Results 121 to 130 of about 47,596 (285)

β‐Catenin localization in the ctenophore Mnemiopsis leidyi suggests an ancestral role in cell adhesion and nuclear function

Developmental Dynamics, Volume 254, Issue 9, Page 1055-1067, September 2025.
Abstract Background The emergence of multicellularity in animals marks a pivotal evolutionary event, which was likely enabled by molecular innovations in the way cells adhere and communicate with one another. β‐Catenin is significant to this transition due to its dual role as both a structural component in the cadherin–catenin complex and as a ...
Brian M. Walters, Lucas J. Guttieres, Mayline Goëb, Stanley J. Marjenberg, Mark Q. Martindale, Athula H. Wikramanayake   +5 more
wiley   +1 more source

Multiscale modeling of oscillations and spiral waves in Dictyostelium populations

, 2014
Unicellular organisms exhibit elaborate collective behaviors in response to environmental cues. These behaviors are controlled by complex biochemical networks within individual cells and coordinated through cell-to-cell communication.
Gregor, Thomas, Mehta, Pankaj, Noorbakhsh, Javad, Schwab, David, Sgro, Allyson   +4 more
core   +1 more source

A gradient method for the quantitative analysis of cell movement and tissue flow and its application to the analysis of multicellular Dictyostelium development [PDF]

, 1994
We describe the application of a novel image processing method, which allows quantitative analysis of cell and tissue movement in a series of digitized video images. The result is a vector velocity field showing average direction and velocity of movement
Miike, Hidetoshi, Nomura, Atsushi, Siegert, Florian, Weijer, Cornelis J.   +3 more
core   +1 more source

A signal transduction blind spot: the function of adenylyl cyclase transmembrane domains

The FEBS Journal, Volume 292, Issue 17, Page 4477-4486, September 2025.
Transmembrane adenylyl cyclases (tmACs) are essential for synthesising the universal second messenger cyclic AMP. All tmACs share a common topology that includes a large 12‐helix transmembrane (TM) domain. This domain accounts for ~ 35% of the coding sequence but its function is still an open question.
Ryan S. Dowsell, Matthew G. Gold
wiley   +1 more source

Modelling cell movement, cell differentiation, cell sorting and proportion regulation in Dictyostelium discoideum aggregations [PDF]

, 2015
Understanding the mechanisms that control tissue morphogenesis and homeostasis is a central goal not only in developmental biology but also has great relevance for our understanding of various diseases, including cancer.
Berks, Bonner, Bretschneider, Bretschneider, Brookman, C.J. Weijer, Dormann, Eftimie, Fisher, Gross, Hillen, Hoefer, Inouye, Kay, Kay, Kay, Kay, M. Pineda, Martiel, Maruo, Marée, Marée, Mizuguchi, Nakajima, Nanjundiah, Palsson, Palsson, Pate, R. Eftimie, Raper, Rietdorf, Rieu, Ràfols, Sakai, Saran, Savill, Schaap, Siegert, Siegert, Soll, Tyson, Uchinomia, van Oss, Vasiev, Weijer, Weijer   +45 more
core   +3 more sources

Assets of the non-pathogenic microorganism Dictyostelium discoideum as a model for the study of eukaryotic extracellular vesicles [v1; ref status: indexed, http://f1000r.es/pa]

F1000Research, 2013
Dictyostelium discoideum microvesicles have recently been presented as a valuable model for eukaryotic extracellular vesicles. Here, the advantages of D.
Irène Tatischeff
doaj   +1 more source

Developmental decisions in Dictyostelium discoideum

Developmental Biology, 2005
Dictyostelium discoideum is an excellent system in which to study developmental decisions. Synchronous development is triggered by starvation and rapidly generates a limited number of cell types. Genetic and image analyses have revealed the elegant intricacies associated with this simple development system.
Strmecki, L, Greene, D, Pears, C
openaire   +3 more sources

Re‐evaluation of PTEN as an ADP‐ribosylated tankyrase binding partner

The FEBS Journal, Volume 292, Issue 17, Page 4611-4630, September 2025.
We reveal that PTEN and its conserved putative tankyrase‐binding motif (pTBM) originated before tankyrases in evolution. We demonstrate that the pTBM shows no binding to tankyrase ARC domains, but it has structural and functional roles. We show, using recombinant proteins, that PTEN is not a tankyrase binding partner and substrate, and that catalytic ...
Chiara Bosetti, Albert Galera‐Prat, Anette Schmidt, Johan Pääkkönen, Aki Manninen, Lari Lehtiö   +5 more
wiley   +1 more source

Iron metabolism and resistance to infection by invasive bacteria in the social amoeba Dictyostelium discoideum

Frontiers in Cellular and Infection Microbiology, 2013
Dictyostelium cells are forest soil amoebae, which feed on bacteria and proliferate as solitary cells until bacteria are consumed. Starvation triggers a change in life style, forcing cells to gather into aggregates to form multicellular organisms capable
S. Bozzaro, Simona Buracco, B. Peracino
semanticscholar   +1 more source

ABC Transporters in Dictyostelium discoideum Development

PLoS ONE, 2013
ATP-binding cassette (ABC) transporters can translocate a broad spectrum of molecules across the cell membrane including physiological cargo and toxins. ABC transporters are known for the role they play in resistance towards anticancer agents in chemotherapy of cancer patients.
Miranda, Edward Roshan, Zhuchenko, Olga, Toplak, Marko, Santhanam, Balaji, Zupan, Blaz, Kuspa, Adam, Shaulsky, Gad   +6 more
openaire   +6 more sources