Results 41 to 50 of about 14,174 (227)

Nifedipine in Congenital Hyperinsulinism - A Case Report. [PDF]

, 2016
PublishedJournal ArticleThis is the final version of the article. Available from Galenos Yayınevi via the DOI in this record.Congenital hyperinsulinism (CHI) is the commonest cause of persistent hypoglycemia in neonates.
Basak, D, Chatterjee, S, Flanagan, SE, Hussain, K, Khawash, P   +4 more
core   +1 more source

Dill extract induces elastic fiber neosynthesis and functional improvement in the ascending aorta of aged mice with reversal of age-dependent cardiac hypertrophy and involvement of lysyl oxidase-like-1 [PDF]

, 2020
Elastic fibers (90% elastin, 10% fibrillin-rich microfibrils) are synthesized only in early life and adolescence mainly by the vascular smooth muscle cells through the cross-linking of its soluble precursor, tropoelastin.
Boyle, Walter A, Boëté, Quentin, Cenizo, Valérie, Faury, Gilles, Fhayli, Wassim, Jacob, Marie-Paule, Kihal, Nadjib, Sommer, Pascal   +7 more
core   +3 more sources

Partial diazoxide responsiveness in a neonate with hyperinsulinism due to homozygous ABCC8 mutation

Endocrinology, Diabetes & Metabolism Case Reports, 2019
We report a case of partial diazoxide responsiveness in a child with severe congenital hyperinsulinaemic hypoglycaemia (CHI) due to a homozygous ABCC8 mutation.
Sarah Kiff, Carolyn Babb, Maria Guemes, Antonia Dastamani, Clare Gilbert, Sarah E Flanagan, Sian Ellard, John Barton, M Dattani, Pratik Shah   +9 more
doaj   +1 more source

Efficacy and safety of diazoxide for treating hyperinsulinemic hypoglycemia: A systematic review and meta-analysis.

PLoS ONE, 2021
Diazoxide is the first-line drug for treating hyperinsulinism and the only pharmacological agent approved for hyperinsulinism by the Federal Drug Administration.
Xiaohong Chen, Lifang Feng, Hui Yao, Luhong Yang, Yuan Qin   +4 more
doaj   +1 more source

Preconditioning with associated blocking of Ca2+ inflow alleviates hypoxia-induced damage to pancreatic β-cells. [PDF]

PLoS ONE, 2013
Beta cells of pancreatic islets are susceptible to functional deficits and damage by hypoxia. Here we aimed to characterize such effects and to test for and pharmacological means to alleviate a negative impact of hypoxia.Rat and human pancreatic islets ...
Zuheng Ma, Noah Moruzzi, Sergiu-Bogdan Catrina, Ingrid Hals, José Oberholzer, Valdemar Grill, Anneli Björklund   +6 more
doaj   +1 more source

ATP-Sensitive Potassium Channel-Mediated Lactate Effect on Orexin Neurons: Implications for Brain Energetics during Arousal [PDF]

, 2010
Active neurons have a high demand for energy substrate, which is thought to be mainly supplied as lactate by astrocytes. Heavy lactate dependence of neuronal activity suggests that there may be a mechanism that detects and controls lactate levels and/or ...
Hirasawa, Michiru, Parsons, Matthew P.
core   +1 more source

A posteriori diagnosis of DRESS syndrome induced by diazoxide in a patient with an insulinoma: a case report and review of the literature

Frontiers in Medicine, 2023
The Drug Rash with Eosinophilia and Systemic Symptoms (DRESS) syndrome can be potentially life-threatening. The diagnosis is sometimes difficult since the clinical manifestations may be incomplete or non-specific.
Najoua Lassoued, Najoua Lassoued, Wafa Alaya, Sondos Arfa, Mouna Korbi, Ines Lassoued, Soumaya Ben Amor, Fatma Zaouali, Zayneb Farhat, Jihen Chelly, Mohamed Habib Sfar   +10 more
doaj   +1 more source

Loss of AMP-activated protein kinase alpha 2 subunit in mouse beta-cells impairs glucose-stimulated insulin secretion and inhibits their sensitivity to hypoglycaemia [PDF]

, 2010
AMPK (AMP-activated protein kinase) signalling plays a key role in whole-body energy homoeostasis, although its precise role in pancreatic β-cell function remains unclear.
Affourtit, Ashcroft, Benoit Viollet, Bosi, Brand, Cantley, Chan, Chang, Choudhury, Claret, Cool, Craig Beall, David Carling, da Silva Xavier, Del Guerra, Dominic J. Withers, Fu, Gleason, Gloyn, Gloyn, Granot, Hind Al-Qassab, Johnson, Kaisa Piipari, Khan, Krauss, Leclerc, Lim, MacDonald, Marchetti, Mark A. Smith, Matschinsky, Meakin, Michael L. J. Ashford, Miki, Mirshamsi, Mukhtar, Nadeene Parker, Ning, Ostenson, Parton, Pi, Richards, Robertson, Salt, Seghers, Thorens, Vincent, Viollet, Viollet, Wajchenberg, Walker, Wang, Wang, Xue, Yamada, Zhang, Zhang, Zhang   +58 more
core   +8 more sources

An OGT Missense Variant With Impaired Enzyme Activity in a Child With Severe Developmental Delay and Hepatoblastoma

American Journal of Medical Genetics Part A, Volume 200, Issue 2, Page 502-510, February 2026.
ABSTRACT O‐GlcNAc transferase (OGT) and its antagonist O‐GlcNAcase (OGA) regulate protein O‐GlcNAcylation, a highly conserved post‐translational modification involved in metabolic sensing. Pathogenic variants in the OGT gene cause an X‐linked congenital disorder of glycosylation (OGT‐CDG) presenting developmental delay, hypotonia, intellectual ...
Alfonso Manuel D'Alessio, Huijie Yuan, Leandro Raul Soria, Sara Basse Hansen, Iolanda Boffa, Paola Arena, Benedetta Attianese, Maureen. O'Sullivan, Noelle Cullinan, Lewis Pang, Daan Marinus Ferdinand van Aalten, Nicola Brunetti‐Pierri, Sally Ann Lynch   +12 more
wiley   +1 more source

Glimepiride, a novel sulfonylurea, does not abolish myocardial protection afforded by either ischemic preconditioning or diazoxide [PDF]

, 2001
Background: The sulfonylurea glibenclamide (Glib) abolishes the cardioprotective effect of ischemic preconditioning (IP), presumably by inhibiting mitochondrial KATP channel opening in myocytes. Glimepiride (Glim) is a new sulfonylurea reported to affect
Baxter, G.F., Lawrence, C.L., Maddock, H.L., Mocanu, M.M., Standen, N.B., Yellon, D.M.   +5 more
core