Results 71 to 80 of about 13,368 (258)

Watchful waiting versus pharmacological management of small-for-gestational-age infants with hyperinsulinemic hypoglycemia

Frontiers in Endocrinology, 2023
IntroductionGiven that reports on severe diazoxide (DZX) toxicity are increasing, we aimed to understand if the short-term clinical outcomes of small-for-gestational-age (SGA) infants with hyperinsulinemic hypoglycemia (HH) managed primarily by ...
Suresh Chandran, Suresh Chandran, Suresh Chandran, Suresh Chandran, Sandra Lynn Jaya-Bodestyne, Victor Samuel Rajadurai, Victor Samuel Rajadurai, Victor Samuel Rajadurai, Victor Samuel Rajadurai, Seyed Ehsan Saffari, Mei Chien Chua, Mei Chien Chua, Mei Chien Chua, Mei Chien Chua, Fabian Yap, Fabian Yap, Fabian Yap, Fabian Yap   +17 more
doaj   +1 more source

A Five‐Year Journey to Diagnosis: Resolving Persistent Hypoglycemia Through Successful Insulinoma Resection—A Case Report

Clinical Case Reports, Volume 13, Issue 3, March 2025.
ABSTRACT Insulinoma is a rare functional pancreatic neuroendocrine tumor with an annual prevalence of 0.5–5 cases per million. It is characterized by excessive insulin secretion, leading to recurrent hypoglycemia, often diagnosed through Whipple's triad: hypoglycemic symptoms, documented low plasma glucose, and symptom resolution after glucose ...
Ankit Shrestha, Anup Pandey, Paleswan Joshi Lakhey, Biraj Baral, Aakash Pandit, Achyut Marahatta, Amisha Seth   +6 more
wiley   +1 more source

Investigating Genetic Mutations in a Large Cohort of Iranian Patients with Congenital Hyperinsulinism

JCRPE, 2022
INTRODUCTION: Congenital hyperinsulinism (CHI) is the most frequent cause of severe and persistent hypoglycaemia from birth. Understanding the pathophysiology and genetic defects behind hyperinsulinism and its complications provides clues to timely ...
Maryam Razzaghy-Azar, Saeedeh Saeedi, Sepideh Borhan Dayani, Samaneh Enayati, Farzaneh Abbasi, Somayyeh Hashemian, Peyman Eshraghi, Siroos Karimdadi, Parisa Tajdini, Rahim Vakili, Mahsa M. Amoli, Hanieh Yaghootkar   +11 more
doaj   +1 more source

Hyperinsulinaemic hypoglycaemia and diabetes mellitus due to dominant ABCC8/KCNJ11 mutations [PDF]

, 2011
Dominantly acting loss-of-function mutations in the ABCC8/KCNJ11 genes can cause mild medically responsive hyperinsulinaemic hypoglycaemia (HH). As controversy exists over whether these mutations predispose to diabetes in adulthood we investigated the ...
Ellard, S, Flanagan, SE, Harmer, SC, Hussain, K, James, CT, Kapoor, RR, McKiernan, J, Shield, JP, Thomas, AM, Tinker, A   +9 more
core   +4 more sources

Pulmonary Hypertension: Molecular Mechanisms and Clinical Studies

MedComm, Volume 6, Issue 3, March 2025.
The figure highlights the interplay of genetic and epigenetic mechanisms in pulmonary hypertension (PH) and their implications for therapeutic strategies. The genetic mechanism section features key genes implicated in PH pathogenesis. The epigenetic mechanism encompasses DNA methylation, RNA methylation, noncoding RNAs (miRNA, lncRNA), and histone ...
Joseph Adu‐Amankwaah, Qiang You, Xiaoer Liu, Jiayi Jiang, Dongqi Yang, Kuntao Liu, Jinxiang Yuan, Yanfang Wang, Qinghua Hu, Rubin Tan   +9 more
wiley   +1 more source

Hypothalamic Proopiomelanocortin Neurons Are Glucose Responsive and Express KATP Channels [PDF]

, 2003
Hypothalamic proopiomelanocortin (POMC) neurons are critical for controlling homeostatic functions in the mammal. We used a transgenic mouse model in which the POMC neurons were labeled with enhanced green fluorescent protein to perform visualized, whole-
Bosch, Martha A., Ibrahim, Nurhadi, Kelly, Martin J., Low, Malcolm J., Qiu, Jian, Rubinstein, Marcelo, RØnnekleiv, Oline K., Smart, James L.   +7 more
core   +2 more sources

A rare cause of hypoglycaemia [PDF]

, 2010
This paper describes a case study concerning a young man on treatment for psychiatric illness who developed severe episodes of hypoglycaemia. After several investigations, lithium therapy was implicated.
Sciberras, Robert
core  

A combination of nifedipine and octreotide treatment in an hyperinsulinemic hypoglycemic infant. [PDF]

, 2016
PublishedResearch Support, Non-U.S. Gov'tThis is the final version of the article. Available from Galenos Publishing via the DOI in this record.Hyperinsulinemic hypoglycemia (HH) is the commonest cause of persistent hypoglycemia in the neonatal and ...
Akcurin, S, Bircan, I, Durmaz, E, Ellard, S, Flanagan, SE, Parlak, M   +5 more
core   +1 more source

Erythematous Papules and Plaques in an Infant Receiving Glucagon Therapy

JEADV Clinical Practice, EarlyView.
Sara Al Janahi, Alya Al‐Ali, Meera Al Adawi, Yusra S. Al Ali, Harish Bangalore   +4 more
wiley   +1 more source

High‐protein vegan and omnivorous diets improve peripheral insulin sensitivity to a similar extent in people with type 2 diabetes

Diabetes, Obesity and Metabolism, Volume 27, Issue 3, Page 1143-1152, March 2025.
Abstract Background High‐protein diets have been recognized as a potential strategy in the nutritional management of type 2 diabetes (T2D). Mycoprotein is a high‐fibre, high‐protein food ingredient previously shown to improve acute glycaemic control. We determined whether incorporating mycoprotein into a high‐protein vegan diet would improve glycaemic ...
Gráinne Whelehan, Marlou L. Dirks, Sam West, Doaa R. Abdelrahman, Andrew J. Murton, Tim J. A. Finnigan, Benjamin T. Wall, Francis B. Stephens   +7 more
wiley   +1 more source