The epigenetic regulation of Dicer and microRNA biogenesis by Panobinostat
Epigenetics, 2017 microRNAs (miRs) are small noncoding RNAs that regulate/fine tune many cellular protein networks by targeting mRNAs for either degradation or translational inhibition.
Nicholas C. Hoffend +2 more
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eLife, 2021 Some RIG-I-like receptors (RLRs) discriminate viral and cellular dsRNA by their termini, and Drosophila melanogaster Dicer-2 (dmDcr-2) differentially processes dsRNA with blunt or 2 nucleotide 3’-overhanging termini. We investigated the transient kinetic
Raushan K Singh +5 more
doaj +1 more source
Modeling recursive RNA interference. [PDF]
, 2008 An important application of the RNA interference (RNAi) pathway is its use as a small RNA-based regulatory system commonly exploited to suppress expression of target genes to test their function in vivo.
A Dillin +52 more
core +5 more sources
Zika Says No Dice to Dicer [PDF]
Cell Stem Cell, 2020 Among the common flaviviruses that infect humans, Zika virus, and the contemporary Asian strain in particular, is distinctively associated with microcephaly. Zeng et al. (2020) report in this issue of Cell Stem Cell that strong binding and inhibition of human Dicer enzyme by the capsid protein is a potential mechanism for this unique pathogenic ...
openaire +3 more sources
Rescuing dicer Defects via Inhibition of an Anti-Dicing Nuclease
Cell Reports, 2014 Genetic defects in the microRNA (miRNA) generating enzyme, dicer, are increasingly linked to disease. Loss of miRNA in dicer deficiency is thought to be due to loss of miRNA-generating activity.
Ken Asada +9 more
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Dicer expression exhibits a tissue-specific diurnal pattern that is lost during aging and in diabetes. [PDF]
PLoS ONE, 2013 Dysregulation of circadian rhythmicity is identified as a key factor in disease pathogenesis. Circadian rhythmicity is controlled at both a transcriptional and post-transcriptional level suggesting the role of microRNA (miRNA) and double-stranded RNA ...
Yuanqing Yan +9 more
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Conservation of Differential Animal MicroRNA Processing by Drosha and Dicer
Frontiers in Molecular Biosciences, 2022 In complex biochemical systems, an enzyme, protein, or RNA, symbolized as E, has hundreds or thousands of substrates or interacting partners. The relative specificity hypothesis proposes that such an E would differentially interact with and influence its
Xiaoxiao Zhang +6 more
doaj +1 more source
MicroRNAs regulate T-cell production of interleukin-9 and identify hypoxia-inducible factor-2a as an important regulator of T helper 9 and regularoty T-cell differentiation [PDF]
, 2016 MicroRNAs (miRNAs) regulate many aspects of helper T cell (Th) development and function. Here we found that they are required for the suppression of interleukin‐9 (IL‐9) expression in Th9 cells and other Th subsets. Two highly related miRNAs (miR‐15b and
Baumjohann +37 more
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Dicer is required for maintenance of adult pancreatic acinar cell identity and plays a role in Kras-driven pancreatic neoplasia. [PDF]
PLoS ONE, 2014 The role of miRNA processing in the maintenance of adult pancreatic acinar cell identity and during the initiation and progression of pancreatic neoplasia has not been studied in detail.
Yue J Wang +6 more
doaj +1 more source
In vitro binding of single-stranded RNA by human Dicer [PDF]
, 2003 While Dicer alone has been shown to form stable complexes with double-stranded RNAs and short interfering RNAs, its interactions with single-stranded RNAs (ssRNAs) have not been characterized.
Kini, Hemant K., Walton, S. Patrick
core +1 more source