TWEAK Negatively Regulates Human Dicer [PDF]
Non-Coding RNA, 2016 The ribonuclease Dicer plays a central role in the microRNA pathway by processing microRNA precursors (pre-microRNAs) into microRNAs, a class of 19- to 24-nucleotide non-coding RNAs that regulate expression of ≈60% of the genes in humans. To gain further
Marine Lambert +6 more
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Prognostic significance of deregulated dicer expression in breast cancer. [PDF]
PLoS ONE, 2013 BACKGROUND: Dicer, an RNase III-type endonuclease, is the key enzyme involved in RNA interference and microRNA pathways. Aberrant expression of Dicer is reported in several human cancers.
Emer Caffrey +9 more
doaj +1 more source
Molecular Metabolism, 2022 Objective: Dicer is an enzyme that processes microRNAs (miRNAs) precursors into mature miRNAs, which have been implicated in various aspects of cancer progressions, such as clinical aggressiveness, prognosis, and survival outcomes.
Ji Min Park +10 more
doaj +1 more source
RNAase III-Type Enzyme Dicer Regulates Mitochondrial Fatty Acid Oxidative Metabolism in Cardiac Mesenchymal Stem Cells [PDF]
, 2019 Cardiac mesenchymal stem cells (C-MSC) play a key role in maintaining normal cardiac function under physiological and pathological conditions. Glycolysis and mitochondrial oxidative phosphorylation predominately account for energy production in C-MSC ...
Jin, Yue +5 more
core +1 more source
Dicer prevents genome instability in response to replication stress [PDF]
, 2019 Dicer, an endoribonuclease best-known for its role in microRNA biogenesis and RNA interference pathway, has been shown to play a role in the DNA damage response and repair of double-stranded DNA breaks (DSBs) in mammalian cells.
Barra, Viviana +6 more
core +2 more sources
Dicer-dependent biogenesis of small RNAs derived from 7SL RNA. [PDF]
PLoS ONE, 2012 It has been reported that decreased Dicer expression leads to Alu RNAs accumulation in human retinal pigmented epithelium cells, and Dicer may process the endogenous SINE/B1 RNAs (the rodent equivalent of the primate Alu RNAs) into small interfering RNAs
Yong-Feng Ren +7 more
doaj +1 more source
Role of Dicer Enzyme in the Regulation of Store Operated Calcium Entry (SOCE) in CD4+ T Cells [PDF]
, 2016 Background/Aims: Activation of T cell receptors (TCRs) in CD4+ T cells leads to a cascade of signalling reactions including increase of intracellular calcium (Ca2+) levels with subsequent Ca2+ dependent stimulation of gene expression, proliferation, cell
Abousaab, A +10 more
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Up-regulated Dicer expression in patients with cutaneous melanoma. [PDF]
PLoS ONE, 2011 BACKGROUND: MicroRNAs (miRNAs) are small non-coding RNAs (18-24 nucleotides) that have recently been shown to regulate gene expression during cancer progression.
Zhihai Ma +5 more
doaj +1 more source
Structural insights into RNA processing by the human RISC-loading complex. [PDF]
, 2009 Targeted gene silencing by RNA interference (RNAi) requires loading of a short guide RNA (small interfering RNA (siRNA) or microRNA (miRNA)) onto an Argonaute protein to form the functional center of an RNA-induced silencing complex (RISC).
AD Haase +41 more
core +2 more sources
Reversible block of mouse neural stem cell differentiation in the absence of dicer and microRNAs. [PDF]
PLoS ONE, 2010 To investigate the functions of Dicer and microRNAs in neural stem (NS) cell self-renewal and neurogenesis, we established neural stem cell lines from the embryonic mouse Dicer-null cerebral cortex, producing neural stem cell lines that lacked all ...
Therese Andersson +8 more
doaj +1 more source