Results 11 to 20 of about 46,917 (300)

An ancestral non-proteolytic role for presenilin proteins in multicellular development of the social amoeba dictyostelium discoideum [PDF]

Journal of Cell Science, 2014
Mutations in either of two presenilin genes can cause familial Alzheimer's disease. Presenilins have both proteolysis-dependent functions, as components of the γ-secretase complex, and proteolysis-independent functions in signalling.
Ahn, Allan, Berridge, Boeckeler, Calahorro, Chang, Chávez-Gutiérrez, Coen, De Strooper, De Strooper, De Strooper, Donoviel, Edbauer, Eichinger, Faix, Feng, Fluhrer, Francione, Garcia, Haass, Harwood, Herreman, Hooper, Huppert, Janetopoulos, Kang, Kang, Khandelwal, Kim, Kumar, Li, Livak, Loomis, Ludtmann, McMains, Myre, Müller, Müller-Taubenberger, Parks, Rambaut, Rambaut, Ronquist, Rozen, Saxe, Schaeffer, Shen, Terbach, Tesco, Tu, Twomey, van Tijn, Veltman, Veltman, Walter, Wang, Williams, Williams, Williams, Wolfe, Yamasaki   +59 more
core   +5 more sources

Analysis of Dictyostelium discoideum Inositol Pyrophosphate Metabolism by Gel Electrophoresis

PLoS ONE, 2014
The social amoeba Dictyostelium discoideum was instrumental in the discovery and early characterization of inositol pyrophosphates, a class of molecules possessing highly-energetic pyrophosphate bonds.
Giuseppina Rose, Marco Gaspari, Adolfo Saiardi   +2 more
exaly   +2 more sources

Ion Signaling in Cell Motility and Development in Dictyostelium discoideum [PDF]

Biomolecules
Cell-to-cell communication is fundamental to the organization and functionality of multicellular organisms. Intercellular signals orchestrate a variety of cellular responses, including gene expression and protein function changes, and contribute to the ...
Yusuke V. Morimoto
doaj   +2 more sources

The genome of the social amoeba Dictyostelium discoideum

Nature, 2005
Matthew Berriman, Ian Goodhead, Donna M Muzny   +2 more
exaly   +2 more sources

Dictyostelium discoideum

Methods in Molecular Biology
Charrat, Bastien, Durrmeyer, Martin, Jaouad, Wajdi, Lejolivet, Solène, Rodriguez, Ugo, Latifi, Amel   +5 more
openaire   +3 more sources

Insights on Microsatellite Characteristics, Evolution, and Function From the Social Amoeba Dictyostelium discoideum

Frontiers in Neuroscience, 2022
Microsatellites are repetitive sequences commonly found in the genomes of higher organisms. These repetitive sequences are prone to expansion or contraction, and when microsatellite expansion occurs in the regulatory or coding regions of genes this can ...
Felicia N. Williams, K. Matthew Scaglione, K. Matthew Scaglione, K. Matthew Scaglione   +3 more
doaj   +1 more source

A recombinant antibody toolbox for Dictyostelium discoideum

BMC Research Notes, 2020
Objective The amoeba Dictyostelium discoideum has been a valuable model organism to study numerous facets of eukaryotic cell biology, such as cell motility, cell adhesion, macropinocytosis and phagocytosis, host–pathogen interactions and multicellular ...
Wanessa C. Lima, Philippe Hammel, Pierre Cosson   +2 more
doaj   +1 more source

BTG interacts with retinoblastoma to control cell fate in Dictyostelium. [PDF]

, 2010
In the genesis of many tissues, a phase of cell proliferation is followed by cell cycle exit and terminal differentiation. The latter two processes overlap: genes involved in the cessation of growth may also be important in triggering differentiation ...
Ceccarelli, Adriano, Conte, Daniele, MacWilliams, Harry K.   +2 more
core   +9 more sources

A RabGAP regulates life-cycle duration via trimeric G-protein cascades in Dictyostelium discoideum. [PDF]

PLoS ONE, 2013
BACKGROUND: The life-cycle of cellular slime molds comprises chronobiologically regulated processes. During the growth phase, the amoeboid cells proliferate at a definite rate.
Hidekazu Kuwayama, Yukihiro Miyanaga, Hideko Urushihara, Masahiro Ueda   +3 more
doaj   +1 more source

Low Base-Substitution Mutation Rate but High Rate of Slippage Mutations in the Sequence Repeat-Rich Genome of Dictyostelium discoideum

G3: Genes, Genomes, Genetics, 2020
We describe the rate and spectrum of spontaneous mutations for the social amoeba Dictyostelium discoideum, a key model organism in molecular, cellular, evolutionary and developmental biology. Whole-genome sequencing of 37 mutation accumulation lines of D.
Sibel Kucukyildirim, Megan Behringer, Way Sung, Debra A. Brock, Thomas G. Doak, Hatice Mergen, David C. Queller, Joan E. Strassmann, Michael Lynch   +8 more
doaj   +1 more source