Results 11 to 20 of about 11,974 (182)

Kir1.1 and SUR1 are not implicated as subunits of an adenosine triphosphate-sensitive potassium channel involved in diazoxide cardioprotectionCentral MessagePerspective

JTCVS Open, 2023
Objective: The adenosine triphosphate-sensitive potassium channel opener diazoxide mimics ischemic preconditioning and is cardioprotective. Clarification of diazoxide's site and mechanism of action could lead to targeted pharmacologic therapies for ...
Jie Wang, MD, Kyriakos Papanicolaou, PhD, Robert Tryon, PhD, Janelle Sangalang, BA, Ben Salazar, BS, Alejandro Suarez-Pierre, MD, Jie Dong, MD, Anson Lee, BS, BA, Emily Larson, BS, Sari Holmes, PhD, Brian O’Rourke, PhD, Colin Nichols, PhD, Jennifer Lawton, MD   +12 more
doaj   +1 more source

Evaluation of spasmolytic effects of naringenin on ileum contraction and intestinal charcoal meal transit: Involvement of ATP-sensitive K+ channels [PDF]

Journal of HerbMed Pharmacology, 2022
Introduction: Naringenin is a flavonoid constituent of many herbal plants, including citreous fruits. Biological studies have suggested various therapeutic effects for naringenin, including protective effects on gastrointestinal (GI) motility.
Hassan Sadraei, Maedeh Ghasemi, Salman Saranji   +2 more
doaj   +1 more source

ATP—Sensitive Potassium Channel Opener Diazoxide Reduces Myocardial Stunning in a Porcine Regional With Subsequent Global Ischemia Model

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022
Background ATP‐sensitive potassium channels are inhibited by ATP and open during metabolic stress, providing endogenous myocardial protection. Pharmacologic opening of ATP potassium channels with diazoxide preserves myocardial function following ...
Ana K. Velez, Eric Etchill, Katherine Giuliano, Sean Kearney, Melissa Jones, Jie Wang, Brian Cho, Mary Beth Brady, Jeffrey Dodd‐o, Joseph M. Meyer, Jennifer S. Lawton   +10 more
doaj   +1 more source

Pulmonary hypertension associated with diazoxide: the SUR1 paradox

ERJ Open Research, 2023
The ATP-sensitive potassium channels and their regulatory subunits, sulfonylurea receptor 1 (SUR1/Kir6.2) and SUR2/Kir6.1, contribute to the pathophysiology of pulmonary hypertension (PH).
David Montani, Fabrice Antigny, Etienne-Marie Jutant, Marie-Camille Chaumais, Hélène Le Ribeuz, Julien Grynblat, Charles Khouri, Marc Humbert   +7 more
doaj   +1 more source

Ubiquinol-cytochrome c reductase core protein 1 may be involved in delayed cardioprotection from preconditioning induced by diazoxide. [PDF]

PLoS ONE, 2017
This study aimed to use long-term diazoxide treatment to establish a loss-of-cardioprotection model and then perform proteomics analysis to explore which proteins of mitochondrial inner membrane (MIM) are potentially involved in delayed cardioprotection.
Zonghong Long, Guangyou Duan, Hong Li, Tingting Yi, Xiaoxiao Wu, Feng Chen, Zhuoxi Wu, Yuqi Gao   +7 more
doaj   +1 more source

A Rare Side Effect of Diazoxide Therapy: Pulmonary Hipertension

Journal of Behçet Uz Children's Hospital, 2020
We present a newborn diagnosed with Beckwith-Wiedemann syndrome and hypoglycemia, and developed pulmonary hypertension due to initiated diazoxide treatment because of these indications.
Alper Hazım Gürsu, Emine Azak, Eda Mengen, Sevim Ünal, Ibrahim Ilker Cetin   +4 more
doaj   +1 more source

Diazoxide-associated pulmonary hypertension in a patient with noncompaction cardiomyopathy

Pulmonary Circulation, 2021
Development of pulmonary hypertension after initiation of diazoxide for the treatment of neonatal hyperinsulinemic hypoglycemia is a rare, but previously described association.
Rachel T. Sullivan, Kathryn A. Tillman, Steven J. Kindel, Stephanie S. Handler   +3 more
doaj   +1 more source

Metabolomics analysis in rat hearts with ischemia/reperfusion injury after diazoxide postconditioning

Frontiers in Molecular Biosciences, 2023
Background: Diazoxide is a selective mitochondrial-sensitive potassium channel opening agent that has a definite effect on reducing myocardial ischemia/reperfusion injury (MIRI).
Cen Xiang, Cen Xiang, Shoujia Yu, Qiyang Ren, Boyi Jiang, Jing Li, Donghang Zhang, Yiyong Wei   +7 more
doaj   +1 more source

Diazoxide use for neonatal hyperinsulinaemic hypoglycaemia in a low-resource setting: A Case Report

Annals of Health Research, 2020
The management of neonatal hyperinsulinaemic hypoglycaemia remains a major challenge in hospitalized newborns globally. Diazoxide is one of the recommended therapeutic options.
Adekoya AO, Adekanye TE, Abolurin OO, Adebawojo OO, Ajayi FG, Ajibola ED   +5 more
doaj   +1 more source

Comparative Effect of Three Different Exercise Intensities in Combination with Diazoxide on Contraction Capacity and Oxidative Stress of Skeletal Muscle in Obese Rats

Biology, 2022
Obesity is a chronic disease that impairs skeletal muscle function, affects the ability to contract, and promotes the development of fatigue. For this reason, the study of treatments that seek to reduce the harmful effects of obesity on muscle tissue has
Mariana Gómez-Barroso, Manuel A. Vargas-Vargas, Donovan J. Peña-Montes, Christian Cortés-Rojo, Alfredo Saavedra-Molina, Elizabeth Sánchez-Duarte, Alain R. Rodríguez-Orozco, Rocío Montoya-Pérez   +7 more
doaj   +1 more source