Results 41 to 50 of about 2,521 (195)

Surgically confirmed severe endometriosis is associated with lower risk of steatotic liver disease: Evidence of estrogen‐linked hepatic–reproductive crosstalk

International Journal of Gynecology &Obstetrics, EarlyView.
Severe surgically confirmed endometriosis was associated with a lower prevalence of steatotic liver disease than non‐severe disease. Higher estradiol levels may partly explain this inverse hepatic–reproductive association, supporting integrated gynecologic and hepatologic risk assessment.
Jung Hyun Park, Keungmo Yang, Hyun Yang, Si Hyun Bae, Mee‐Ran Kim, Jaejun Lee   +5 more
wiley   +1 more source

Efficacy and Safety of Elagolix Versus Dienogest for Treatment of Moderate‐to‐Severe Endometriosis Pain: A Phase III, Multicentric, Double‐Blind, Active‐Controlled, Non‐Inferiority Study

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Objective To compare the efficacy, safety and tolerability of elagolix with dienogest in women with moderate‐to‐severe endometriosis‐associated pain. Design A multicentre, double‐blind, double‐dummy, randomised, parallel‐group, active‐controlled, non‐inferiority phase III study. Setting Nineteen clinical centres across India.
Sneha Bhoir, Jaldhara Patel, Tushar Palve, Mrinal Kanti Dash, Sweety Saigal, Gourisankar Kamilya, Shalini Srivastava, Kartikbhai Savalia, Tanusree Gupta, Deepa Choudhary, Manohar Rangaswamy, Vidya V Bhatt, Neena Gupta, Malathi Ponnuru, Parul Shah, Apurva Shetty, Shruti Saha, Reshma Quadros, Sucheta Pandit, Dipak Patil, Piyush Patel, Pravin Ghadge, Lalit Lakhwani, Suyog Mehta, Sadhana Joglekar   +24 more
wiley   +1 more source

Prescription trends for combined oral contraceptives and thromboembolism incidence in Japan before and after public awareness events in 2013–2015

International Journal of Gynecology &Obstetrics, Volume 174, Issue 1, Page 299-308, July 2026.
Abstract Objective Combined oral contraceptives (COCs) for dysmenorrhea management have been covered by the Japanese universal health insurance system since 2008. Several public awareness events regarding COC prescriptions for dysmenorrhea were implemented between 2013 and 2015, including media reports on COC‐related fatalities in 2013, drug safety ...
Risa Ishida, Yusuke Sasabuchi, Kaori Koga, Shiori Itoi, Gentaro Izumi, Daisuke Shigemi, Hiroki Matsui, Yutaka Osuga, Hideo Yasunaga   +8 more
wiley   +1 more source

Effect of Dienogest therapy on the size of the endometrioma

, 2020
Studies have been published on the efficacy of Dienogest in the management of pain symptoms in endometriosis. Nonetheless, few data are available on the reducing effect on endometrioma’s size.
Barbera V., Pietropaolo, Giuliana, Angioni, Stefano, Barbasetti Di Prun A., Belloni, Gaia Maria, Belloni G. M., Pino, Ida, Pino I., Barbasetti Di Prun, Allegra, Vignali, Michele, Vignali M., Pietropaolo G., Barbera, Valeria, Angioni S.   +13 more
core   +1 more source

Efficacy of 0.5 mg Dienogest Tablets in Treating Premenstrual Syndrome-like Symptoms: A Comparative Study with a Low-Dose Estrogen–Progestin Combination

Endocrines
Dysmenorrhea treatment with 0.5 mg dienogest tablets twice daily (1 mg/day) has proven useful, but its effect on premenstrual disorders has not yet been evaluated.
Haruko Yokosuka
doaj   +1 more source

Estetrol‐based combined oral contraceptives: A systematic review of clinical outcomes

Acta Obstetricia et Gynecologica Scandinavica, Volume 105, Issue 6, Page 983-998, June 2026.
This systematic review summarizes clinical outcomes of estetrol‐containing combined oral contraceptives, showing reliable contraceptive efficacy, predictable bleeding patterns, improved well‐being, and a favorable hemostatic and metabolic profile, suggesting a promising and potentially safer alternative to ethinylestradiol‐based formulations.
Mathilde Råberg, Ingeborg Rose Vad, Kara Hildur Axelsdóttir, Ellen Christine Leth Løkkegaard   +3 more
wiley   +1 more source

Impact of combined oral contraceptives and progestin‐only pills on psychological and sexual well‐being of women with endometriosis: A systematic review

Acta Obstetricia et Gynecologica Scandinavica, Volume 105, Issue 5, Page 805-818, May 2026.
Hormonal treatments for endometriosis (combined oral contraceptives/progestin‐only pills) do not show increased psychological or sexual risks compared with placebo. When pain is effectively controlled, these therapies appear well tolerated and may improve overall well‐being.
Noemi Salmeri, Martina Piccini, Francesca Caprara, Edgardo Somigliana, Paola Viganò, Paolo Vercellini   +5 more
wiley   +1 more source

Single‐Dose Bioequivalence Study of Elagolix Tablets 200 mg (Test Product) and Elagolix Tablets 200 mg (Reference Product) in Healthy Non‐Pregnant, Non‐Lactating Premenopausal Female Subjects Under Fasting Conditions

Clinical Pharmacology in Drug Development, Volume 15, Issue 4, April 2026.
Abstract Elagolix is a short‐acting oral gonadotropin‐releasing hormone antagonist utilized for treating endometriosis‐associated pain by rapidly suppressing gonadotropins and estradiol. Although well characterized in Western populations, clinical data regarding its use in Indian women remain limited.
Sudershan Kumar, Arshad Khuroo, Reshma Quadros, Shruti Dharmadhikari, Chintan Khandhedia, Gaurav Puppalwar, Amey Mane   +6 more
wiley   +1 more source

Endometriosis features and dienogest tolerability in women with depression: a case-control study [PDF]

, 2023
Objective Primary aim of this study was to investigate endometriosis characteristics of patients with psychiatric conditions or depression. The secondary aim was to study tolerability of dienogest in this context.
Knobel, Chiara, Merki-Feld, Gabriele S, Muendane, Anne, Portmann, Lea, Imesch, Patrick, Niggli, Angela, Neumeier, Maria S, Dietrich, Hanna, Metzler, Julian   +8 more
core   +1 more source

Drug therapy efficacy for the syndrome of chronic pelvic pain relapses in perinatal endometriosis

Кубанский научный медицинский вестник, 2015
Comparative analysis of drug therapy efficacy for the syndrome of chronic pelvic pain relapses in perinatal endometriosis has been presented: it included dienogest monotherapy and combined interleukin-2 (il-2) and dienogest therapy.
R. A. Musolyants, I. I. Kutsenko, E. I. Kravtsova, N. R. Danilova   +3 more
doaj