Sustainable Pd‐Catalyzed Aminations “on Dirty Water”
Angewandte Chemie, EarlyView.Aminations, done safely yet neat, and therefore, quickly, using low levels of Pd, in “dirty water” that must contain 30% KOH; not NaOH, and not at 5%,10%, 20%, 40%, or 50% KOH. Moreover, no base sensitivity of functional groups! Very cool. Thank you, Nature.
Erfan Oftadeh +4 more
wiley +2 more sources
Short columns with molecularly imprinted monolithic stationary phases for rapid separation of diastereomers and enantiomers [PDF]
, 2004 Three molecularly imprinted monolithic columns with different length but almost identical column volume had been prepared. It was observed that the separation factors of diastereomers and enantiomers were almost unaffected by column length.
Zou, HF +4 more
core +1 more source
Effects of 3,N,N′-trimethyl-2-phenyl-1,4-piperazine diastereomers on monoamine uptake and monoamine oxidase in rat brain [PDF]
, 1992 The diastereomers of 3,N,N′-trimethyl-2-phenyl-1,4-piperazine dihydrochloride (TPP) were tested for their effects on NA, DA and 5-HT uptake in synaptosomes prepared from hypothalamus, corpus striatum, and frontal cortex, respectively.
Tytgat, D. +3 more
core +1 more source
Synthesis of the Eight Enantiomerically Pure Diastereomers of the 12-F2-Isoprostanes [PDF]
, 2016 Syntheses of the eight enantiomerically pure diastereomers of the 12-F2-isoprostanes (4−11) are described. The key steps included rhodium-mediated intramolecular cyclopropanation and enzymatic resolution of the racemic diol ...
Ming Xu (151206) +2 more
core +5 more sources
Delta/Lambda Chirality: From Enantiomers to Diastereomers in Heterometallic Complexes with Chelating Ligands. [PDF]
Inorg ChemThe Δ/Λ chirality observed in octahedral molecules with chelating ligands represents the major group of “chiral-at-metal” complexes. Upon shifting from mononuclear to polynuclear systems with multiple (≥2) chiral centers, not only enantiomers but also ...
Zhang Y +6 more
europepmc +3 more sources
Total Synthesis of Both Spiroketal Diastereomers of the Reported Structure of Cephalosporolide H [PDF]
, 2013 A total synthesis of both spiroketal diastereomers of the reported structure of cephalosporolide H is accomplished in 12 steps and 9% overall yield. The key steps involve Keck's allylation, cross metathesis (to get the desired beta,gamma-unsaturated ...
FERNANDES, RA, HALLE, MB
core +1 more source
Unified Synthesis of Unconventional α‐Polyhalogenated Amines Through Hydroaminoalkylation
Angewandte Chemie International Edition, EarlyView.A unified, redox‐neutral method that transforms alkenes and alkynes into α‐polyhalomethyl amines using stable hemiaminal reagents is reported. This approach enables access to CF3, CF2H, CF2Cl, and CFClH motifs, expanding halogenated amine space with broad substrate scope, functional group tolerance, and applicability to late‐stage modification of drug ...
Angela K. Hofmeister +9 more
wiley +1 more source
Angewandte Chemie International Edition, EarlyView.The first catalytic asymmetric formal [3+2] cycloaddition of allylsilanes delivers cis‐2,5‐disubstituted tetrahydrofuran‐3‐ones that serve as versatile intermediates for the synthesis of diverse bioactive scaffolds. ABSTRACT A formal [3+2] cycloaddition via cyclization/1,2‐hydride shift initiated by nucleophilic attack of allylsilanes has been ...
Hosung Lee +5 more
wiley +1 more source
Data in Brief, 2019 This article presents new data on the properties of the diastereomers of a mono-substituted phosphoryl guanidine trideoxyribonucleotides d(TpCp*A) [1,2].
Alexander A. Lomzov +6 more
doaj +1 more source
The First Synthesis and Characterization of Both Diastereomers of a Di[2.2]paracyclophane: 4,4‘-Bis(1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane) [PDF]
, 2016 The synthesis and characterization of both diastereomers of a system comprised of two [2.2]paracyclophane units linked through a single 4,4‘ bond are described.
A. J. Roche (3030345) +3 more
core +1 more source