Results 101 to 110 of about 28,160 (153)
Abstract Phenylalanine ammonia lyase (PAL) enzymes have been extensively exploited to produce differently substituted arylalanine analogues, but their use in the stereoselective synthesis of aliphatic fatty amino acids has never been addressed. In this work, a two‐step hydroamination‐hydrodesulfurisation process has been investigated for the production
Celeste Nobbio+5 more
wiley +1 more source
GenePath: a System for Automated Construction of Genetic Networks from Mutant Data [PDF]
Motivation: Genetic pathways are often used in the analysis of biological phenomena. In classical genetics, they are constructed manually from experimental data on mutants. The field lacks formalism to guide such analysis, and accounting for all the data
Bratko, Ivan+6 more
core +1 more source
Background Development of the post-genomic age in Dictyostelium will require the existence of rapid and reliable methods to disrupt genes that would allow the analysis of entire gene families and perhaps the possibility to undertake the complete knock ...
Escalante Ricardo+2 more
doaj +1 more source
Developmental decisions in Dictyostelium discoideum
Dictyostelium discoideum is an excellent system in which to study developmental decisions. Synchronous development is triggered by starvation and rapidly generates a limited number of cell types. Genetic and image analyses have revealed the elegant intricacies associated with this simple development system.
Strmecki, L, Greene, D, Pears, C
openaire +4 more sources
Meeting report about self‐organization in biology: Freiburg Spemann–Mangold Centennial Symposium
In celebration of the centennial of the discovery of the gastrula organizer by Hans Spemann and Hilde Mangold, an international symposium titled Self‐Organization in Biology was held at the University of Freiburg from September 16 to 19, 2024. The symposium focused on developmental biology topics from in vivo embryonic studies to recent advancements in
Satoshi Kuwana, Yuuri Yasuoka
wiley +1 more source
Organisms like Dictyostelium discoideum, often referred to as DNA damage "extremophiles", can survive exposure to extremely high doses of radiation and DNA crosslinking agents. These agents form highly toxic DNA crosslinks that cause extensive DNA damage.
Xiao-Yin Zhang+5 more
doaj +1 more source
Dictyostelium development: Lower STATs [PDF]
The discovery of a STAT protein in Dictyostelium indicates that this organism uses phosphotyrosine-SH2-domain signalling during development. Such signalling is lacking in yeast and its appearance may therefore be an early step in the evolution of multicellularity.
openaire +3 more sources
Biochemical and Structural Characterisation of a Bacterial Lactoperoxidase
This study presents the biochemical and structural characterization of CyanoPOX, a heme‐containing peroxidase from Cyanobacterium sp. TDX16. Expressed in E. coli, the enzyme exhibits properties similar to bovine lactoperoxidase despite low sequence identity.
Ognjen Pećanac+5 more
wiley +1 more source
Web-enabled knowledge-based analysis of genetic data [PDF]
We present a web-based implementation of GenePath, an intelligent assistant tool for data analysis in functional genomics. GenePath considers mutant data and uses expert-defined patterns to find gene-to-gene or gene-to-outcome relations.
Bratko, Ivan+6 more
core +2 more sources