Results 51 to 60 of about 14,174 (227)

A combination of nifedipine and octreotide treatment in an hyperinsulinemic hypoglycemic infant. [PDF]

, 2016
PublishedResearch Support, Non-U.S. Gov'tThis is the final version of the article. Available from Galenos Publishing via the DOI in this record.Hyperinsulinemic hypoglycemia (HH) is the commonest cause of persistent hypoglycemia in the neonatal and ...
Akcurin, S, Bircan, I, Durmaz, E, Ellard, S, Flanagan, SE, Parlak, M   +5 more
core   +1 more source

Executive Summary of the 2024 Philippine Clinical Practice Guidelines on the Diagnosis and Management of Acute Severe Blood Pressure Elevation

The Journal of Clinical Hypertension, Volume 28, Issue 2, February 2026.
ABSTRACT A recent survey in the Philippines, PRESYON‐4, showed increasing prevalence of hypertension from 22% in the 1990s to 37% in 2021, of which only 52% were aware of their diagnosis. While rates of treatment and adherence were 68% and 86%, respectively, the rate of BP control was low at 37%. Furthermore, there remained a high degree of unawareness
Deborah Ignacia D. Ona, Felix Eduardo Punzalan, Raymond V. Oliva, Ma. Sergia Fatima Sucaldito, Noel Espallardo, Richard Santos, Hannah Almenario, Karl Murillo, Valentin Dones III, Elmer Jasper Llanes, Lourdes Ella Santos, Maria Cristina San Jose, Alyssa Samantha Fusingan‐Peralta, Rommel Bataclan, Maria Katrina Mata, Pauline Convocar, Aurelia Leus, Gilbert Vilela   +17 more
wiley   +1 more source

Effects of Mitochondrial ATP-Sensitive Potassium Channel in Rats with Acute Myocardial Infarction and Its Association with the AKT/mTOR Pathway

Anatolian Journal of Cardiology, 2023
Background: Myocardial infarction is associated with the autophagy and apoptosis of cardiomyocytes, and the protein kinase B/mammalian target of rapamycin (AKT/mTOR) pathway plays a crucial role in this mechanism.
Qian Zeng, Long-Dan Zhang, Quan-fang Chen, Wei Wang, Zhou Huang, Dong-Ling Huang, Fan Wang, Feng Yang, Jifei Nong, Jie Yang, Jincheng Zeng   +10 more
doaj   +1 more source

Hyperglycemia modulates extracellular amyloid-β concentrations and neuronal activity in vivo [PDF]

, 2015
Epidemiological studies show that patients with type 2 diabetes (T2DM) and individuals with a diabetes-independent elevation in blood glucose have an increased risk for developing dementia, specifically dementia due to Alzheimer’s disease (AD).
Cirrito, Courtney L. Sutphen, Craft, David M. Holtzman, DeFronzo, Dunn-Meynell, Emily E. Caesar, Holtzman, Jankowsky, Liu, Marcus E. Raichle, Molly Stanley, Roh, Ronaldo Perez, Shannon L. Macauley, Steven A. Yamada, Thomas E. Mahan, Uehara   +17 more
core   +2 more sources

NERP‐4–Deleted VGF Impairs β‐Cell Granulogenesis and Insulin Secretion

The FASEB Journal, Volume 39, Issue 24, 31 December 2025.
Neuroendocrine regulatory peptide‐4 (NERP‐4) processed from the VGF promotes insulin secretion and β‐cell maintenance by acting on the amino acid transporter SNAT2. VGF△NERP‐4 impaired β‐cell granulogenesis and granule replenishment needed for the second‐phase insulin secretion.
Weidong Zhang, Yuki Nakazato, Naoto Minamino, Nobuaki Okumura, Ayako Miura, Takefusa Tarusawa, Hiroki Mizukami, Hideyuki Sakoda, Masamitsu Nakazato   +8 more
wiley   +1 more source

Clinical and Molecular Characterisation Of Hyperinsulinaemic Hypoglycaemia In Infants Born Small-For-Gestational Age [PDF]

, 2013
OBJECTIVE: To characterise the phenotype and genotype of neonates born small-for-gestational age (SGA; birth weight 6 months. Normoglycaemia on diazoxide
Arya, Ved Bhushan, Ellard, Sian, Flanagan, Sarah E, Hamilton-Shield, Julian P, Hussain, Khalid, Kapoor, Ritika R, Kumaran, Anitha   +6 more
core   +2 more sources

Stability of Diazoxide in Extemporaneously Compounded Oral Suspensions. [PDF]

PLoS ONE, 2016
The objective of this study was to evaluate the stability of diazoxide in extemporaneously compounded oral suspensions. Oral suspensions of diazoxide 10 mg/mL were prepared from either bulk drug or capsules dispersed in either Oral Mix or Oral Mix Sugar ...
Mihaela Friciu, Sarra Zaraa, V Gaëlle Roullin, Grégoire Leclair   +3 more
doaj   +1 more source

Adenosine triphosphate-sensitive potassium channel Kir subunits implicated in cardioprotection by diazoxide [PDF]

, 2015
BACKGROUND: ATP-sensitive potassium (K(ATP)) channel openers provide cardioprotection in multiple models. Ion flux at an unidentified mitochondrial K(ATP) channel has been proposed as the mechanism.
Henn, Matthew C, Janjua, M. Burhan, Kanter, Evelyn M, Lawton, Jennifer S, Makepeace, Carol M, Nichols, Colin G, Schuessler, Richard B   +6 more
core   +2 more sources

Insulinoma in a dog (Canis lupus familiaris) with concurrent non‐cardiogenic pulmonary oedema

Veterinary Record Case Reports, Volume 13, Issue 4, December 2025.
Abstract A 12‐year‐old, female, neutered beagle presented with hypoglycaemia, sudden‐onset non‐ambulatory tetraparesis and a single tonic‐clonic seizure. Computed tomography revealed a pancreatic nodule, consistent with an insulinoma, an enlarged hepatic lymph node and ground‐glass attenuation of the lung parenchyma, most consistent with non ...
Dylan O’ Toole, Julia Riggs, Tom Butler, Chantelle Franklin, Hannah Wong, Barbara Skelly   +5 more
wiley   +1 more source

Diazoxide and moderate‐intensity exercise improve skeletal muscle function by decreasing oxidants and enhancing antioxidant defenses in hypertensive male rats

Physiological Reports
High sodium intake is decisive in the incidence increase and prevalence of hypertension, which has an impact on skeletal muscle functionality. Diazoxide is an antihypertensive agent that inhibits insulin secretion and is an opener of KATP channels ...
Estefanía Bravo Sánchez, César J. Nolasco Ruíz, Mariana Gómez‐Barroso, Christian Cortés Rojo, Alain R. Rodríguez Orozco, Alfredo Saavedra Molina, Salvador Manzo Ávalos, Rocío Montoya Pérez   +7 more
doaj   +1 more source