Results 111 to 120 of about 14,574 (240)

Development of 2‑Methyl-5-phenylpyrrolidine-Based ST2 Inhibitors for Neuroinflammatory Conditions. [PDF]

ACS Med Chem Lett
Yuan X, Cho EB, Patil AD, Aktaruzzaman M, Ramaraju A, Jiang C, Wang M, He M, Robida A, Wen B, Sun D, Rech JC, Jiang J, Yang CY.   +13 more
europepmc   +1 more source

Modular Synthesis of α‐Quaternary Pyrrolines by Pyridoxal‐Catalyzed Sequential Reactions With Precise Chirality Relay

Transformative Chemistry, EarlyView.
Direct asymmetric α‐C conjugate addition of aminoacetonitrile enabled by carbonyl/iminium double activation, together with subsequent electrophilic functionalization, offers a one‐pot, two‐step modular strategy for synthesizing chiral α‐quaternary pyrrolines with precise chirality relay and high structural diversity.
Xingdie Yang, Pengwei Ji, Liang Liu, Tongyin Chen, Siqi Liu, Wen‐Wen Chen, Baoguo Zhao   +6 more
wiley   +1 more source

Chiral 3-acyl-2-pyrrolines as strategic hubs toward polycyclic pyrrolidines <i>via</i> enantioselective silver-catalyzed Michael addition-cyclization. [PDF]

Chem Sci
Sakai S, Maeda K, Shimizu Y, Sawamura M.
europepmc   +1 more source

Oxaziridines: Versatile Reagents in Modern Organic Synthesis

The Chemical Record, EarlyView.
Being capable of transferring an O atom and N‐group/atom, oxaziridines are considered multitasking agents. These are employed for diverse organic transformations, such as epoxidation of olefins, α‐ and γ‐hydroxylation/amination of carbonyl compounds, oxidation of sulfides, [3+2]cycloaddition with unsaturated systems.
Ajeet Chandra, Subba Rao Cheekatla, Keshaba Nanda Parida   +2 more
wiley   +1 more source

A Stereoconvergent Annulation in the Synthesis of Lysergic Acid. [PDF]

Synthesis (Stuttg)
Firestone ZD, Harbit RC, Smith JM.
europepmc   +1 more source

2D and 3D Nets by Self‐Assembly of Carbosilane Functionalized Polyphilic Liquid Crystals

Zeitschrift für anorganische und allgemeine Chemie, EarlyView.
In the shown compounds, the growing volume of the carbosilane side‐groups modifies the self‐assembly in liquid crystalline phases ranging from a square via a pentagonal to a hexagonal honeycomb and finally to a 3D (10,3)‐a double net. The structures are discussed in relation to inorganic solid‐state materials and the concept of “mesoatoms”.
Christian Anders, Matthias Wagner, Silvio Poppe, Carsten Tschierske   +3 more
wiley   +1 more source

Protonation‐Gated Orthogonal Control of Highly Efficient Molecular Motors With Broad Visible‐Light Responsiveness

Angewandte Chemie, Volume 138, Issue 38, 14 September 2026.
Reversible protonation gates coumarin‐based overcrowded‐alkene molecular motors by dynamically reshaping their conjugation topology. This strategy enables efficient, near‐quantitative unidirectional photoisomerization from blue–green to red‐shifted visible light up to 600 nm, while preserving motor function and allowing orthogonal light, heat, and acid/
Jinghao Wang, Alexander Ryabchun, Ben L. Feringa   +2 more
wiley   +2 more sources

Fluorinated Aminopiperidones as Non-Glutarimide Thalidomide Analogs: Stereodivergent Synthesis and Validation. [PDF]

ChemMedChem
Adamlje B, Tomašič T, Steinebach C, Ebeling S, Herrmann A, Hartmann MD, Horner JL, Bhadresha K, Chau CH, Figg WD, Sosič I, Cotman AE.   +11 more
europepmc   +1 more source

S‐Adenosylmethionine (SAM) hydrolases counter increased SAM epimerisation in thermophilic archaea

The FEBS Journal, EarlyView.
S‐Adenosyl‐l‐methionine (SAM) is a vital enzyme cofactor. Epimerisation at the sulfonium centre of biologically active (SS,SCα)‐SAM is driven by heat, yielding biologically inactive (RS,SCα)‐SAM. Here, two novel archaeal SAM hydrolases from the thermophilic Sulfolobus acidocaldarius and the halophilic Haloferax volcanii are shown to cleave (RS,SCα)‐SAM.
Agnes Bartels, Michael K. F. Mohr, Phillip Nußbaum, Marie Joest, Bianca Wassmer, Laurent Rasquin, Sonja‐Verena Albers, Jennifer N. Andexer   +7 more
wiley   +1 more source

Synthesis of Six Natural Products Enabled by Selective Hydroxylation of Orcinaldehyde‐Like Substrates With an Enzyme Library

Angewandte Chemie, Volume 138, Issue 38, 14 September 2026.
Achieving selective (sp3)C–H hydroxylation can streamline the synthesis of complex organic molecules. Biocatalysis presents an opportunity to realize this transformation, however, identifying useful enzymes that enable synthetic strategies can be a challenge due to limitations in enzyme substrate scope.
Gonzalo J. Villegas Rodríguez, Evan O. Romero, Jonathan C. Perkins, Diego N. Rojas, Maximilian S. Hrigora, Alison R. H. Narayan   +5 more
wiley   +2 more sources