Results 81 to 90 of about 75,724 (336)
RNA interference approaches for treatment of HIV-1 infection. [PDF]
, 2015 HIV/AIDS is a chronic and debilitating disease that cannot be cured with current antiretroviral drugs. While combinatorial antiretroviral therapy (cART) can potently suppress HIV-1 replication and delay the onset of AIDS, viral mutagenesis often leads to
Bobbin, Maggie L +2 more
core +1 more source
Expression, Purification, and Analysis of Recombinant Drosophila Dicer-1 and Dicer-2 Enzymes [PDF]
, 2008 RNA interference (RNAi) is a form of posttranscriptional gene silencing mediated by microRNA (miRNA) and small interfering RNA (siRNA). In Drosophila melanogaster, the RNase III enzymes Dicer-1 and Dicer-2 generate miRNA and siRNA, respectively. We describe the methods for the expression, purification, and analysis of recombinant Dicer-1 and Dicer-2 ...
Xuecheng Ye, Qinghua Liu
openaire +3 more sources
Advanced Engineering Materials, EarlyView.This review explores wafer bonding technologies, covering wafer preparation, activation methods, and bonding mechanisms. It compares direct and indirect bonding, highlights recent advancements and future trends, and examines applications in 3D integration and packaging.
Abdul Ahad Khan +5 more
wiley +1 more source
FEBS Open Bio, 2020 MicroRNAs (miRNAs) are small noncoding RNA molecules that interact with target mRNAs at specific sites to induce cleavage of the mRNA or inhibit translation.
Akira Sato +8 more
doaj +1 more source
Global discovery and characterization of small non-coding RNAs in marine microalgae [PDF]
, 2014 Background Marine phytoplankton are responsible for 50% of the CO2 that is fixed annually worldwide and contribute massively to other biogeochemical cycles in the oceans. Diatoms and coccolithophores play a significant role as the base of the marine food
Beckers, Matthew +8 more
core +4 more sources
Distinct Roles for Drosophila Dicer-1 and Dicer-2 in the siRNA/miRNA Silencing Pathways [PDF]
Cell, 2004 The RNase III enzyme Dicer processes RNA into siRNAs and miRNAs, which direct a RNA-induced silencing complex (RISC) to cleave mRNA or block its translation (RNAi). We have characterized mutations in the Drosophila dicer-1 and dicer-2 genes. Mutation in dicer-1 blocks processing of miRNA precursors, whereas dicer-2 mutants are defective for processing ...
Young Sik Lee +6 more
openaire +3 more sources
Advanced Functional Materials, EarlyView.This study presents a capacitive hydrogen sensor with a simple structure and process. Sonication‐induced Pd nanogaps modulate the effective electrode area in response to hydrogen concentration, resulting in capacitance changes within a range predefined by physical parameters.
Sang‐kil Lee +9 more
wiley +1 more source
Mammalian Dicer finds a partner [PDF]
EMBO reports, 2005 RNA interference (RNAi) is a complex process that uses small RNAs of 21–23 nucleotides to guide sequence‐specific silencing of genetic information at both the transcriptional and post‐transcriptional levels. There are two main post‐transcriptional gene‐silencing pathways in metazoans: the microRNA (miRNA)‐mediated inhibition of translation and the ...
openaire +3 more sources
Advanced Functional Materials, EarlyView.Many known diseases arise from dysregulated gene expression, and differentially expressed genes can serve as biomarkers to distinguish diseased cells from healthy tissues. In this study, reconfigurable nucleic acid nanoparticles (recNANPs) are introduced that can detect overexpressed cancer biomarkers and subsequently release RNAi inducers to silence ...
Yelixza I. Avila +7 more
wiley +1 more source
Cause or Effect: Misregulation of MicroRNA Pathways in Neurodegeneration
Frontiers in Neuroscience, 2012 During normal aging or neurodegenerative diseases, neuronal survival and function depend on protein homeostasis, which is regulated by multiple mechanisms, including the microRNA (miRNA) pathway.
Fen-Biao eGao, Eduardo eGascon
doaj +1 more source