Results 11 to 20 of about 14,174 (227)

Diazoxide-Induced Hypertrichosis in a Neonate With Transient Hyperinsulinism

Clinical Medicine Insights: Case Reports, 2023
Diazoxide is one of the FDA-approved pharmacologic treatments for hyperinsulinemic hypoglycemia, however, its adverse effects in infants are not well described. We reported a 37-week-old boy with the diagnosis of hypoglycemia.
Seyyed Javad Boskabadi, Sima Ramezaninejad, Masoumeh Sohrab, Roya Farhadi   +3 more
doaj   +1 more source

Diazoxide Post-conditioning Activates the HIF-1/HRE Pathway to Induce Myocardial Protection in Hypoxic/Reoxygenated Cardiomyocytes

Frontiers in Cardiovascular Medicine, 2021
Background: Previous studies have shown that diazoxide can protect against myocardial ischemia-reperfusion injury (MIRI). The intranuclear hypoxia-inducible factor-1 (HIF-1)/hypoxia-response element (HRE) pathway has been shown to withstand cellular ...
Xi-Yuan Chen, Xi-Yuan Chen, Jia-Qi Wang, Si-Jing Cheng, Yan Wang, Meng-Yuan Deng, Tian Yu, Hai-Ying Wang, Wen-Jing Zhou, Wen-Jing Zhou   +9 more
doaj   +1 more source

Kir1.1 and SUR1 are not implicated as subunits of an adenosine triphosphate-sensitive potassium channel involved in diazoxide cardioprotectionCentral MessagePerspective

JTCVS Open, 2023
Objective: The adenosine triphosphate-sensitive potassium channel opener diazoxide mimics ischemic preconditioning and is cardioprotective. Clarification of diazoxide's site and mechanism of action could lead to targeted pharmacologic therapies for ...
Jie Wang, MD, Kyriakos Papanicolaou, PhD, Robert Tryon, PhD, Janelle Sangalang, BA, Ben Salazar, BS, Alejandro Suarez-Pierre, MD, Jie Dong, MD, Anson Lee, BS, BA, Emily Larson, BS, Sari Holmes, PhD, Brian O’Rourke, PhD, Colin Nichols, PhD, Jennifer Lawton, MD   +12 more
doaj   +1 more source

Evaluation of spasmolytic effects of naringenin on ileum contraction and intestinal charcoal meal transit: Involvement of ATP-sensitive K+ channels [PDF]

Journal of HerbMed Pharmacology, 2022
Introduction: Naringenin is a flavonoid constituent of many herbal plants, including citreous fruits. Biological studies have suggested various therapeutic effects for naringenin, including protective effects on gastrointestinal (GI) motility.
Hassan Sadraei, Maedeh Ghasemi, Salman Saranji   +2 more
doaj   +1 more source

ATP—Sensitive Potassium Channel Opener Diazoxide Reduces Myocardial Stunning in a Porcine Regional With Subsequent Global Ischemia Model

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022
Background ATP‐sensitive potassium channels are inhibited by ATP and open during metabolic stress, providing endogenous myocardial protection. Pharmacologic opening of ATP potassium channels with diazoxide preserves myocardial function following ...
Ana K. Velez, Eric Etchill, Katherine Giuliano, Sean Kearney, Melissa Jones, Jie Wang, Brian Cho, Mary Beth Brady, Jeffrey Dodd‐o, Joseph M. Meyer, Jennifer S. Lawton   +10 more
doaj   +1 more source

Pulmonary hypertension associated with diazoxide: the SUR1 paradox

ERJ Open Research, 2023
The ATP-sensitive potassium channels and their regulatory subunits, sulfonylurea receptor 1 (SUR1/Kir6.2) and SUR2/Kir6.1, contribute to the pathophysiology of pulmonary hypertension (PH).
David Montani, Fabrice Antigny, Etienne-Marie Jutant, Marie-Camille Chaumais, Hélène Le Ribeuz, Julien Grynblat, Charles Khouri, Marc Humbert   +7 more
doaj   +1 more source

A Rare Side Effect of Diazoxide Therapy: Pulmonary Hipertension

Journal of Behçet Uz Children's Hospital, 2020
We present a newborn diagnosed with Beckwith-Wiedemann syndrome and hypoglycemia, and developed pulmonary hypertension due to initiated diazoxide treatment because of these indications.
Alper Hazım Gürsu, Emine Azak, Eda Mengen, Sevim Ünal, Ibrahim Ilker Cetin   +4 more
doaj   +1 more source

Diazoxide-associated pulmonary hypertension in a patient with noncompaction cardiomyopathy

Pulmonary Circulation, 2021
Development of pulmonary hypertension after initiation of diazoxide for the treatment of neonatal hyperinsulinemic hypoglycemia is a rare, but previously described association.
Rachel T. Sullivan, Kathryn A. Tillman, Steven J. Kindel, Stephanie S. Handler   +3 more
doaj   +1 more source

Metabolomics analysis in rat hearts with ischemia/reperfusion injury after diazoxide postconditioning

Frontiers in Molecular Biosciences, 2023
Background: Diazoxide is a selective mitochondrial-sensitive potassium channel opening agent that has a definite effect on reducing myocardial ischemia/reperfusion injury (MIRI).
Cen Xiang, Cen Xiang, Shoujia Yu, Qiyang Ren, Boyi Jiang, Jing Li, Donghang Zhang, Yiyong Wei   +7 more
doaj   +1 more source

A Deep Clinical and Biochemical Characterization of a Patient With Combined Malonic and Methylmalonic Aciduria (CMAMMA). [PDF]

JIMD Rep
ABSTRACT Combined malonic and methylmalonic aciduria (CMAMMA) is an inborn error of metabolism caused by a deficiency in mitochondrial malonyl‐CoA synthetase, the enzyme responsible for activating malonic acid (MA) to malonyl‐CoA, a precursor of lipoic acid.
Gragnaniello V, Galderisi A, Tucci S, Doimo M, Caterino M, Loro C, Cazzorla C, Ruoppolo M, Salviati L, Burlina AB.   +9 more
europepmc   +2 more sources