Lineage-specific expansions of the Dicer gene family in tardigrades [PDF]
BMC GenomicsBackground RNA interference (RNAi) is an important pathway for gene regulation and immunity. Dicer is a conserved RNAi pathway protein that is found in eukaryotes, with many species expressing multiple dicer gene copies.
Bethany Weinberg +3 more
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Cleavage of Dicer protein by I7 protease during vaccinia virus infection. [PDF]
PLoS ONE, 2015 Dicer is the key component in the miRNA pathway. Degradation of Dicer protein is facilitated during vaccinia virus (VV) infection. A C-terminal cleaved product of Dicer protein was detected in the presence of MG132 during VV infection.
Jhih-Si Chen +6 more
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DICER-ARGONAUTE2 complex in continuous fluorogenic assays of RNA interference enzymes. [PDF]
PLoS ONE, 2015 Mechanistic studies of RNA processing in the RNA-Induced Silencing Complex (RISC) have been hindered by lack of methods for continuous monitoring of enzymatic activity. "Quencherless" fluorogenic substrates of RNAi enzymes enable continuous monitoring of
Mark A Bernard +2 more
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A Glimpse of “Dicer Biology” Through the Structural and Functional Perspective
Frontiers in Molecular Biosciences, 2021 The RNA interference pathway (RNAi) is executed by two core enzymes, Dicer and Argonaute, for accomplishing a tailored transcriptional and post-transcriptional gene regulation.
Sneha Paturi, Mandar V. Deshmukh
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Nuclear re-localization of Dicer in primary mouse embryonic fibroblast nuclei following DNA damage. [PDF]
PLoS Genetics, 2018 Dicer is a key component of RNA interference (RNAi) and well-known for its role in biogenesis of micro (mi)RNA in the cytoplasm. Increasing evidence suggests that mammalian Dicer is also present and active in the nucleus.
Kaspar Burger, Monika Gullerova
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Frontiers in Microbiology, 2022 RNA interference (RNAi) is divided into canonical, Dicer-dependent and non-canonical, Dicer-independent pathways according to Dicer protein dependency.
Hyunjun Lee +9 more
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Dicer Suppresses Hepatocellular Carcinoma via Interleukin-8 Pathway
Clinical Medicine Insights: Oncology, 2023 Background: Elevated level of interleukin-8 (IL-8) promotes hepatocellular carcinoma (HCC) development and contributes to poor prognosis. Previously, we have proved that Dicer inhibits HCC progression.
Xin Han +7 more
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The role of Dicer protein partners in the processing of microRNA precursors. [PDF]
PLoS ONE, 2011 One of the cellular functions of the ribonuclease Dicer is to process microRNA precursors (pre-miRNAs) into mature microRNAs (miRNAs). Human Dicer performs this function in cooperation with its protein partners, AGO2, PACT and TRBP.
Edyta Koscianska +2 more
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Dicer cooperates with p53 to suppress DNA damage and skin carcinogenesis in mice. [PDF]
PLoS ONE, 2014 Dicer is required for the maturation of microRNA, and loss of Dicer and miRNA processing has been found to alter numerous biological events during embryogenesis, including the development of mammalian skin and hair.
Stephen Lyle +5 more
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Prognostic significance of deregulated dicer expression in breast cancer. [PDF]
PLoS ONE, 2013 BACKGROUND: Dicer, an RNase III-type endonuclease, is the key enzyme involved in RNA interference and microRNA pathways. Aberrant expression of Dicer is reported in several human cancers.
Emer Caffrey +9 more
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