Results 81 to 90 of about 11,974 (182)
Loss of mTORC1 signaling alters pancreatic α cell mass and impairs glucagon secretion [PDF]
, 2017 Glucagon plays a major role in the regulation of glucose homeostasis during fed and fasting states. However, the mechanisms responsible for the regulation of pancreatic α cell mass and function are not completely understood.
Alvin C. Powers +17 more
core +1 more source
Adaptations to hypoxia in the vertebrate retina
The Journal of Physiology, Volume 603, Issue 21, Page 6517-6531, November 1, 2025.Abstract figure legend Most animals, including mammals, are susceptible to the damaging effects of hypoxia or ischaemia, where the result is neuronal cell death in the brain. By contrast, some neurons of the mammalian retina are less sensitive to hypoxia. In both brain and retina, neurons may survive if first preconditioned with ischaemia.
Michael G. Jonz
wiley +1 more source
Pulmonary hypertension occurring with diazoxide use in a preterm infant with hypoglycemia
Drug, Healthcare and Patient Safety, 2019 Ranjit I Kylat Division of Neonatal-Perinatal Medicine and Developmental Biology, Department of Pediatrics, The University of Arizona, College of Medicine, Tucson, AZ, USA Abstract: Pharmacologic modulation to open the KATP channels with diazoxide is ...
Kylat RI
doaj
Advanced Science, Volume 12, Issue 40, October 27, 2025.MANF in cardiomyocytes interacts with BAX to impede BAX mitochondrial translocation and cytochrome c release, further stabilizing mitochondrial structure and energy supply to relieve myocardial apoptosis and hypertrophy, which indicates MANF as a novel cardioprotective factor to have a promising clinical application for myocardial hypertrophy ...
Dong Wang +13 more
wiley +1 more source
Food Science &Nutrition, Volume 13, Issue 10, October 2025.Adiantum capillus‐veneris (Maidenhair fern) is a medicinal plant known for its rich phytochemical composition and diverse therapeutic properties. This review highlights its antioxidant, anti‐inflammatory, antimicrobial, and antidiabetic activities, along with modern extraction techniques for isolating bioactive compounds.
Syamand Ahmed Qadir +8 more
wiley +1 more source
Sirolimus therapy in a child with partially diazoxide-responsive hyperinsulinaemic hypoglycaemia
Endocrinology, Diabetes & Metabolism Case Reports, 2016 Hyperinsulinaemic hypoglycaemia (HH), which causes persistent neonatal hypoglycaemia, can result in neurological damage and it’s management is challenging.
Kah-Yin Loke +5 more
doaj +1 more source
Treatment with low-dose diazoxide in two growth-retarded prepubertal girls with glycogen storage disease type Ia resulted in catch-up growth [PDF]
, 2018 Two originally prepubertal girls suffering from glycogen storage disease type Ia and short stature were treated with low-dose diazoxide (3-4.8 mg/kg per day) for 7 and 4 years, respectively.
Mullis, P., Nuoffer, J., Wiesmann, U.
core
Strategies for optimization of hypoglycemia rat models
Animal Models and Experimental Medicine, Volume 8, Issue 9, Page 1590-1610, September 2025.This review focuses on rat models for studying the short‐term and long‐term effects of mild and severe hypoglycemia. We explored the physiological mechanisms to understand the consequences of hypoglycemia in rat experimental models. This study sheds light on uncovering the therapeutic potential for hypoglycemic patients and its efficacy in mitigating ...
Lee Yeong Zher +4 more
wiley +1 more source
Erythematous Papules and Plaques in an Infant Receiving Glucagon Therapy
JEADV Clinical Practice, Volume 4, Issue 5, Page 1263-1266, December 2025.
Sara Al Janahi +4 more
wiley +1 more source
Hypothalamic Proopiomelanocortin Neurons Are Glucose Responsive and Express KATP Channels [PDF]
, 2003 Hypothalamic proopiomelanocortin (POMC) neurons are critical for controlling homeostatic functions in the mammal. We used a transgenic mouse model in which the POMC neurons were labeled with enhanced green fluorescent protein to perform visualized, whole-
Bosch, Martha A. +7 more
core +2 more sources