Results 81 to 90 of about 46,898 (283)

The Social Amoeba Dictyostelium discoideum Is Highly Resistant to Polyglutamine Aggregation*

Journal of Biological Chemistry, 2015
Background: The Dictyostelium proteome is predicted to encode a vast amount of homopolymeric amino acid tracts, including long polyglutamine tracts. Results: Proteins with long polyglutamine tracts are soluble in Dictyostelium.
Stephanie Santarriaga, A. Petersen, K. Ndukwe, A. Brandt, N. Gerges, Jamie Bruns Scaglione, K. Scaglione   +6 more
semanticscholar   +1 more source

Expanding the Inositol Pyrophosphate Toolbox: Stereoselective Synthesis and Application of PP‐InsP4 Isomers in Plant Signaling

Angewandte Chemie International Edition, Volume 64, Issue 36, September 1, 2025.
Stereochemically defined inositol pyrophosphate isomers (PP‐InsP4) were synthesized and assigned by NMR spectroscopy using a chiral solvating agent. In the form of isotopically labeled standards, they were applied in CE‐MS‐based profiling of plant extracts and kinase assays, enabling structural reassignment and functional insight into enzymatic ...
Kevin Ritter, Anne‐Sophie C. Braun, Guizhen Liu, Mengsi Lu, Verena Gaugler, Gabriel Schaaf, Henning Jacob Jessen   +6 more
wiley   +1 more source

Motility mutants of Dictyostelium discoideum. [PDF]

The Journal of cell biology, 1982
We describe six motility mutants of Dictyostelium discoideum in this report. They were identified among a group of temperature-sensitive growth (Tsg) mutants that had been previously isolated using an enrichment for phagocytosis-defective cells. The Tsg mutants were screened for their ability to produce tracks on gold-coated cover slips, and several ...
Martin Reichel, S C Kayman, M Clarke
openaire   +3 more sources

Loss of Cln3 Function in the Social Amoeba Dictyostelium discoideum Causes Pleiotropic Effects That Are Rescued by Human CLN3

PLoS ONE, 2014
The neuronal ceroid lipofuscinoses (NCL) are a group of inherited, severe neurodegenerative disorders also known as Batten disease. Juvenile NCL (JNCL) is caused by recessive loss-of-function mutations in CLN3, which encodes a transmembrane protein that ...
R. Huber, Michael A. Myre, S. Cotman
semanticscholar   +1 more source

β‐Catenin localization in the ctenophore Mnemiopsis leidyi suggests an ancestral role in cell adhesion and nuclear function

Developmental Dynamics, Volume 254, Issue 9, Page 1055-1067, September 2025.
Abstract Background The emergence of multicellularity in animals marks a pivotal evolutionary event, which was likely enabled by molecular innovations in the way cells adhere and communicate with one another. β‐Catenin is significant to this transition due to its dual role as both a structural component in the cadherin–catenin complex and as a ...
Brian M. Walters, Lucas J. Guttieres, Mayline Goëb, Stanley J. Marjenberg, Mark Q. Martindale, Athula H. Wikramanayake   +5 more
wiley   +1 more source

Thermotaxis by pseudoplasmodia of Dictyostelium discoideum. [PDF]

Proceedings of the National Academy of Sciences, 1977
The temperature dependence of migration rate and of the thermotactic sensitivity of pseudoplasmodia of Dictyostelium discoideum has been measured. Migration rate increases with temperature to 20 degrees, is temperature insensitive from 20 degrees to 27.5 degrees, and decreases with temperature to 29 degrees, above which point migration ceases. However,
Kenneth L. Poff, Michiyo Skokut
openaire   +3 more sources

PTEN redundancy: overexpressing lpten, a homolog of Dictyostelium discoideum ptenA, the ortholog of human PTEN, rescues all behavioral defects of the mutant ptenA-. [PDF]

PLoS ONE, 2014
Mutations in the tumor suppressor gene PTEN are associated with a significant proportion of human cancers. Because the human genome also contains several homologs of PTEN, we considered the hypothesis that if a homolog, functionally redundant with PTEN ...
Daniel F Lusche, Deborah Wessels, Nicole A Richardson, Kanoe B Russell, Brett M Hanson, Benjamin A Soll, Benjamin H Lin, David R Soll   +7 more
doaj   +1 more source

Analysis of Dictyostelium discoideum Inositol Pyrophosphate Metabolism by Gel Electrophoresis

PLoS ONE, 2014
The social amoeba Dictyostelium discoideum was instrumental in the discovery and early characterization of inositol pyrophosphates, a class of molecules possessing highly-energetic pyrophosphate bonds.
F. Pisani, T. Livermore, G. Rose, Jonathan R. Chubb, M. Gaspari, A. Saiardi   +5 more
semanticscholar   +1 more source

Localization of actin in Dictyostelium amebas by immunofluorescence [PDF]

, 1977
Antibody prepared against avian smooth muscle actin has been used to localize actin in the slime mold, Dictyostelium discoideum. The distribution of actin in migrating cells is different from that in feeding cells.
Eckert, Barry S., Lazarides, Elias
core   +2 more sources

A signal transduction blind spot: the function of adenylyl cyclase transmembrane domains

The FEBS Journal, Volume 292, Issue 17, Page 4477-4486, September 2025.
Transmembrane adenylyl cyclases (tmACs) are essential for synthesising the universal second messenger cyclic AMP. All tmACs share a common topology that includes a large 12‐helix transmembrane (TM) domain. This domain accounts for ~ 35% of the coding sequence but its function is still an open question.
Ryan S. Dowsell, Matthew G. Gold
wiley   +1 more source