Results 61 to 70 of about 11,974 (182)

Autophagy Induced by Ischemic Preconditioning is Essential for Cardioprotection [PDF]

, 2010
Based on growing evidence linking autophagy to preconditioning, we tested the hypothesis that autophagy is necessary for cardioprotection conferred by ischemic preconditioning (IPC). We induced IPC with three cycles of 5 min regional ischemia alternating
Chengqun Huang, Smadar Yitzhaki, Cynthia N. Perry, Wayne Liu, Zoltan Giricz, Robert M. Mentzer, Roberta A. Gottlieb   +6 more
core   +2 more sources

An OGT Missense Variant With Impaired Enzyme Activity in a Child With Severe Developmental Delay and Hepatoblastoma

American Journal of Medical Genetics Part A, Volume 200, Issue 2, Page 502-510, February 2026.
ABSTRACT O‐GlcNAc transferase (OGT) and its antagonist O‐GlcNAcase (OGA) regulate protein O‐GlcNAcylation, a highly conserved post‐translational modification involved in metabolic sensing. Pathogenic variants in the OGT gene cause an X‐linked congenital disorder of glycosylation (OGT‐CDG) presenting developmental delay, hypotonia, intellectual ...
Alfonso Manuel D'Alessio, Huijie Yuan, Leandro Raul Soria, Sara Basse Hansen, Iolanda Boffa, Paola Arena, Benedetta Attianese, Maureen. O'Sullivan, Noelle Cullinan, Lewis Pang, Daan Marinus Ferdinand van Aalten, Nicola Brunetti‐Pierri, Sally Ann Lynch   +12 more
wiley   +1 more source

Executive Summary of the 2024 Philippine Clinical Practice Guidelines on the Diagnosis and Management of Acute Severe Blood Pressure Elevation

The Journal of Clinical Hypertension, Volume 28, Issue 2, February 2026.
ABSTRACT A recent survey in the Philippines, PRESYON‐4, showed increasing prevalence of hypertension from 22% in the 1990s to 37% in 2021, of which only 52% were aware of their diagnosis. While rates of treatment and adherence were 68% and 86%, respectively, the rate of BP control was low at 37%. Furthermore, there remained a high degree of unawareness
Deborah Ignacia D. Ona, Felix Eduardo Punzalan, Raymond V. Oliva, Ma. Sergia Fatima Sucaldito, Noel Espallardo, Richard Santos, Hannah Almenario, Karl Murillo, Valentin Dones III, Elmer Jasper Llanes, Lourdes Ella Santos, Maria Cristina San Jose, Alyssa Samantha Fusingan‐Peralta, Rommel Bataclan, Maria Katrina Mata, Pauline Convocar, Aurelia Leus, Gilbert Vilela   +17 more
wiley   +1 more source

Hyperinsulinism in short-chain L-3-hydroxyacyl-CoA dehydrogenase deficiency reveals the importance of beta-oxidation in insulin secretion [PDF]

, 2001
A female infant of nonconsanguineous Indian parents presented at 4 months with a hypoglycemic convulsion. Further episodes of hypoketotic hypoglycemia were associated with inappropriately elevated plasma insulin concentrations.
Aynsley-Green, A, Berger, R, Clayton, PT, Datta, V, Eaton, S, Edginton, M, Hussain, K, Krywawych, S, Malingre, HEM, van den Berg, IET   +9 more
core  

UCP2 Regulates the Glucagon Response to Fasting and Starvation [PDF]

, 2013
Glucagon is important for maintaining euglycemia during fasting/starvation, and abnormal glucagon secretion is associated with type 1 and type 2 diabetes; however, the mechanisms of hypoglycemia-induced glucagon secretion are poorly understood.
Allister, Emma M., Gaisano, Herbert Y., Gilon, Patrick, Hardy, Alexandre B., Herrera, Pedro L., Kong, Dong, Lowell, Bradford B., Prentice, Kacey J., Robson-Doucette, Christine A., Sultan, Sobia, Wheeler, Michael B.   +10 more
core   +2 more sources

Oncology drug repurposing as a blueprint for Alzheimer's therapy

Alzheimer's &Dementia: Translational Research &Clinical Interventions, Volume 12, Issue 1, January/March 2026.
Abstract Alzheimer's disease (AD) imposes substantial personal, social, and economic burdens, yet current therapies provide only modest slowing of clinical decline. Recent approvals of amyloid‐targeting antibodies confirm target engagement but also expose the limitations of single‐target strategies in a disease shaped by interacting processes ...
Viswanath Das, Marián Hajdúch
wiley   +1 more source

Clinical and molecular data from 61 Brazilian cases of Congenital Hyperinsulinemic Hypoglycemia [PDF]

, 2015
Objective: To study the clinical and molecular characteristics of a sample of Brazilian patients with Congenital Hyperinsulinemic Hypoglycemia (CHH).Methods: Electronic message was sent to members from Endocrinology Department-Brazilian Society of ...
Della Manna, Thais, Guerra, Gil, Liberatore, Raphael Del Roio, Martinelli Junior, Carlos Eduardo, Ramos, Priscila Manzini, Silva, Ivani Novato   +5 more
core   +3 more sources

Non‐Islet Cell Tumor Hypoglycemia Secondary to Gastrointestinal Stromal Tumor: A Rare Paraneoplastic Presentation

Case Reports in Oncological Medicine, Volume 2026, Issue 1, 2026.
We present a rare case of non‐islet cell tumor hypoglycemia (NICTH) in a 52‐year‐old female with metastatic gastrointestinal stromal tumor (GIST). Her hypoglycemia worsened alongside her disease burden, reaching Grade 4 and mirroring the rapid progression of her cancer.
K. Elmusharaf, H. Ismail, O. M. Fitzpatrick, C. Moloney, W. Grogan, Jose I. Mayordomo   +5 more
wiley   +1 more source

Oral administration of the K_ATP channel opener diazoxide ameliorates disease progression in a murine model of multiple sclerosis

Journal of Neuroinflammation, 2011
Background Multiple Sclerosis (MS) is an acquired inflammatory demyelinating disorder of the central nervous system (CNS) and is the leading cause of nontraumatic disability among young adults.
Mahy Nicole, Rodríguez Manuel J, Gimeno-Bayon Javier, Pastén-Zamorano Andrea, Mancera Pilar, Espinosa-Parrilla Juan F, Virgili Noemí, Pugliese Marco   +7 more
doaj   +1 more source

Heterozygous Insulin Receptor (INSR) Mutation Associated with Neonatal Hyperinsulinemic Hypoglycaemia and Familial Diabetes Mellitus: Case Series

JCRPE, 2020
Mutations in the insulin receptor (INSR) gene are associated with insulin resistance and hyperglycaemia. Various autosomal dominant heterozygous INSR mutations leading to hyperinsulinemic hypoglycaemia (HH) have been described in adults and children ...
Aashish Sethi, Nicola Foulds, Sarah Ehtisham, Syed Haris Ahmed, Jayne Houghton, Kevin Colclough, Mohammed Didi, Sarah E. Flanagan, Senthil Senniappan   +8 more
doaj   +1 more source