Adenosine triphosphate-sensitive potassium channel Kir subunits implicated in cardioprotection by diazoxide [PDF]
, 2015 BACKGROUND: ATP-sensitive potassium (K(ATP)) channel openers provide cardioprotection in multiple models. Ion flux at an unidentified mitochondrial K(ATP) channel has been proposed as the mechanism.
Henn, Matthew C +6 more
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Epilepsia Open, Volume 10, Issue 1, Page 31-39, February 2025.Abstract Glucose transporter type 1 deficiency syndrome (GLUT1DS) commonly presents with early‐onset epilepsy that often resists conventional pharmacological treatment. Ketogenic diet therapy (KDT) is the preferred approach to address the underlying metabolic anomaly.
Raffaele Falsaperla +8 more
wiley +1 more source
Protection Against Cardiac Injury by Small Ca\u3csup\u3e2 +\u3c/sup\u3e-Sensitive K\u3csup\u3e+\u3c/sup\u3e Channels Identified in Guinea Pig Cardiac Inner Mitochondrial Membrane [PDF]
, 2013 We tested if small conductance, Ca2 +‐sensitive K+ channels (SKCa) precondition hearts against ischemia reperfusion (IR) injury by improving mitochondrial (m) bioenergetics, if O2‐derived free radicals are required to initiate protection via SKCa ...
Aldakkak, Mohammed +9 more
core +1 more source
Hyperglycemia modulates extracellular amyloid-β concentrations and neuronal activity in vivo [PDF]
, 2015 Epidemiological studies show that patients with type 2 diabetes (T2DM) and individuals with a diabetes-independent elevation in blood glucose have an increased risk for developing dementia, specifically dementia due to Alzheimer’s disease (AD).
Cirrito +17 more
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Pediatric Neuroendocrine Tumors in Denmark: Incidence, Management, and Outcome From 1995 to 2020
Pediatric Blood &Cancer, Volume 72, Issue 2, February 2025.ABSTRACT Background Neuroendocrine tumors (NETs), although rare, are considered one of the most common gastrointestinal and bronchopulmonary pediatric neoplasms. We aimed to determine the incidence, tumor characteristics, management, and outcome of NETs and explore the role of genetic predisposition, focusing on low and intermediate grade tumors ...
Mona P. Ankerstjerne +7 more
wiley +1 more source
Pulmonary hypertension occurring with diazoxide use in a preterm infant with hypoglycemia
Drug, Healthcare and Patient Safety, 2019 Ranjit I Kylat Division of Neonatal-Perinatal Medicine and Developmental Biology, Department of Pediatrics, The University of Arizona, College of Medicine, Tucson, AZ, USA Abstract: Pharmacologic modulation to open the KATP channels with diazoxide is ...
Kylat RI
doaj
Sirolimus therapy in a child with partially diazoxide-responsive hyperinsulinaemic hypoglycaemia
Endocrinology, Diabetes & Metabolism Case Reports, 2016 Hyperinsulinaemic hypoglycaemia (HH), which causes persistent neonatal hypoglycaemia, can result in neurological damage and it’s management is challenging.
Kah-Yin Loke +5 more
doaj +1 more source
tPA‐GFP is a reliable probe for detecting compound exocytosis in human pancreatic β‐cells
FASEB BioAdvances, Volume 7, Issue 2, February 2025.Tissue plasminogen activator tagged to GFP (tPA‐GFP) specifically enables the labelling of insulin granules, a type of large dense‐core vesicle of the pancreatic β cells. When compared to other markers widely used to understand the behavior of insulin granules, tPA enabled the detection of the most number of simple (blue arrow) and compound exocytotic (
Aishwarya A. Makam +5 more
wiley +1 more source
Possible New Strategies for the Treatment of Congenital Hyperinsulinism
Frontiers in Endocrinology, 2020 ObjectiveCongenital hyperinsulinism (CHI) is a rare disease characterized by persistent hypoglycemia as a result of inappropriate insulin secretion, which can lead to irreversible neurological defects in infants.
Jelena Sikimic +10 more
doaj +1 more source
Prompt Resolution of Hypoglycemia by Hepatic Transarterial Embolization for Malignant Insulinoma with Multiple Liver Metastases [PDF]
, 2014 A 45-year-old female who presented with loss of consciousness and a cold sweat was found to have a pancreatic tumor and multiple liver metastases. Laboratory studies showed marked hypoglycemia and inappropriately elevated serum insulin, C-peptide, and ...
Fujiwara, Hiroyasu +12 more
core +1 more source