Results 81 to 90 of about 14,174 (227)

Az ATP-szenzitív káliumion-csatorna nyitók neuroprotektív hatásának vizsgálata újszülött malacban = The neuroprotective effect of ATP-sensitive potassium channel openers in piglets [PDF]

, 2006
A pályázat célja az mitokondriális ATP-szenzitív káliumcsatorna (mitoKATP) nyitók közé tartozó diazoxid direkt és indirekt neuroprotektív hatásának vizsgálata volt az újszülött malacban.
Domoki, Ferenc, Nagy, Krisztina
core  

OR10-2 Hormonal and Cardiometabolic Changes Associated with Diazoxide Choline Extended-Release (DCCR) Tablets in Patients with Prader-Willi Syndrome [PDF]

, 2022
J. Abuzzahab, Moris Angulo, Lynne M. Bird, Merlin G. Butler, N. M. Cowen, Evelien Gevers, Anthony P. Goldstone, Patricia Hirano, Laura Konczal, Melissa Lah, Verghese Mathew, Jorge Mejia Corletto, Jennifer Miller, Kathryn Obrynba, Parisa Salehi, M Guftar Shaikh, Ashley H. Shoemaker, David K. Stevenson, David Viskochil, John Wilding, Michael Woloschak, Jack A. Yanovski, Eric I. Felner   +22 more
openalex   +1 more source

Erythematous Papules and Plaques in an Infant Receiving Glucagon Therapy

JEADV Clinical Practice, Volume 4, Issue 5, Page 1263-1266, December 2025.
Sara Al Janahi, Alya Al‐Ali, Meera Al Adawi, Yusra S. Al Ali, Harish Bangalore   +4 more
wiley   +1 more source

Connexin 43 Role in Mitochondrial Transfer and Homeostasis in the Central Nervous System

Journal of Cellular Physiology, Volume 240, Issue 8, August 2025.
ABSTRACT Connexin 43 (Cx43) is a transmembrane protein involved in the assembly of gap junctions (GJs) and hemichannels (HCs), organized structures that allow the transferring of ions and small signaling molecules between cells and/or extracellular environment, thereby contributing to tissue homeostasis intercellular communication.
Anna Gervasi, Simona D'Aprile, Simona Denaro, Maria Angela Amorini, Nunzio Vicario, Rosalba Parenti   +5 more
wiley   +1 more source

Uncovering New Therapeutic Targets for Amyotrophic Lateral Sclerosis and Neurological Diseases Using Real‐World Data

Clinical Pharmacology &Therapeutics, Volume 118, Issue 1, Page 242-251, July 2025.
Although attractive for relevance to real‐world scenarios, real‐world data (RWD) is typically used for drug repurposing and not therapeutic target discovery. Repurposing studies have identified few effective options in neurological diseases such as the rare disease, amyotrophic lateral sclerosis (ALS), which has no disease‐modifying treatments ...
Mohammadali Alidoost, Jeremy Y. Huang, Georgia Dermentzaki, Anna S. Blazier, Giorgio Gaglia, Timothy R. Hammond, Francesca Frau, Mary Clare McCorry, Dimitry Ofengeim, Jennifer L. Wilson   +9 more
wiley   +1 more source

Pulmonary hypertension occurring with diazoxide use in a preterm infant with hypoglycemia

Drug, Healthcare and Patient Safety, 2019
Ranjit I Kylat Division of Neonatal-Perinatal Medicine and Developmental Biology, Department of Pediatrics, The University of Arizona, College of Medicine, Tucson, AZ, USA Abstract: Pharmacologic modulation to open the KATP channels with diazoxide is ...
Kylat RI
doaj  

Leptin-dependent Phosphorylation of PTEN Mediates Actin Restructuring and Activation of ATP-sensitive K+ Channels [PDF]

, 2009
Leptin activates multiple signaling pathways in cells, including the phosphatidylinositol 3-kinase pathway, indicating a degree of cross-talk with insulin signaling. The exact mechanisms by which leptin alters this signaling pathway and how it relates
Al-Khouri, Bain, Belsham, Bhat, Birle, Choudhury, Cole, Cole, Cross, Das, Downes, Finlay, Frame, Frübeck, Garofalo, Harvey, Harvey, Harvey, Hughes, Kim, Knobbe, Leslie, Leslie, Maccario, Maroni, Maroni, Messier, Miller, Mirshamsi, Murray, Ning, Niswender, Niswender, O'Rahilly, Pagano, Plum, Plum, Sarno, Sasaoka, Schwartz, Sutherland, Taniguchi, Torres, Valerio, Vasquez, Vasquez, Vasquez, Wang, Xu   +48 more
core   +6 more sources

Ketotic Hypoglycaemia Following Sleeve Gastrectomy

Clinical Endocrinology, Volume 103, Issue 1, Page 45-49, July 2025.
ABSTRACT Post‐bariatric surgery hypoglycaemia is typically mediated by hyperinsulinaemia, although the exact mechanisms are incompletely understood. Two cases of non‐insulin mediated, ketotic hypoglycaemia following sleeve gastrectomy are presented. After fasting for 40 and 65 h, respectively, both patients developed symptomatic hypoglycaemia, with ...
Jinwen He, Liza Phillips, Janelle Nisbet, Adam Morton   +3 more
wiley   +1 more source

Insulin trafficking in a glucose responsive engineered human liver cell line is regulated by the interaction of ATP-sensitive potassium channels and voltage- gated calcium channels [PDF]

, 2013
Type I diabetes is caused by the autoimmune destruction of pancreatic beta (â) cells [1]. Current treatment requires multiple daily injections of insulin to control blood glucose levels.
An, T, Castro, LM, Ch'ng, E, Elgundi, Z, Liu, GJ, Lutherborrow, M, Martin, DK, Nicholson, GM, O'Brien, B, Simpson, AM, Swan, MA, Tao, CZ, Ting, HJ, Torpy, FR, Tuch, BE   +14 more
core   +1 more source

Multicenter Study on the Clinical Characteristics, Diagnosis, and Treatment Outcomes of Insulinoma: Insights From 15 Medical Centres

Clinical Endocrinology, Volume 103, Issue 1, Page 57-65, July 2025.
ABSTRACT Objective This study aimed to evaluate the clinical characteristics, diagnostic approaches, and treatment outcomes of insulinoma patients from diverse regions across the country. We conducted a retrospective analysis of medical records from 76 adult patients diagnosed with insulinoma between 2018 and 2023 at 15 medical centres.
Şenay Topsakal, Güzin Fidan Yaylalı, Zeliha Yarar, Fatma Avcı Merdin, Seda Karslı, Sema Çiftçi, Mehmet Sercan Ertürk, Barış Önder Pamuk, Ayşe Özdemir Yavuz, Kader Uğur, Ogün Bilen, Sayid Shafi Zuhur, İsmail Engin, Mehmet Güven, Fazıl Mustafa Cesur, Sevgül Fakı, Şefika Burçak Polat, Bekir Çakır, Hatice Özışık, Gökçen Ünal Kocabaş, Mehmet Erdoğan, Şevki Çetinkalp, İlkcan Çerçi Koçar, Esen Akbay, Sema Yarman   +24 more
wiley   +1 more source