Results 151 to 160 of about 20,067 (277)

Prostate Cancer Development, Progression, and Therapy

MedComm – Oncology, Volume 5, Issue 3, September 2026.
This review provides an integrated overview of prostate cancer development, progression, and therapy, spanning historical milestones, molecular mechanisms, advanced research models, and emerging therapeutic strategies. It highlights recent advances in precision diagnosis, lineage plasticity, therapy resistance, and next‐generation treatments for ...
Xin Jin, Zicheng Xiao, Zexian Ding, Wei Li, Ruijiang Zeng, Yujun Shuai, Weimin Ci, Dan Xia, Xu Zhang, Haojie Huang   +9 more
wiley   +1 more source

Metasurface analogues of molecular diastereomers from hierarchical multiscale chiral interactions with biomolecules. [PDF]

Nat Commun
Koyroytsaltis-McQuire DJP, Chaubey SK, Kumar R, Lalaguna PL, Javorfi T, Siligardi G, Karimullah A, Lapthorn AJ, Tanaka YY, Hashiyada S, Gadegaard N, Kadodwala M.   +11 more
europepmc   +1 more source

Characterization of Grape Cane Stilbenoids and Their Photo‐Degradation Products by HPLC‐DAD Coupled With Trapped Ion Mobility Spectrometry and High‐Resolution Tandem Mass Spectrometry

Rapid Communications in Mass Spectrometry, Volume 40, Issue 15, 15 August 2026.
ABSTRACT Rationale Bioactive (E)‐stilbenoids in vine extracts are prone to light‐induced transformation into the respective (Z)‐isomers and further degradation products, often resulting in a loss of bioactivity. We sought to study stilbenoid degradation beyond that of the well‐researched resveratrol due to the high diversity of stilbenoids in nature ...
Paul Besrukow, Friederike A. Schnitker, Ralf Schweiggert, Christof B. Steingass   +3 more
wiley   +1 more source

Enantioselective Synthesis of a New Class of Stable and Functionalized Cyclopentadienes via CuH‐Catalysis

Angewandte Chemie, Volume 138, Issue 32, 3 August 2026.
Cyclopentadienes (CpHs) are fundamental building blocks with widespread applications in chemistry. However, their inherent acidity and isomeric instability have long limited access to chiral variants in an asymmetric fashion. Here, we introduce a CuH‐catalyzed asymmetric transformation that provides an unprecedented entry into a new class of ...
Piero Soppelsa, Riccardo Bellin, Besma Boulila, Francesco Vaghi, Manuel Orlandi   +4 more
wiley   +2 more sources

Actinomycin Derivatives: Structural Diversification and Biological Activities

ChemMedChem, Volume 21, Issue 15, 14 August 2026.
Actinomycins are chromopeptide antibiotics exhibiting remarkable structural diversity and broad bioactivity. This review traces their development from naturally occurring D‐, X‐, A‐, G‐, Y‐, and Z‐type analogs to precursor‐directed, synthetic, and semisynthetic derivatives.
Özge Can, Erdal Bedir
wiley   +1 more source

Semisynthesis of Mycothiazole Analogs having Distinct Bioactivity. [PDF]

ACS Med Chem Lett
Clarke JG, Dutta N, Nickel MS, Wang Z, Kim J, Media J, Coppage DA, McCauley EP, Gerke JA, Anderson MO, Higuchi-Sanabria R, Valeriote FA, Crews P, Johnson TA.   +13 more
europepmc   +1 more source

Fragmentation of Vancoresmycin Reveals a Strong Dependence on Global Molecular Architecture for Antibacterial Activity

ChemMedChem, Volume 21, Issue 15, 14 August 2026.
Fragmentation of the natural product vancoresmycin reveals an essential role of global architecture for biological potency. Vancoresmycin is a structurally complex tetramic‐acid‐containing natural product with potent activity against Gram‐positive bacteria, yet its structure–activity relationships remain poorly defined.
Max Schönenbroicher, Florian Heppner, Maximilian Seul, Simon Morgenschweis, Aia Ali Abdelrahman, Eva Fahr, Niklas Holstein, Anna Müller, Dirk Menche   +8 more
wiley   +1 more source

Fatty Acid and Amino Acid Derivatives in Organocatalyzed Michael Additions. [PDF]

Molecules
Flis A, Brodnik H, Petek N, Požgan F, Svete J, Štefane B, Ciber L, Grošelj U.   +7 more
europepmc   +1 more source

The use of multiple liquid chromatography methods augmented by phosphorus-31 nuclear magnetic resonance to characterize the diastereomer composition in synthetic oligonucleotides. [PDF]

J Chromatogr A
Ali M, Manghrani A, Szramowski M, Abdel-Megied AM, Liang L, Aberg NF, Yang K, Chen K, Wang Y, Zhang D, Fletcher S, Brinson RG, Jones JW.   +12 more
europepmc   +1 more source

Multichiral Half-Sandwich Ru(II) and Os(II) Anticancer Complexes Containing a Glutathione Synthesis Inhibitor. [PDF]

Organometallics
Kumari P, Bridgewater HE, Anisi S, Whitehouse CM, Millett AJ, Chellan P, Romero-Canelón I, Clarkson GJ, Schünemann V, Wolny JA, Sadler PJ.   +10 more
europepmc   +1 more source