Results 11 to 20 of about 75,724 (336)
TWEAK Negatively Regulates Human Dicer [PDF]
Non-Coding RNA, 2016 The ribonuclease Dicer plays a central role in the microRNA pathway by processing microRNA precursors (pre-microRNAs) into microRNAs, a class of 19- to 24-nucleotide non-coding RNAs that regulate expression of ≈60% of the genes in humans. To gain further
Marine Lambert +6 more
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Cell, 2004 The pathway of RNA interference starts when Dicer cuts dsRNA into small interfering RNAs (siRNAs) that subsequently target homologous mRNAs for destruction. microRNA processing from stem loop precursors similarly requires Dicer activity. Two papers in this issue of Cell now demonstrate that Dicer is also essential for the execution phase of RNAi and ...
Marcel Tijsterman, Ronald H.A. Plasterk
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Dicing the Disease with Dicer: The Implications of Dicer Ribonuclease in Human Pathologies [PDF]
International Journal of Molecular Sciences, 2020 Gene expression dictates fundamental cellular processes and its de-regulation leads to pathological conditions. A key contributor to the fine-tuning of gene expression is Dicer, an RNA-binding protein (RBPs) that forms complexes and affects transcription by acting at the post-transcriptional level via the targeting of mRNAs by Dicer-produced small non ...
Vicky Filippa +7 more
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The paradox of dicer in cancer [PDF]
Molecular & Cellular Oncology, 2016 Dicer has been well studied in cancer; however, deciphering its exact function in tumorigenesis continues to be a challenge. While partial suppression or truncation of Dicer promotes tumorigenesis, its complete deletion inhibits tumor growth. Here, we discuss this Dicer cancer conundrum in the context of its recently discovered role in the DNA damage ...
Vijay Swahari +2 more
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Journal of the American Society of Nephrology, 2008 We should occasionally stop, take a breath, and reflect about what is happening at the interface between medicine and science. Collectively, we are uncovering paradigms that are relevant to understanding disease at a frantic pace.
J.J. David Ho, Philip A. Marsden
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A role for Dicer in immune regulation [PDF]
The Journal of Cell Biology, 2006 Micro RNAs (miRNAs) regulate gene expression at the posttranscriptional level. Here we show that regulatory T (T reg) cells have a miRNA profile distinct from conventional CD4 T cells. A partial T reg cell–like miRNA profile is conferred by the enforced expression of Foxp3 and, surprisingly, by the activation of conventional CD4 T cells.
Bradley S. Cobb +11 more
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A Deathly DNase Activity for Dicer [PDF]
Developmental Cell, 2010 Recently reporting in Science, Nakagawa et al. describe an unexpected role for Dicer in chromosome fragmentation during apoptosis in C. elegans. They find that cleavage of DCR-1 by the caspase CED-3 redirects its regulatory activity, by destroying its dsRNase activity while activating an intrinsic DNase activity.
Katsutomo Okamura, Eric C. Lai
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The molecular architecture of human Dicer [PDF]
Nature Structural & Molecular Biology, 2012 Dicer is a multidomain enzyme that generates small RNAs for gene silencing in eukaryotes. Current understanding of Dicer structure is restricted to simple forms of the enzyme, whereas that of the large and complex Dicer in metazoans is unknown. Here we describe a new domain localization strategy developed to determine the structure of human Dicer by EM.
Bridget Carragher +5 more
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DICERing macrophages for reprogramming TAMs [PDF]
Cell Cycle, 2016 Macrophages are cells of the innate immune system that respond to external stimuli by rapidly adapting their transcriptional programs and behavior.
Squadrito Mario Leonardo +1 more
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The evolution and diversification of Dicers in plants [PDF]
FEBS Letters, 2006 Most multicellular organisms regulate developmental transitions by microRNAs, which are generated by an enzyme, Dicer. Insects and fungi have two Dicer‐like genes, and many animals have only one, yet the plant, Arabidopsis, has four. Examining the poplar and rice genomes revealed that they contain five and six Dicer‐like genes, respectively.
Neil A. Smith +7 more
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