Results 41 to 50 of about 11,974 (182)
Partial diazoxide responsiveness in a neonate with hyperinsulinism due to homozygous ABCC8 mutation
Endocrinology, Diabetes & Metabolism Case Reports, 2019 We report a case of partial diazoxide responsiveness in a child with severe congenital hyperinsulinaemic hypoglycaemia (CHI) due to a homozygous ABCC8 mutation.
Sarah Kiff +9 more
doaj +1 more source
PLoS ONE, 2021 Diazoxide is the first-line drug for treating hyperinsulinism and the only pharmacological agent approved for hyperinsulinism by the Federal Drug Administration.
Xiaohong Chen +4 more
doaj +1 more source
Frontiers in Medicine, 2023 The Drug Rash with Eosinophilia and Systemic Symptoms (DRESS) syndrome can be potentially life-threatening. The diagnosis is sometimes difficult since the clinical manifestations may be incomplete or non-specific.
Najoua Lassoued +10 more
doaj +1 more source
A combination of nifedipine and octreotide treatment in an hyperinsulinemic hypoglycemic infant. [PDF]
, 2016 PublishedResearch Support, Non-U.S. Gov'tThis is the final version of the article. Available from Galenos Publishing via the DOI in this record.Hyperinsulinemic hypoglycemia (HH) is the commonest cause of persistent hypoglycemia in the neonatal and ...
Akcurin, S +5 more
core +1 more source
Glimepiride, a novel sulfonylurea, does not abolish myocardial protection afforded by either ischemic preconditioning or diazoxide [PDF]
, 2001 Background: The sulfonylurea glibenclamide (Glib) abolishes the cardioprotective effect of ischemic preconditioning (IP), presumably by inhibiting mitochondrial KATP channel opening in myocytes. Glimepiride (Glim) is a new sulfonylurea reported to affect
Baxter, G.F. +5 more
core
Hyperglycemia modulates extracellular amyloid-β concentrations and neuronal activity in vivo [PDF]
, 2015 Epidemiological studies show that patients with type 2 diabetes (T2DM) and individuals with a diabetes-independent elevation in blood glucose have an increased risk for developing dementia, specifically dementia due to Alzheimer’s disease (AD).
Cirrito +17 more
core +2 more sources
Opening closed inward rectifier potassium channel doors
British Journal of Pharmacology, EarlyView.Inwardly rectifying potassium (KIR) channels are essential regulators of membrane potential in excitable and non‐excitable tissues. Although KIR channels exhibit a biophysical preference for potassium influx due to voltage‐dependent block of outward current by polyamines and Mg2+, under physiological conditions, they predominantly mediate K+ efflux ...
Anna Stary‐Weinzinger +3 more
wiley +1 more source
Preconditioning with associated blocking of Ca2+ inflow alleviates hypoxia-induced damage to pancreatic β-cells. [PDF]
PLoS ONE, 2013 Beta cells of pancreatic islets are susceptible to functional deficits and damage by hypoxia. Here we aimed to characterize such effects and to test for and pharmacological means to alleviate a negative impact of hypoxia.Rat and human pancreatic islets ...
Zuheng Ma +6 more
doaj +1 more source
Anatolian Journal of Cardiology, 2023 Background: Myocardial infarction is associated with the autophagy and apoptosis of cardiomyocytes, and the protein kinase B/mammalian target of rapamycin (AKT/mTOR) pathway plays a crucial role in this mechanism.
Qian Zeng +10 more
doaj +1 more source
Adenosine triphosphate-sensitive potassium channel Kir subunits implicated in cardioprotection by diazoxide [PDF]
, 2015 BACKGROUND: ATP-sensitive potassium (K(ATP)) channel openers provide cardioprotection in multiple models. Ion flux at an unidentified mitochondrial K(ATP) channel has been proposed as the mechanism.
Henn, Matthew C +6 more
core +2 more sources