Results 51 to 60 of about 13,368 (258)

ATP-sensitive potassium transport in rat brain mitochondria is highly sensitive to mK(ATP) channels openers: a light scattering study [PDF]

The Ukrainian Biochemical Journal, 2020
The aspects of ATP-sensitive K+ transport regulation by mitochondrial K+,ATP-sensitive (mKATP) channels openers are important for understanding the properties of these channels.
O. V. Akopova, L. I. Kolchinskaya, V. I. Nosar, A. N. Smirnov, L. V. Bratus   +4 more
doaj   +1 more source

Nifedipine in Congenital Hyperinsulinism - A Case Report. [PDF]

, 2016
PublishedJournal ArticleThis is the final version of the article. Available from Galenos Yayınevi via the DOI in this record.Congenital hyperinsulinism (CHI) is the commonest cause of persistent hypoglycemia in neonates.
Basak, D, Chatterjee, S, Flanagan, SE, Hussain, K, Khawash, P   +4 more
core   +1 more source

Phosphomannomutase 2 hyperinsulinemia: Recent advances of genetic pathogenesis, diagnosis, and management

Frontiers in Endocrinology, 2023
Congenital hyperinsulinemia (CHI), is a clinically heterogeneous disorder that presents as a major cause of persistent and recurrent hypoglycemia during infancy and childhood. There are 16 subtypes of CHI-related genes.
Congli Chen, Yanmei Sang
doaj   +1 more source

Glimepiride, a novel sulfonylurea, does not abolish myocardial protection afforded by either ischemic preconditioning or diazoxide [PDF]

, 2001
Background: The sulfonylurea glibenclamide (Glib) abolishes the cardioprotective effect of ischemic preconditioning (IP), presumably by inhibiting mitochondrial KATP channel opening in myocytes. Glimepiride (Glim) is a new sulfonylurea reported to affect
Baxter, G.F., Lawrence, C.L., Maddock, H.L., Mocanu, M.M., Standen, N.B., Yellon, D.M.   +5 more
core  

Diazoxide attenuates autoimmune encephalomyelitis and modulates lymphocyte proliferation and dendritic cell functionality [PDF]

, 2014
Activation of mitochondrial ATP-sensitive potassium (KATP) channels is postulated as an effective mechanism to confer cardio and neuroprotection, especially in situations associated to oxidative stress.
A Freund, A Quintana, A. Wegner, AR Gocke, B Almolda, B. Wappenhans, BD Trapp, C Beeton, C Steinhauser, C. Chanvillard, C. Infante-Duarte, CG Nichols, DW Busija, E Carrasco-Marin, E Holmuhamedov, EJ Rahn, F Zhou, G Toldi, H Wang, I Tsunoda, J Goverman, J Wang, J Xie, J. F. Espinosa-Parrilla, JR Mora, K Yamada, L Huang, LC Alberici, M Ichinose, M Moghtadaei, M. J. Rodríguez, M. Pugliese, MJ Carson, MJ Carson, MJ Rodriguez, ML Olsen, N Virgili, N. Virgili, NA Marshall, P Shrikant, P. Mancera, PM Gallo, R Mannhold, RA O’Connor, S Bittner, S Ghanshani, SD Skaper, SG Meuth, SI Judge, SI Judge, T Miura, T Yasu, V Abadie, X Liu, Z Kuras   +54 more
core   +2 more sources

Ketotic Hypoglycaemia Following Sleeve Gastrectomy

Clinical Endocrinology, EarlyView.
ABSTRACT Post‐bariatric surgery hypoglycaemia is typically mediated by hyperinsulinaemia, although the exact mechanisms are incompletely understood. Two cases of non‐insulin mediated, ketotic hypoglycaemia following sleeve gastrectomy are presented. After fasting for 40 and 65 h, respectively, both patients developed symptomatic hypoglycaemia, with ...
Jinwen He, Liza Phillips, Janelle Nisbet, Adam Morton   +3 more
wiley   +1 more source

Adverse Effects Associated with Diazoxide Use in Neonates [PDF]

, 2022
Introduction: Diazoxide is the first-line treatment used to manage infants and children with hypoglycemia secondary to hyperinsulinemic hypoglycemia (HH), after initial stabilization of blood glucose.
Begun MD, Zoe, Graber DO, Evan, Hunter PhD, Krystal, Kushnir MD, Alla   +3 more
core   +1 more source

Multicenter Study on the Clinical Characteristics, Diagnosis, and Treatment Outcomes of Insulinoma: Insights From 15 Medical Centres

Clinical Endocrinology, EarlyView.
ABSTRACT Objective This study aimed to evaluate the clinical characteristics, diagnostic approaches, and treatment outcomes of insulinoma patients from diverse regions across the country. We conducted a retrospective analysis of medical records from 76 adult patients diagnosed with insulinoma between 2018 and 2023 at 15 medical centres.
Şenay Topsakal, Güzin Fidan Yaylalı, Zeliha Yarar, Fatma Avcı Merdin, Seda Karslı, Sema Çiftçi, Mehmet Sercan Ertürk, Barış Önder Pamuk, Ayşe Özdemir Yavuz, Kader Uğur, Ogün Bilen, Sayid Shafi Zuhur, İsmail Engin, Mehmet Güven, Fazıl Mustafa Cesur, Sevgül Fakı, Şefika Burçak Polat, Bekir Çakır, Hatice Özışık, Gökçen Ünal Kocabaş, Mehmet Erdoğan, Şevki Çetinkalp, İlkcan Çerçi Koçar, Esen Akbay, Sema Yarman   +24 more
wiley   +1 more source

Diazoxide and moderate‐intensity exercise improve skeletal muscle function by decreasing oxidants and enhancing antioxidant defenses in hypertensive male rats

Physiological Reports
High sodium intake is decisive in the incidence increase and prevalence of hypertension, which has an impact on skeletal muscle functionality. Diazoxide is an antihypertensive agent that inhibits insulin secretion and is an opener of KATP channels ...
Estefanía Bravo Sánchez, César J. Nolasco Ruíz, Mariana Gómez‐Barroso, Christian Cortés Rojo, Alain R. Rodríguez Orozco, Alfredo Saavedra Molina, Salvador Manzo Ávalos, Rocío Montoya Pérez   +7 more
doaj   +1 more source

Heterozygous Insulin Receptor (INSR) Mutation Associated with Neonatal Hyperinsulinemic Hypoglycaemia and Familial Diabetes Mellitus: Case Series

JCRPE, 2020
Mutations in the insulin receptor (INSR) gene are associated with insulin resistance and hyperglycaemia. Various autosomal dominant heterozygous INSR mutations leading to hyperinsulinemic hypoglycaemia (HH) have been described in adults and children ...
Aashish Sethi, Nicola Foulds, Sarah Ehtisham, Syed Haris Ahmed, Jayne Houghton, Kevin Colclough, Mohammed Didi, Sarah E. Flanagan, Senthil Senniappan   +8 more
doaj   +1 more source