Results 31 to 40 of about 77,494 (336)
MicroRNAs Regulate Ca2+ Homeostasis in Murine Embryonic Stem Cells
Cells, 2023 MicroRNAs (miRNAs) are important regulators of embryonic stem cell (ESC) biology, and their study has identified key regulatory mechanisms. To find novel pathways regulated by miRNAs in ESCs, we undertook a bioinformatics analysis of gene pathways ...
Kimberley M. Reid +7 more
doaj +1 more source
In vitro binding of single-stranded RNA by human Dicer [PDF]
, 2003 While Dicer alone has been shown to form stable complexes with double-stranded RNAs and short interfering RNAs, its interactions with single-stranded RNAs (ssRNAs) have not been characterized.
Kini, Hemant K., Walton, S. Patrick
core +1 more source
Global microRNA expression is essential for murine mast cell development in vivo [PDF]
, 2014 MicroRNAs (miRNAs) are small, noncoding RNAs that have been shown to play a critical role in normal physiology and disease, such as hematopoietic development and cancer. However, their role in mast-cell function and development is poorly understood.
Brandal, Stephanie +4 more
core +1 more source
MicroRNA processing without Dicer [PDF]
Genome Biology, 2010 The canonical processing of precursor microRNAs requires the endonuclease Dicer. A recent study shows that microRNAs can be processed independently of Dicer but instead require Argonaute 2.
Dueck, A., Meister, G.
openaire +3 more sources
Endogenous Mouse Dicer Is an Exclusively Cytoplasmic Protein.
PLoS Genetics, 2016 Dicer is a large multi-domain protein responsible for the ultimate step of microRNA and short-interfering RNA biogenesis. In human and mouse cell lines, Dicer has been shown to be important in the nuclear clearance of dsRNA as well as the establishment ...
Christian Much +7 more
doaj +1 more source
An RNAi-Based Control of Fusarium graminearum Infections Through Spraying of Long dsRNAs Involves a Plant Passage and Is Controlled by the Fungal Silencing Machinery [PDF]
, 2016 Meeting the increasing food and energy demands of a growing population will require the development of ground-breaking strategies that promote sustainable plant production.
Abdellatef, Eltayb +13 more
core +3 more sources
Journal of the American Society of Nephrology, 2008 We should occasionally stop, take a breath, and reflect about what is happening at the interface between medicine and science. Collectively, we are uncovering paradigms that are relevant to understanding disease at a frantic pace.
J J David, Ho, Philip A, Marsden
openaire +2 more sources
BioTechniques, 2010 The cleavage of double-stranded RNA (dsRNA) molecules by Dicer is a critical step in silencing genes by the RNA induced silencing complex (RISC). The development of Dicer substrates as nucleic acid–based therapeutics brings about a need to rapidly ...
Jonathan P. DiNitto +2 more
doaj +1 more source
Characterization of Dicer-deficient murine embryonic stem cells [PDF]
, 2005 Dicer is an RNase III-family nuclease that initiates RNA interference (RNAi) and related phenomena by generation of the small RNAs that determine the specificity of these gene silencing pathways.
Cheloufi, S. +4 more
core +2 more sources
Dietary sulfur amino acid restriction upregulates DICER to confer beneficial effects
Molecular Metabolism, 2019 Objective: Dietary restriction (DR) improves health and prolongs lifespan in part by upregulating type III endoribonuclease DICER in adipose tissue. In this study, we aimed to specifically test which missing dietary component was responsible for DICER ...
Beatriz A. Guerra +13 more
doaj +1 more source