Results 1 to 10 of about 38,088 (249)

Dictyostelium discoideum as a non‐mammalian biomedical model

Microbial Biotechnology, 2021
Summary Dictyostelium discoideum is one of eight non‐mammalian model organisms recognized by the National Institute of Health for the study of human pathology. The use of this slime mould is possible owing to similarities in cell structure, behaviour and
Javier Martín‐González, Javier‐Fernando Montero‐Bullón, Jesus Lacal   +2 more
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Cell biology of Dictyostelium [PDF]

BMC Molecular and Cell Biology
The Cell Biology of Dictyostelium article collection highlights the benefits of using Dictyostelium as a model system for studying fundamental cellular processes.
Robert J. Huber, Paul A. Steimle, Cynthia K. Damer   +2 more
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Extracellular adenosine deamination primes tip organizer development in Dictyostelium [PDF]

eLife
Ammonia is a morphogen in Dictyostelium and is known to arise from the catabolism of proteins and RNA. However, we show that extracellular adenosine deamination catalysed by ‘adenosine deaminase-related growth factor’ (ADGF) is a major source of ammonia ...
Pavani Hathi, Baskar Ramamurthy
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Loss of Cln3 function in the social amoeba Dictyostelium discoideum causes pleiotropic effects that are rescued by human CLN3.

PLoS ONE, 2014
The neuronal ceroid lipofuscinoses (NCL) are a group of inherited, severe neurodegenerative disorders also known as Batten disease. Juvenile NCL (JNCL) is caused by recessive loss-of-function mutations in CLN3, which encodes a transmembrane protein that ...
Robert J Huber, Michael A Myre, Susan L Cotman   +2 more
doaj   +2 more sources

The use of streptavidin conjugates as immunoblot loading controls and mitochondrial markers for use with Dictyostelium discoideum

BioTechniques, 2013
The loading controls used for quantitative immunoblotting of mammalian proteins are not appropriate for use with Dictyostelium discoideum. Actin levels, for example, change greatly during Dictyostelium development.
Andrew J. Davidson, Jason S. King, Robert H. Insall   +2 more
doaj   +2 more sources

Acute stress and multicellular development alter the solubility of the Dictyostelium Sup35 ortholog ERF3 [PDF]

Microbiology Spectrum
Among sequenced organisms, the genome of Dictyostelium discoideum is unique in that it encodes for a massive amount of repeat-rich sequences in the coding region of genes.
Felicia N. Williams, Kanesha L. Travis, Holly N. Haver, Anna D. Umano, Yaneli Guerra-Hernandez, K. Matthew Scaglione   +5 more
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Iron metabolism and resistance to infection by invasive bacteria in the social amoeba Dictyostelium discoideum

Frontiers in Cellular and Infection Microbiology, 2013
Dictyostelium cells are forest soil amoebae, which feed on bacteria and proliferate as solitary cells until bacteria are consumed. Starvation triggers a change in life style, forcing cells to gather into aggregates to form multicellular organisms ...
Salvatore eBozzaro, Simona eBuracco, Barbara ePeracino   +2 more
doaj   +2 more sources

Identification and phylogenetic analysis of Dictyostelium discoideum kinesin proteins

BMC Genomics, 2003
Background Kinesins constitute a large superfamily of motor proteins in eukaryotic cells. They perform diverse tasks such as vesicle and organelle transport and chromosomal segregation in a microtubule- and ATP-dependent manner.
Glöckner Gernot, Kollmar Martin
doaj   +2 more sources

Diverse Roles of the Multiple Phosphodiesterases in the Regulation of Cyclic Nucleotide Signaling in Dictyostelium [PDF]

Cells
Dictyostelium is a unique model used to study the complex and interactive cyclic nucleotide signaling pathways that regulate multicellular development.
Pundrik Jaiswal, Alan R. Kimmel
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Opposite functions of RapA and RapC in cell adhesion and migration in Dictyostelium

Animal Cells and Systems, 2021
There are three Rap proteins in Dictyostelium. RapA is a key regulator of cell adhesion and cytoskeletal rearrangement. Recently, RapC has been reported to be involved in cytokinesis, cell migration, and multicellular development.
Jihyeon Jeon, Dongju Kim, Taeck Joong Jeon   +2 more
doaj   +1 more source