Results 71 to 80 of about 14,574 (240)

A Practical Method for the Stereochemical Analysis of Acyclic Terpenoid Carbonyl Compounds

CHIMIA, 1989
The stereoisomeric composition of acyclic terpene aldehydes and ketones can be assayed by derivatization with L(+)-diisopropyl tartrate and separation of the ensuing acetal diastereomers by gas chromatography.
Andreas Knierzinger, Willy Walther, Beat Weber, Thomas Netscher   +3 more
doaj   +1 more source

Evolutionary, Functional and Mechanistic Characterisation of Microbial Terpene Synthase‐Like Genes From Springtails

Angewandte Chemie International Edition, EarlyView.
A genome analysis revealed the presence of many bacterial‐type terpene synthases in springtails. Four enzymes from Sinella curviseta were functionally characterised, resulting in the isolation of several compounds including sinellene ether, the first diterpene ether identified from a terpene synthase that represents a novel skeleton.
Min Wang, Clement Schneider, Zarley Rebholz, Stefan Schulz, Kathy Darragh, Jeroen S. Dickschat   +5 more
wiley   +1 more source

Synthesis of (±)-africanol

Journal of the Brazilian Chemical Society, 2000
Two diastereomers of africanol, compounds 1a and 1b, were obtained exclusively through a methodology which employed, as the key step, the nBuLi mediated intramolecular cyclization of the vinyl iodide 5.
Marques Francisco de A., Ferreira José T. B., Piers Edward   +2 more
doaj  

Separation of isobaric phosphorothioate oligonucleotides in capillary electrophoresis: study of the influence of cationic cyclodextrins on chemo and stereoselectivity

Frontiers in Analytical Science
Phosphorothioate (PS) oligonucleotides have drawn more and more attention lately due to their great therapeutic potential. The presence of one (or several) phosphorothioate moiety (ies) improves pharmacokinetic properties but at the same time creates an ...
Maryam K. Ghassemi, Vincent Hurlet, Jacques Crommen, Anne-Catherine Servais, Marianne Fillet   +4 more
doaj   +1 more source

Determination of the relative configuration of tropinone and granatanone aldols by using TBDMS ethers

Beilstein Journal of Organic Chemistry, 2012
The relative configurations of tert-butyldimethylsilyl (TBDMS) ethers of all four diastereomers of the aldols of tropinone (8-methyl-8-azabicyclo[3.2.1]octan-3-one), as well as of granatanone (9-methyl-9-azabicyclo[3.3.1]nonan-3-one), were determined ...
Ryszard Lazny, Aneta Nodzewska, Katarzyna Sidorowicz, Przemyslaw Kalicki   +3 more
doaj   +1 more source

Elaboration of indirect method (test) for determination of enantiomeric purity of chiral PANAM (polyamide nucleic acids mimetics) monomers

Тонкие химические технологии, 2012
An indirect approach for the determination of enantiomeric purity of chiral α-(benzyl)-carboxyethyl- and γ-methyl-substituted monomers of polyamide nucleic acids mimics (PANAM) is described.
Yu. G. Kirillova, A. V. Ryakin, D. I. Prokhorov, M. A. Lyanov, O. V. Esipova, S. V. Eremin, E. E. Zvonkova   +6 more
doaj  

A study of neuroprotective effect stereospecificity of dipeptide mimetic of the Brain-derived neurotrophic factor GSB-106 on the model oxidative stress in the culture hippocampal cell line HT-22

Фармакокинетика и Фармакодинамика, 2017
In the present work, the neuroprotective effect stereospecificity of dimeric dipeptide mimetic of the 4th loop of BDNF-GSB-106 is studied. Activity of its diastereomers GT-106DL (hexamethylenediamide bis-monosuccinyl-D-seryl-L-lysine) and GT-106LD ...
I. O. Logvinov, A. V. Tarasiuk, P. I. Antipov, T. A. Antipova   +3 more
doaj  

The use of 31P NMR and principal components analysis to determine sameness or differences between diastereomeric composition of phosphorothioate oligonucleotides

Talanta Open
Synthetic oligonucleotides often contain chemically modified backbones to prevent degradation and improve bioactivity. Phosphorothioate (PS) linkage in place of phosphodiester is the most used one.
Luca Gherardi, Francesca Viti, Salvatore Demartis, Marie McNulty, Giovanni Monteleone, Lorenzo Di Bari   +5 more
doaj   +1 more source

Chemotherapeutic molecular switch behavior of aryl-substituted tetracarboxylic dianhydrides

Pakistan Journal of Pharmaceutical Sciences
In this study, we synthesized aryl-substituted tetracarboxylic acid dianhydride (TCDA) diastereomers having potential for chemoselective DNA alkylation. The TCDAs were obtained through a radical-initiated addition chain reaction.
Hamdullah Khadim Sheikh, Tanzila Arshad, Haroon Khan, Uzma Habib, Jamelah Saleh Al-Otaibi, Tan Ching Siang, Faiza Iqbal, Umbreen Farrukh BioLab, Universidad de La Laguna, Spain   +9 more
doaj   +1 more source

Titanium‐Catalyzed Diastereoselective Keto‐ and Iminonitrile Cyclizations

Chemistry – A European Journal, EarlyView.
The titanium(III)‐catalyzed diastereoselective cyclization of readily‐available substituted ketonitriles gives cyclopentanones in good yield and stereoselectivity. Subsequent 1,2‐addition allows the preparation of cyclopentyls with three consecutive stereocenters.
Christoph Kern, Ritu Singh, Michael A. Unkrig‐Bau, Lukas Jakob, Jan Streuff   +4 more
wiley   +1 more source