Results 11 to 20 of about 13,368 (258)
Managing Hypoglycaemia in Patients With Insulinoma-A Tertiary Centre Experience and Review of the Literature. [PDF]
Clin Endocrinol (Oxf)ABSTRACT The management of hypoglycaemia is pivotal in the care of patients with insulinoma. Blood glucose monitoring and regulation needs careful attention pre‐ and peri‐operatively for patients undergoing surgical resection and as part of the long‐term management for patients with inoperable or metastatic disease.
Howarth S, Ho TW, Wimbury J, Casey R.
europepmc +2 more sources
Ubiquinol-cytochrome c reductase core protein 1 may be involved in delayed cardioprotection from preconditioning induced by diazoxide. [PDF]
PLoS ONE, 2017 This study aimed to use long-term diazoxide treatment to establish a loss-of-cardioprotection model and then perform proteomics analysis to explore which proteins of mitochondrial inner membrane (MIM) are potentially involved in delayed cardioprotection.
Zonghong Long +7 more
doaj +1 more source
Pulmonary hypertension associated with diazoxide: the SUR1 paradox
ERJ Open Research, 2023 The ATP-sensitive potassium channels and their regulatory subunits, sulfonylurea receptor 1 (SUR1/Kir6.2) and SUR2/Kir6.1, contribute to the pathophysiology of pulmonary hypertension (PH).
David Montani +7 more
doaj +1 more source
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022 Background ATP‐sensitive potassium channels are inhibited by ATP and open during metabolic stress, providing endogenous myocardial protection. Pharmacologic opening of ATP potassium channels with diazoxide preserves myocardial function following ...
Ana K. Velez +10 more
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Biology, 2022 Obesity is a chronic disease that impairs skeletal muscle function, affects the ability to contract, and promotes the development of fatigue. For this reason, the study of treatments that seek to reduce the harmful effects of obesity on muscle tissue has
Mariana Gómez-Barroso +7 more
doaj +1 more source
Structure of benzothiadiazine at zwitterionic phospholipid cell membranes [PDF]
, 2021 The use of drugs derived from benzothiadiazine, which is a bicyclic heterocyclic benzene derivative, has become a widespread treatment for diseases such as hypertension (treated with diuretics such as bendroflumethiazide or chlorothiazide), low blood sugar (treated with non-diuretic diazoxide) or the human immunodeficiency virus, among others.
arxiv +1 more source
A Rare Side Effect of Diazoxide Therapy: Pulmonary Hipertension
Journal of Behçet Uz Children's Hospital, 2020 We present a newborn diagnosed with Beckwith-Wiedemann syndrome and hypoglycemia, and developed pulmonary hypertension due to initiated diazoxide treatment because of these indications.
Alper Hazım Gürsu +4 more
doaj +1 more source
Diazoxide for Neonatal Hyperinsulinemic Hypoglycemia and Pulmonary Hypertension
Children, 2022 Hypoglycemia in neonates is associated with long-term neurodevelopmental effects. Hyperinsulinemic hypoglycemia (HH) is the most common cause of persistent hypoglycemia in neonatal intensive care units.
Shoshana Newman-Lindsay +2 more
doaj +1 more source
Diazoxide-associated pulmonary hypertension in a patient with noncompaction cardiomyopathy
Pulmonary Circulation, 2021 Development of pulmonary hypertension after initiation of diazoxide for the treatment of neonatal hyperinsulinemic hypoglycemia is a rare, but previously described association.
Rachel T. Sullivan +3 more
doaj +1 more source
Frontiers in Molecular Biosciences, 2023 Background: Diazoxide is a selective mitochondrial-sensitive potassium channel opening agent that has a definite effect on reducing myocardial ischemia/reperfusion injury (MIRI).
Cen Xiang +7 more
doaj +1 more source