Results 61 to 70 of about 13,368 (258)

The role of Volatile Anesthetics in Cardioprotection: a systematic review. [PDF]

, 2012
This review evaluates the mechanism of volatile anesthetics as cardioprotective agents in both clinical and laboratory research and furthermore assesses possible cardiac side effects upon usage.
Applegate, Richard L, Krafft, Paul R, Leitzke, Arthur S, Tang, Jiping, Van Allen, Nicole R, Zhang, John H   +5 more
core   +1 more source

Adaptations to hypoxia in the vertebrate retina

The Journal of Physiology, EarlyView.
Abstract figure legend Most animals, including mammals, are susceptible to the damaging effects of hypoxia or ischaemia, where the result is neuronal cell death in the brain. By contrast, some neurons of the mammalian retina are less sensitive to hypoxia. In both brain and retina, neurons may survive if first preconditioned with ischaemia.
Michael G. Jonz
wiley   +1 more source

Congenital hyperinsulinemic hypoglycemia (HH) requiring treatment as the presenting feature of Kabuki syndrome

Clinical Case Reports, 2023
Key Clinical Message Kabuki syndrome is a congenital condition characterized by a set of facial dysmorphic features that often help the clinician to suspect the diagnosis.
Saloua Ait Souabni, Antoine Harvengt, Camille Legat, Philippe A. Lysy   +3 more
doaj   +1 more source

Glut1 Deficiency Syndrome: Novel Pathomechanisms, Current Concepts, and Challenges

Journal of Inherited Metabolic Disease, Volume 48, Issue 3, May 2025.
ABSTRACT Glut1 Deficiency Syndrome (Glut1DS) has emerged as a treatable, but complex entity. Increasing data on pathogenic mechanisms, phenotype, genotype, and ketogenic dietary therapies (KDT) are available, as summarized in this review. Many challenges remain: novel symptoms emerge and vary with age.
Joerg Klepper
wiley   +1 more source

Effect of diazoxide on Friedreich ataxia models [PDF]

Human Molecular Genetics, 2018
Friedreich ataxia (FRDA) is an inherited recessive disorder caused by a deficiency in the mitochondrial protein frataxin. There is currently no effective treatment for FRDA available, especially for neurological deficits. In this study, we tested diazoxide, a drug commonly used as vasodilator in the treatment of acute hypertension, on cellular and ...
Santoro Antonella, Anjomani Virmouni Sara, Paradies Eleonora, Villalobos Coa Valentina L, AlMahdawi Sahar, Khoo Mee, Porcelli Vito, Vozza Angelo, Perrone Mara, Denora Nunzio, Taroni Franco, Merla Giuseppe, Palmieri Luigi, Pook Mark A, Marobbio Carlo M T   +14 more
openaire   +7 more sources

Pyruvate kinase modulates the link between β‐cell fructose metabolism and insulin secretion

The FASEB Journal, Volume 39, Issue 7, 15 April 2025.
Left: Supraphysiological fructose amplifies glucose‐induced insulin secretion (GIIS) through sweet taste receptor (STR)‐mediated PLCβ2 signaling in pancreatic β‐cells. Concurrently, the phosphorylation of fructose to fructose 1‐phosphate (F1P) occurs in conjunction with the conversion of ATP to ADP. Subsequently, F1P inhibits pyruvate kinase M2 (PKM2).
Naoya Murao, Risa Morikawa, Yusuke Seino, Kenju Shimomura, Yuko Maejima, Tamio Ohno, Norihide Yokoi, Yuichiro Yamada, Atsushi Suzuki   +8 more
wiley   +1 more source

Dexmedetomidine suppresses glucose‐stimulated insulin secretion in pancreatic β‐cells

FEBS Open Bio, Volume 15, Issue 4, Page 634-646, April 2025.
Dexmedetomidine decreases insulin release and affects glucose metabolism; however, the specific mechanism remains largely unknown. This study shows clinically relevant doses of dexmedetomidine suppressed glucose‐stimulated insulin secretion. There was no significant difference in oxygen consumption rate, intracellular ATP levels, or caspase‐3/7 ...
Munenori Kusunoki, Kiichi Hirota, Tomohiro Shoji, Takeo Uba, Yoshiyuki Matsuo, Mikio Hayashi   +5 more
wiley   +1 more source

Oral administration of the K_ATP channel opener diazoxide ameliorates disease progression in a murine model of multiple sclerosis

Journal of Neuroinflammation, 2011
Background Multiple Sclerosis (MS) is an acquired inflammatory demyelinating disorder of the central nervous system (CNS) and is the leading cause of nontraumatic disability among young adults.
Mahy Nicole, Rodríguez Manuel J, Gimeno-Bayon Javier, Pastén-Zamorano Andrea, Mancera Pilar, Espinosa-Parrilla Juan F, Virgili Noemí, Pugliese Marco   +7 more
doaj   +1 more source

Suspected congenital hyperinsulinism in a Shiba Inu dog

Journal of Veterinary Internal Medicine, 2020
A 3‐month‐old male intact Shiba Inu dog was evaluated for a seizure disorder initially deemed idiopathic in origin. Seizure frequency remained unchanged despite therapeutic serum phenobarbital concentration and use of levetiracetam.
Simon Cook, Myles McKenna, Barbara Glanemann, Ranbir Sandhu, Chris Scudder   +4 more
doaj   +1 more source

Successful medical management of insulinoma with diazoxide for 27 years

Endocrinology, Diabetes & Metabolism Case Reports, 2020
Despite improvements in localisation techniques and surgical advances, some patients with insulinoma will not be cured by surgery or may not be suitable for surgery. Medical management with diazoxide is an option for such cases.
Annabelle M Warren, Duncan J Topliss, Peter Shane Hamblin   +2 more
doaj   +1 more source