributes to the development of ...
Nathan Raeymackers   +6 more
wiley   +1 more source

Catalytic Generation of Cationic Gold Carbene Complexes From 7‐Alkynylnorbornadienes and Their Intermolecular Cyclopropanation With Alkenes

open access: yesChemistry – A European Journal, Volume 32, Issue 34, 11 September 2026.
Efficient cationic gold(I)‐catalyzed intermolecular cyclopropanation of 7‐alkynylnorbornadiene derivatives has been developed. This methodology offers the synthesis of a new class of norbornene derivatives in high yield with excellent diastereoselectivity.
Kento Ishida   +3 more
wiley   +1 more source

Harnessing the Reactivity of Sulfinate Salts With Cystine: An Umpolung Approach to Residue‐Specific Peptide Modification

open access: yesAngewandte Chemie, Volume 138, Issue 37, 7 September 2026.
While cysteine is widely employed as a nucleophilic handle for peptide modification, the electrophilicity of the oxidized form, cystine, is rarely exploited. This study describes a mild, photochemical coupling of sulfinate salts with peptide disulfides.
Joshua M. Hammond   +7 more
wiley   +2 more sources

Covalent Insertion of a Mn(Salen) Type Complex in Cross‐Linked Protein Crystals: Design of an Enantioselective Artificial Epoxidase

open access: yesChemistry – A European Journal, Volume 32, Issue 34, 11 September 2026.
An Artificial metalloenzyme was designed by a Michael addition between a MnSalen complex and a cysteine residue within NikA crystals. The heterogeneous catalyst was found capable of an enantioselective and stereospecific epoxidation of cis‐β‐methylstyrene in cristallo.
Manel Boukhallat   +8 more
wiley   +1 more source

Home - About - Disclaimer - Privacy