Results 71 to 80 of about 11,974 (182)

NERP‐4–Deleted VGF Impairs β‐Cell Granulogenesis and Insulin Secretion

The FASEB Journal, Volume 39, Issue 24, 31 December 2025.
Neuroendocrine regulatory peptide‐4 (NERP‐4) processed from the VGF promotes insulin secretion and β‐cell maintenance by acting on the amino acid transporter SNAT2. VGF△NERP‐4 impaired β‐cell granulogenesis and granule replenishment needed for the second‐phase insulin secretion.
Weidong Zhang, Yuki Nakazato, Naoto Minamino, Nobuaki Okumura, Ayako Miura, Takefusa Tarusawa, Hiroki Mizukami, Hideyuki Sakoda, Masamitsu Nakazato   +8 more
wiley   +1 more source

A case of insulinoma effectively treated with low‐dose diazoxide

Clinical Case Reports, 2020
Diazoxide is a benzothiadiazine that can be effective in managing hypoglycemia in frail patients with surgical risk. We report here a case of insulinoma effectively treated with diazoxide, as our report will be helpful for similar cases.
Atsushi Yasuda, Toshiro Seki, Natsumi Kitajima, Tanefumi Baba, Noriko Sasaki, Yoshie Kametani, Masami Seki, Kazuko Tanaka, Masayuki Oki   +8 more
doaj   +1 more source

Az ATP-szenzitív káliumion-csatorna nyitók neuroprotektív hatásának vizsgálata újszülött malacban = The neuroprotective effect of ATP-sensitive potassium channel openers in piglets [PDF]

, 2006
A pályázat célja az mitokondriális ATP-szenzitív káliumcsatorna (mitoKATP) nyitók közé tartozó diazoxid direkt és indirekt neuroprotektív hatásának vizsgálata volt az újszülött malacban.
Domoki, Ferenc, Nagy, Krisztina
core  

Congenital hyperinsulinemic hypoglycemia (HH) requiring treatment as the presenting feature of Kabuki syndrome

Clinical Case Reports, 2023
Key Clinical Message Kabuki syndrome is a congenital condition characterized by a set of facial dysmorphic features that often help the clinician to suspect the diagnosis.
Saloua Ait Souabni, Antoine Harvengt, Camille Legat, Philippe A. Lysy   +3 more
doaj   +1 more source

Insulinoma in a dog (Canis lupus familiaris) with concurrent non‐cardiogenic pulmonary oedema

Veterinary Record Case Reports, Volume 13, Issue 4, December 2025.
Abstract A 12‐year‐old, female, neutered beagle presented with hypoglycaemia, sudden‐onset non‐ambulatory tetraparesis and a single tonic‐clonic seizure. Computed tomography revealed a pancreatic nodule, consistent with an insulinoma, an enlarged hepatic lymph node and ground‐glass attenuation of the lung parenchyma, most consistent with non ...
Dylan O’ Toole, Julia Riggs, Tom Butler, Chantelle Franklin, Hannah Wong, Barbara Skelly   +5 more
wiley   +1 more source

Suspected congenital hyperinsulinism in a Shiba Inu dog

Journal of Veterinary Internal Medicine, 2020
A 3‐month‐old male intact Shiba Inu dog was evaluated for a seizure disorder initially deemed idiopathic in origin. Seizure frequency remained unchanged despite therapeutic serum phenobarbital concentration and use of levetiracetam.
Simon Cook, Myles McKenna, Barbara Glanemann, Ranbir Sandhu, Chris Scudder   +4 more
doaj   +1 more source

The Concise Guide to PHARMACOLOGY 2025/26: Ion channels

British Journal of Pharmacology, Volume 182, Issue S1, Page S152-S241, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Jörg Striessnig, Alasdair J. Gibb, Alistair A. Mathie, Emma L. Veale, Eamonn Kelly, Chloe J. Peach, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Richard W. Aldrich, Bernard Attali, Austin M. Baggetta, Elvir Becirovic, David J. Beech, Martin Biel, Roslyn M. Bill, Ana I. Caceres, William A. Catterall, Han Chow Chua, Alex C. Conner, Henry Danahay, Paul Davies, Katrien De Clerq, Markus Delling, Francesco Di Virgilio, Simonetta Falzoni, Wei Fang, Stefanie Fenske, Anna Fortuny‐Gomez, Samuel Fountain, George K. Chandy, Mohammad‐Reza Ghovanloo, Steve A. N. Goldstein, Martin Gosling, Christian Grimm, Stephan Grissmer, Kotdaji Ha, Tim G. Hales, Verena Hammelmann, Israel Hanukoglu, Meiqin Hu, Ad P. Ijzerman, Sairam V. Jabba, Mike Jarvis, Anders A. Jensen, Sven E. Jordt, Leonard K. Kaczmarek, Stephan Kellenberger, Charles Kennedy, Brian King, Philip Kitchen, Qiang Liu, Joseph W. Lynch, Rian W. Manville, Jessica Meades, Verena Mehlfeld, Annette Nicke, Stefan Offermanns, Edward Pérez‐Reyes, Leigh D. Plant, Stephan A. Pless, Lachlan D. Rash, Dejian Ren, Hussein N. Rubaiy, Mootaz M. Salman, Werner Sieghart, Lucia G. Sivilotti, Trevor G. Smart, Terrance P. Snutch, Paolo Tammaro, Jinbin Tian, James S. Trimmer, Charlotte Van den Eynde, Paola Vergani, Joris Vriens, Stephen G. Waxman, Aguan D. Wei, Brenda T. Winn, Heike Wulff, Haoxing Xu, Fan Yang, Lixia Yue, Xiaoli Zhang, Michael Zhu   +86 more
wiley   +1 more source

Repurposed antihypertensive drugs for negative symptoms in schizophrenia: A systematic review and meta‐analysis

Psychiatry and Clinical Neurosciences, Volume 79, Issue 12, Page 784-800, December 2025.
Schizophrenia is a complex psychiatric disorder characterized by positive, negative, and general psychopathological symptoms. While antipsychotic drugs are effective for positive symptoms, they provide limited benefit for negative symptoms, which are often persistent and strongly associated with functional disability.
Thiago Carnaval, My Bui, Jesús Villoria, Dolores Rodríguez, José Manuel Menchón, Francisco Ciruela, Sebastián Videla   +6 more
wiley   +1 more source

Successful medical management of insulinoma with diazoxide for 27 years

Endocrinology, Diabetes & Metabolism Case Reports, 2020
Despite improvements in localisation techniques and surgical advances, some patients with insulinoma will not be cured by surgery or may not be suitable for surgery. Medical management with diazoxide is an option for such cases.
Annabelle M Warren, Duncan J Topliss, Peter Shane Hamblin   +2 more
doaj   +1 more source

Insulin trafficking in a glucose responsive engineered human liver cell line is regulated by the interaction of ATP-sensitive potassium channels and voltage- gated calcium channels [PDF]

, 2013
Type I diabetes is caused by the autoimmune destruction of pancreatic beta (â) cells [1]. Current treatment requires multiple daily injections of insulin to control blood glucose levels.
An, T, Castro, LM, Ch'ng, E, Elgundi, Z, Liu, GJ, Lutherborrow, M, Martin, DK, Nicholson, GM, O'Brien, B, Simpson, AM, Swan, MA, Tao, CZ, Ting, HJ, Torpy, FR, Tuch, BE   +14 more
core   +1 more source