Results 81 to 90 of about 35,698 (262)
The synthesis of the 2,3-difluorobutan-1,4-diol diastereomers
Beilstein Journal of Organic Chemistry, 2017 The diastereoselective synthesis of fluorinated building blocks that contain chiral fluorine substituents is of interest. Here we describe optimisation efforts in the synthesis of anti-2,3-difluorobutane-1,4-diol, as well as the synthesis of the ...
Robert Szpera +4 more
doaj +1 more source
Chemistry – A European Journal, EarlyView.The synthesis of 2‐methyl propellane and its conversion to various 1,2‐ and 1,2,3‐di‐ and trisubstituted bicyclopentanes is reported. Abstract Bicyclo[1.1.1]pentanes (BCPs) have emerged as isosteric replacements for mono‐ and para‐substituted benzene rings in medicinal and materials applications, involving substitution at the BCP bridgehead (1,3 ...
Sean R. Verschaeve +4 more
wiley +1 more source
BioResources, 2015 Studying the stereochemistry of lignin as a natural chiral polymer may have scientific and technical importance regarding the behavior of lignin and delignification processes.
Mahnaz Oghbaie +2 more
doaj +1 more source
Chemistry and Biology of Streptogramin A Antibiotics [PDF]
, 2007 The streptogramin A antibiotics have proven to be highly active against Gram positive bacteria, particularly methicillin-resistant Staphylococcus aureus. Members of this group of compounds are characterized by a 23-membered macrocycles containing polyene,
Ahmed, Fahim, Donaldson, William
core +1 more source
Scope and limitations of aliphatic Friedel-Crafts alkylations. Lewis acid catalyzed addition reactions of alkyl chlorides to carbon-carbon double bonds [PDF]
, 1983 Lewis acid catalyzed addition reactions of alkyl halides 1 with unsaturated hydrocarbons 2 have been studied. 1:l addition products 3 are formed if the addends 1 dissociate faster than the corresponding products 3; otherwise, polymerization of 2 takes ...
Mayr, Herbert, Striepe, Wilhelm
core +1 more source
Pharmaceuticals Made with Hydrogen: A Sustainable and Efficient Approach Using Flow Synthesis
Chemistry – A European Journal, EarlyView.We demonstrate a sustainable strategy for pharmaceutical manufacturing by combining hydrogen, heterogeneous catalysis, and continuous flow synthesis. The development of novel catalysts and their application in a multi‐step synthesis of donepezil enabled a highly productive process with no intermediate purification.
Shū Kobayashi, Haruro Ishitani
wiley +1 more source
Analysis of L- and D-Amino Acids Using UPLC
Bio-Protocol, 2014 With the exception of glycine, α-amino acids are optically active, and two optical isomers (L- and D-) of each amino acid can be formed. Recent developments of analytical techniques have revealed that several free D-amino acids such as D-aspartate, D ...
Yuta Mutaguchi, Toshihisa Ohshima
doaj +1 more source
Big Data meets Quantum Chemistry Approximations: The $\Delta$-Machine Learning Approach
, 2015 Chemically accurate and comprehensive studies of the virtual space of all possible molecules are severely limited by the computational cost of quantum chemistry.
Dral, Pavlo O. +3 more
core
Synthesis, characterization and antifungal assessment of optically active bis-organotin compounds derived from (S)-BINOL diesters [PDF]
, 2019 Background: Organotin(IV) derivatives have appeared recently as potential biologically active metallopharmaceuticals exhibiting a variety of therapeutic activities.
Costantino, Andrea Rosana +6 more
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Chemistry – A European Journal, EarlyView.Composite materials based on metal nanoparticles supported on a naturally occurring nanotubular clay, halloysite (HAL), led to the diastereoselective hydrogenation of tetra‐substituted alkenes under relatively smooth conditions, mainly oxazolidinone‐based heterocycles.
Rosa Pich +9 more
wiley +1 more source