Results 81 to 90 of about 19,944 (197)

Evaluation of chlorofusin, its seven chromophore diastereomers, and key analogues

, 2009
Chlorofusin, its seven chromophore diastereomers, and key analogues were comparatively examined for inhibition of MDM2–p53 binding revealing that the chromophore, but not simple replacements, contributes significantly to the natural products properties ...
Lee, Sang Yeul, Mark Searcey, Clark, Ryan C., Ryan C. Clark, Sang Yeul Lee, Dale L. Boger, Hwang, Inkyu, Searcey, Mark, Boger, Dale L., Inkyu Hwang   +9 more
core   +1 more source

Elaboration of indirect method (test) for determination of enantiomeric purity of chiral PANAM (polyamide nucleic acids mimetics) monomers

Тонкие химические технологии, 2012
An indirect approach for the determination of enantiomeric purity of chiral α-(benzyl)-carboxyethyl- and γ-methyl-substituted monomers of polyamide nucleic acids mimics (PANAM) is described.
Yu. G. Kirillova, A. V. Ryakin, D. I. Prokhorov, M. A. Lyanov, O. V. Esipova, S. V. Eremin, E. E. Zvonkova   +6 more
doaj  

Determining the Extent of Biodegradation of Fuels Using the Diastereomers of Acyclic Isoprenoids

, 2016
Improved testing and remediation procedures for sites contaminated with petroleum hydrocarbons are a priority in remote cold regions such as Antarctica, where costs are higher and remediation times are longer. Isoprenoid/n-alkane ratios are commonly used
Susan H. Ferguson (2498431), Simon C. George (2498428), Cameron P. McIntyre (2359690), Ian Snape (1687159), Paul McA. Harvey (2056945), Anna M. Wressnig (2498434), Herbert Volk (2498437)   +6 more
core   +1 more source

A study of neuroprotective effect stereospecificity of dipeptide mimetic of the Brain-derived neurotrophic factor GSB-106 on the model oxidative stress in the culture hippocampal cell line HT-22

Фармакокинетика и Фармакодинамика, 2017
In the present work, the neuroprotective effect stereospecificity of dimeric dipeptide mimetic of the 4th loop of BDNF-GSB-106 is studied. Activity of its diastereomers GT-106DL (hexamethylenediamide bis-monosuccinyl-D-seryl-L-lysine) and GT-106LD ...
I. O. Logvinov, A. V. Tarasiuk, P. I. Antipov, T. A. Antipova   +3 more
doaj  

Synthesis of a new type of antitumour agent panaxytriol: synthesis of its four diastereomers

, 1999
Synthesis of four diastereomers of panaxytriol has been described. The basic objective is to create two acetylenic precursors followed by cuprous chloride mediated C-C coupling ...
Sylesh Kumar, V., Venkateswara Rao, B, Gurjar, Mukund K.   +2 more
core   +1 more source

Unified Total Synthesis of Pteriatoxins and Their Diastereomers

, 2016
A unified total synthesis is reported to access all of the possible diastereomers of pteriatoxins A−C, with the use of an intramolecular Diels−Alder reaction as the key step to form the carbo-macrocyclic core structure. The C34/C35-diol protecting groups
Scott S. Harried (2025583), Fumiyoshi Matsuura (2534815), Junliang Hao (1947352), René Peters (675293), Masahiro Anada (2270140), Yoshito Kishi (505169)   +5 more
core   +1 more source

The use of 31P NMR and principal components analysis to determine sameness or differences between diastereomeric composition of phosphorothioate oligonucleotides

Talanta Open
Synthetic oligonucleotides often contain chemically modified backbones to prevent degradation and improve bioactivity. Phosphorothioate (PS) linkage in place of phosphodiester is the most used one.
Luca Gherardi, Francesca Viti, Salvatore Demartis, Marie McNulty, Giovanni Monteleone, Lorenzo Di Bari   +5 more
doaj   +1 more source

Toward the synthesis of spirastrellolide A: construction of two C1-C25 diastereomers containing the BC-spiroacetal.

, 2005
[reaction: see text] Stereo-controlled syntheses of two possible C1-C25 diastereomers of spirastrellolide A containing the cis-disubstituted tetrahydropyran and [6,6]-spiroacetal are reported, exploiting boron-mediated asymmetric aldol and allylation ...
Anderson, EA, Anderson, Edward, Paterson, I, Loiseleur, O, Dalby, SM   +4 more
core   +1 more source

Separation of phosphinic pseudopeptide diastereomers by CZE and RP-HPLC

, 2003
Capillary zone electrophoresis (CZE) and reverse phase high-performance liquid chromatography (RP-HPLC) were used for separation of diastereomers of phosphinic pseudopeptides.
Koval, Dušan
core  

Multi-color luminescent crystals derived from dynamic diastereomers of a perylene-substituted binaphthol derivative [PDF]

Herein, we demonstrate a novel strategy for obtaining multi-color luminescent crystals. A perylene-substituted (S)-binaphthol derivative was designed, exhibiting dynamic conversion of diastereomers in solution.
Yano, Riko, Ito, Suguru, 80724418, 0000-0002-0268-013X   +3 more
core