Results 71 to 80 of about 14,174 (227)

Pancreatic endocrine and exocrine function in children following near-total pancreatectomy for diffuse congenital hyperinsulinism. [PDF]

, 2016
Published onlineJournal ArticleCONTEXT: Congenital hyperinsulinism (CHI), the commonest cause of persistent hypoglycaemia, has two main histological subtypes: diffuse and focal.
Alam, S, Arya, VB, Demirbilek, H, Ellard, S, Flanagan, SE, Hussain, K, Senniappan, S   +6 more
core   +1 more source

Mesencephalic Astrocyte‐Derived Neurotrophic Factor Binds BAX to Preserve Mitochondrial Homeostasis and Energy Metabolism for Relieving Myocardial Hypertrophy

Advanced Science, Volume 12, Issue 40, October 27, 2025.
MANF in cardiomyocytes interacts with BAX to impede BAX mitochondrial translocation and cytochrome c release, further stabilizing mitochondrial structure and energy supply to relieve myocardial apoptosis and hypertrophy, which indicates MANF as a novel cardioprotective factor to have a promising clinical application for myocardial hypertrophy ...
Dong Wang, Xinru Zhang, Baolong Wang, Haipeng Li, Dongshuo Xu, Yun Yang, Jialu Zhang, Wenbing Wang, Ren Zhang, Xinyu Wang, Yunfeng Cai, Shiyu Cao, Chao Hou, Changhui Wang   +13 more
wiley   +1 more source

Heterozygous Insulin Receptor (INSR) Mutation Associated with Neonatal Hyperinsulinemic Hypoglycaemia and Familial Diabetes Mellitus: Case Series

JCRPE, 2020
Mutations in the insulin receptor (INSR) gene are associated with insulin resistance and hyperglycaemia. Various autosomal dominant heterozygous INSR mutations leading to hyperinsulinemic hypoglycaemia (HH) have been described in adults and children ...
Aashish Sethi, Nicola Foulds, Sarah Ehtisham, Syed Haris Ahmed, Jayne Houghton, Kevin Colclough, Mohammed Didi, Sarah E. Flanagan, Senthil Senniappan   +8 more
doaj   +1 more source

Adiantum capillus‐veneris: A Comprehensive Review of Its Medicinal Properties, Bioactive Compounds, and Advanced Extraction Techniques

Food Science &Nutrition, Volume 13, Issue 10, October 2025.
Adiantum capillus‐veneris (Maidenhair fern) is a medicinal plant known for its rich phytochemical composition and diverse therapeutic properties. This review highlights its antioxidant, anti‐inflammatory, antimicrobial, and antidiabetic activities, along with modern extraction techniques for isolating bioactive compounds.
Syamand Ahmed Qadir, Farhang Hameed Awlqadr, Miran Hussein Qadir, Ako Mahmood Qadir, Aryan Mahmood Faraj, Salah Abdulla Salih, Mohammed N. Saeed, Khaled Arab, Seyed Mohammad Najibi Hosseini   +8 more
wiley   +1 more source

A case of insulinoma effectively treated with low‐dose diazoxide

Clinical Case Reports, 2020
Diazoxide is a benzothiadiazine that can be effective in managing hypoglycemia in frail patients with surgical risk. We report here a case of insulinoma effectively treated with diazoxide, as our report will be helpful for similar cases.
Atsushi Yasuda, Toshiro Seki, Natsumi Kitajima, Tanefumi Baba, Noriko Sasaki, Yoshie Kametani, Masami Seki, Kazuko Tanaka, Masayuki Oki   +8 more
doaj   +1 more source

UCP2 Regulates the Glucagon Response to Fasting and Starvation [PDF]

, 2013
Glucagon is important for maintaining euglycemia during fasting/starvation, and abnormal glucagon secretion is associated with type 1 and type 2 diabetes; however, the mechanisms of hypoglycemia-induced glucagon secretion are poorly understood.
Allister, Emma M., Gaisano, Herbert Y., Gilon, Patrick, Hardy, Alexandre B., Herrera, Pedro L., Kong, Dong, Lowell, Bradford B., Prentice, Kacey J., Robson-Doucette, Christine A., Sultan, Sobia, Wheeler, Michael B.   +10 more
core   +2 more sources

Strategies for optimization of hypoglycemia rat models

Animal Models and Experimental Medicine, Volume 8, Issue 9, Page 1590-1610, September 2025.
This review focuses on rat models for studying the short‐term and long‐term effects of mild and severe hypoglycemia. We explored the physiological mechanisms to understand the consequences of hypoglycemia in rat experimental models. This study sheds light on uncovering the therapeutic potential for hypoglycemic patients and its efficacy in mitigating ...
Lee Yeong Zher, Eason Kong Qi Zheng, Rayneshia Elaura Raymond, Ye Zhen Jie, Christina Gertrude Yap   +4 more
wiley   +1 more source

Suspected congenital hyperinsulinism in a Shiba Inu dog

Journal of Veterinary Internal Medicine, 2020
A 3‐month‐old male intact Shiba Inu dog was evaluated for a seizure disorder initially deemed idiopathic in origin. Seizure frequency remained unchanged despite therapeutic serum phenobarbital concentration and use of levetiracetam.
Simon Cook, Myles McKenna, Barbara Glanemann, Ranbir Sandhu, Chris Scudder   +4 more
doaj   +1 more source

Systematic Exploration of Potential Druggable Genes for Ischemic Stroke Employing Genome‐Wide Mendelian Randomization Analysis

Brain and Behavior, Volume 15, Issue 9, September 2025.
This study identified six potential druggable genes (CALCRL, KCNJ11, NEK3, THSD1, MMP12, and HSD17B12) associated with ischemic stroke risk using a systematic druggable genome‐wide Mendelian randomization analysis. ABSTRACT Background Ischemic stroke (IS) treatment remains a significant challenge.
Peng Zhang, Yulu He, Qing Zhen, Yan Zhang   +3 more
wiley   +1 more source

Successful medical management of insulinoma with diazoxide for 27 years

Endocrinology, Diabetes & Metabolism Case Reports, 2020
Despite improvements in localisation techniques and surgical advances, some patients with insulinoma will not be cured by surgery or may not be suitable for surgery. Medical management with diazoxide is an option for such cases.
Annabelle M Warren, Duncan J Topliss, Peter Shane Hamblin   +2 more
doaj   +1 more source