Results 81 to 90 of about 47,596 (285)
Dictyostelium: An Important Source of Structural and Functional Diversity in Drug Discovery
Cells, 2018 The cellular slime mold Dictyostelium discoideum is an excellent model organism for the study of cell and developmental biology because of its simple life cycle and ease of use.
Yuzuru Kubohara, Haruhisa Kikuchi
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Cells, 2021 The social amoeba Dictyostelium discoideum provides an excellent model for research across a broad range of disciplines within biology. The organism diverged from the plant, yeast, fungi and animal kingdoms around 1 billion years ago but retains common ...
Robin S. B. Williams +6 more
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Highlights of the FEBS3+ meeting Exploring molecular frontiers
FEBS Open Bio, Volume 16, Issue 2, Page 240-242, February 2026.FEBS+ meeting Exploring molecular frontiers, held in Pula, Croatia, in autumn 2024 was jointly organized by the Croatian, Finnish, and Swedish Member Societies of the Federation of European Biochemical Societies (FEBS). The congress covered a wide variety of different biochemical themes, some of the highlights of which are presented in this ‘In the ...
Morana Dulić +2 more
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Data on the expression and purification of Sestrin protein from Dictyostelium discoideum
Data in Brief, 2019 The data present here is related to the research article entitled “Sestrin-like protein from Dictyostelium discoideum is involved in autophagy under starvation stress” [1].
S. Rafia, S. Saran
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Protein tandem repeats that produce frameshifts can generate new structural states and functions
The FEBS Journal, Volume 293, Issue 3, Page 842-858, February 2026.We explored an alternative protein structure landscape by analyzing amino acid sequences from frameshifted tandem repeats—regions prone to frameshifts. These frameshifts, especially in short repeats, lead to more drastic changes than in non‐repetitive regions, often altering structure, function, localization, and potentially contributing to disease ...
Zarifa Osmanli +8 more
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PTEN redundancy: overexpressing lpten, a homolog of Dictyostelium discoideum ptenA, the ortholog of human PTEN, rescues all behavioral defects of the mutant ptenA-. [PDF]
PLoS ONE, 2014 Mutations in the tumor suppressor gene PTEN are associated with a significant proportion of human cancers. Because the human genome also contains several homologs of PTEN, we considered the hypothesis that if a homolog, functionally redundant with PTEN ...
Daniel F Lusche +7 more
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The Social Amoeba Dictyostelium discoideum Is Highly Resistant to Polyglutamine Aggregation*
Journal of Biological Chemistry, 2015 Background: The Dictyostelium proteome is predicted to encode a vast amount of homopolymeric amino acid tracts, including long polyglutamine tracts. Results: Proteins with long polyglutamine tracts are soluble in Dictyostelium.
Stephanie Santarriaga +6 more
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Production of antibacterial compounds by a Steely hybrid polyketide synthase in Dictyostelium
FEBS Open Bio, Volume 16, Issue 1, Page 68-78, January 2026.By selecting appropriate production species under optimised culture conditions, new chlorinated dibenzofuran compounds, which previously could not be analysed in sufficient quantities, were identified from cellular slime mould fruiting bodies. The strong antibacterial activity exhibited by these compounds suggests a link to the ecological function of ...
Tomoaki R. Yamashita +3 more
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Genomic database resources for Dictyostelium discoideum [PDF]
Nucleic Acids Research, 2002 Dictyostelium is an attractive model system for the study of mechanisms basic to cellular function or complex multicellular developmental processes. Recent advances in Dictyostelium genomics have generated a wide spectrum of resources. However, much of the current genomic sequence information is still not currently available through GenBank or related ...
Lisa, Kreppel, Alan R, Kimmel
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Aggregate, Volume 7, Issue 1, January 2026.We developed a general tissue‐extraction strategy that directly purifies native F‐actin and actin–tropomyosin–myosin (ATM) complexes from human and rodent muscles for cryo‐EM. Near‐atomic structures, including an HCM R404Q mouse model, reveal how a disease myosin mutation remodels ATM assembly and alters myosin conformation at the actin interface ...
Danni Li +15 more
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