Results 101 to 110 of about 20,067 (277)

The Asymmetric Self‐Replicative Alkylation of N‐Arylaldimines Using Organolithium Reagents

Chemistry – A European Journal, EarlyView.
Here, we report a new asymmetric autoinductive reaction; the addition of nBuLi to N‐arylaldimines to form chiral lithium amides. The reaction proceeds with full conversion and complete transfer of chirality, representing the first example of an asymmetric autoinductive reaction with organolithium reagents.
Anka Hagelschuer, Paco Visser, Ben L. Feringa   +2 more
wiley   +1 more source

Strain Release of 1‐Azabicyclo[1.1.0]butanes as a Gateway to Highly Functionalized Azetidines: New Strategies and Structural Motifs

Chemistry – A European Journal, EarlyView.
Over the past decade, the interest in azetidines has continuously risen, by virtue of their highly appealing pharmaceutical properties. Monocyclic, spirocyclic, and bridged azetidines can be accessed by leveraging 1‐azabicyclo[1.1.0]butanes as precursors.
Yuri Gelato, Philipp Natho, Marco Colella, Renzo Luisi   +3 more
wiley   +1 more source

Synthesis of (±)-africanol

Journal of the Brazilian Chemical Society, 2000
Two diastereomers of africanol, compounds 1a and 1b, were obtained exclusively through a methodology which employed, as the key step, the nBuLi mediated intramolecular cyclization of the vinyl iodide 5.
Marques Francisco de A., Ferreira José T. B., Piers Edward   +2 more
doaj  

Separation of isobaric phosphorothioate oligonucleotides in capillary electrophoresis: study of the influence of cationic cyclodextrins on chemo and stereoselectivity

Frontiers in Analytical Science
Phosphorothioate (PS) oligonucleotides have drawn more and more attention lately due to their great therapeutic potential. The presence of one (or several) phosphorothioate moiety (ies) improves pharmacokinetic properties but at the same time creates an ...
Maryam K. Ghassemi, Vincent Hurlet, Jacques Crommen, Anne-Catherine Servais, Marianne Fillet   +4 more
doaj   +1 more source

Determination of the relative configuration of tropinone and granatanone aldols by using TBDMS ethers

Beilstein Journal of Organic Chemistry, 2012
The relative configurations of tert-butyldimethylsilyl (TBDMS) ethers of all four diastereomers of the aldols of tropinone (8-methyl-8-azabicyclo[3.2.1]octan-3-one), as well as of granatanone (9-methyl-9-azabicyclo[3.3.1]nonan-3-one), were determined ...
Ryszard Lazny, Aneta Nodzewska, Katarzyna Sidorowicz, Przemyslaw Kalicki   +3 more
doaj   +1 more source

Polarity on Demand: Nucleophilic, Electrophilic, and Ambiphilic Reactivity at a 9,10‐Dihydro‐9,10‐Disilaanthracene Platform

Chemistry – A European Journal, EarlyView.
A 9,10‐dihydro‐9,10‐disilaanthracene platform was efficiently synthesized and features intrinsically electrophilic Si sites. Upon stepwise reductive Si─H bond cleavage, these Si sites are converted into nucleophilic centers. This controlled polarity switching also enables ambiphilic reactivity within a homo‐heteroelement framework.
Moritz Schmidt, Alexander Virovets, Eugenia Peresypkina, Hans‐Wolfram Lerner, Matthias Wagner   +4 more
wiley   +1 more source

Elaboration of indirect method (test) for determination of enantiomeric purity of chiral PANAM (polyamide nucleic acids mimetics) monomers

Тонкие химические технологии, 2012
An indirect approach for the determination of enantiomeric purity of chiral α-(benzyl)-carboxyethyl- and γ-methyl-substituted monomers of polyamide nucleic acids mimics (PANAM) is described.
Yu. G. Kirillova, A. V. Ryakin, D. I. Prokhorov, M. A. Lyanov, O. V. Esipova, S. V. Eremin, E. E. Zvonkova   +6 more
doaj  

Assessing Benzene Dimer Interactions in Solution With a Molecular Balance

Chemistry – A European Journal, EarlyView.
The Gecko in the ToC was generated with Canva (31.03.2025 11:00 pm), the remaining graphics by the authors. ABSTRACT We present a combined experimental and computational study of a 1,4/1,6‐dibenzyl substituted cyclooctatetraene (COT)‐based molecular balance as a model to assess the benzene dimer interactions in solution.
Marvin H. J. Domanski, Michael Fuhrmann, Nils F. Hacket, Heike Hausmann, Peter R. Schreiner   +4 more
wiley   +1 more source

Catalytic Generation of Cationic Gold Carbene Complexes From 7‐Alkynylnorbornadienes and Their Intermolecular Cyclopropanation With Alkenes

Chemistry – A European Journal, EarlyView.
Efficient cationic gold(I)‐catalyzed intermolecular cyclopropanation of 7‐alkynylnorbornadiene derivatives has been developed. This methodology offers the synthesis of a new class of norbornene derivatives in high yield with excellent diastereoselectivity.
Kento Ishida, Kenta Toei, Fumiaki Tomi, Norio Sakai   +3 more
wiley   +1 more source

A study of neuroprotective effect stereospecificity of dipeptide mimetic of the Brain-derived neurotrophic factor GSB-106 on the model oxidative stress in the culture hippocampal cell line HT-22

Фармакокинетика и Фармакодинамика, 2017
In the present work, the neuroprotective effect stereospecificity of dimeric dipeptide mimetic of the 4th loop of BDNF-GSB-106 is studied. Activity of its diastereomers GT-106DL (hexamethylenediamide bis-monosuccinyl-D-seryl-L-lysine) and GT-106LD ...
I. O. Logvinov, A. V. Tarasiuk, P. I. Antipov, T. A. Antipova   +3 more
doaj