Results 101 to 110 of about 901,766 (310)

Liver Stiffness Directs Intrahepatic Cholesterol Accumulation Through YAP/TAZ in Metabolic Dysfunction‐Associated Steatotic Liver Disease

Advanced Science, EarlyView.
Liver stiffness promotes intrahepatic cholesterol accumulation by repressing LXRα through YAP/TAZ activation. Stiff matrices impair cholesterol efflux in hepatocytes, while YAP/TAZ deletion restores LXRα activity and prevents cholesterol‐induced fibrosis.
Na Young Lee, Myeung Gi Choi, Ho Jae Ryu, Young Jin Min, Seon Min Kim, Yeonseok Chung, Bo Kyung Koo, Yun Pyo Kang, Won Kim, Ja Hyun Koo   +9 more
wiley   +1 more source

Switching from a high-fat cellulose diet to a high-fat pectin diet reverses certain obesity-related morbidities

Nutrition & Metabolism, 2018
Background Reducing caloric intake is a proven intervention for mitigating and modulating morbidities associated with overnutrition. Caloric restriction is difficult to affect clinically, therefore, dietary interventions that ameliorate the adverse ...
Julie K. Bray, Gabriel S. Chiu, Leslie K. McNeil, Morgan L. Moon, Robyn Wall, Albert E. Towers, Gregory G. Freund   +6 more
doaj   +1 more source

Daily physical activity and macronutrient distribution of low-calorie diets jointly affect body fat reduction in obese women. [PDF]

, 2009
Inadequate dietary patterns and sedentary lifestyles are believed to be important factors in predisposing people to obesity. This study analyzed the potential interaction between habitual physical activity and the carbohydrate (CHO)-fat distribution in ...
Lopez-Fontana, C.M. (Constanza Matilde), Martinez, J.A. (José Alfredo), Martinez-Gonzalez, M.A. (Miguel Ángel), Sanchez-Villegas, A. (Almudena)   +3 more
core   +1 more source

Piezo2 Mediates a Vicious Cycle of “Mechanical Homeostasis Imbalance—Inflammation” in Sensory Nerves and the Cartilage Endplate

Advanced Science, EarlyView.
In a lumbar spine instability model, dorsal root ganglion cells mediate the perception of relevant mechanical stresses through Piezo2 and subsequently release CGRP. CGRP activates the NF‐κB signaling pathway in cartilage endplate cells through the receptor RAMP1.
Hanpeng Xu, Wen Geng, Zhi Du, Yifan Du, Di Wu, Bide Tong, Huaizhen Liang, Xingyu Zhou, Zixuan Ou, Junyu Wei, Kun Wang, Yu Song, Wenbin Hua, Yan Xu, Wencan Ke, Bingjin Wang, Cao Yang   +16 more
wiley   +1 more source

Effects of Continuous Exercise and Silymarin Supplementation on Tumor Necrosis Factor-alpha (TNF-a) and Liver Leptin in Male Wistar Rats with Fatty Liver Disease

مجله دانشگاه علوم پزشکی گرگان, 2023
Background and Objective: Leptin is associated with metabolic disorders and promotes the development of liver steatosis to steatohepatitis. It selectively increases the secretion of Tumor-necrosis factor-α (TNF-a) in response to saturated fatty acid. The
Minoo Dadban Shahamat, Asra Askari, Fatemeh Habibollahi   +2 more
doaj  

High Carbohydrate and High Fat Diets

Experimental Biology and Medicine, 1933
SummaryThe glucose tolerance was not significantly altered by a very high carbohydrate intake, over a period of 7 days. After 7 days on a high fat diet, the response to the glucose tolerance test was typical of diabetes mellitus; the tolerance fapidly returned to the usual type, after return to the balanced diet.
E. M. Greisheimer, E. Goldsworthy, G. Thomas   +2 more
openaire   +1 more source

Consumed by Abdominal Distention

Arthritis Care &Research, EarlyView.
Abimbola Fadairo‐Azinge, James Grenert, Brian Haas, Mary Margaretten   +3 more
wiley   +1 more source

Early Radiation Therapy Response Assessment Using Multi‐Scale Photoacoustic Imaging

Advanced Science, EarlyView.
Tomographic and mesoscopic photoacoustics capture intratumoural features of radioresistance and response. ABSTRACT There is a critical unmet clinical need to identify biomarkers that predict and detect radiation therapy (RT) response in cancer. Using the unique capabilities of multi‐scale photoacoustic imaging (PAI) to depict tumor oxygenation and ...
Thierry L. Lefebvre, Mariam‐Eleni Oraiopoulou, Ellie V. Bunce, Thomas R. Else, Lorna C. Wright, Monika A. Golinska, Lina Hacker, Cara Brodie, Steven Kupczak, Yi Cheng, Lisa Young, Paul W. Sweeney, Sarah E. Bohndiek   +12 more
wiley   +1 more source

Probiotics modify tight-junction proteins in an animal model of nonalcoholic fatty liver disease

Therapeutic Advances in Gastroenterology, 2016
Background: We have investigated the effects of a multispecies probiotic preparation containing a combination of probiotic bacterial genera that included Bifidobacteria, Lactobacilli and a Streptococcus in a mouse model of high-fat diet or obesity ...
David Briskey, Mandy Heritage, Lesley-Anne Jaskowski, Jonathan Peake, Glenda Gobe, V. Nathan Subramaniam, Darrell Crawford, Catherine Campbell, Luis Vitetta   +8 more
doaj   +1 more source

A Novel Function of Nonadecanoic Acid in Regulating Glucose Homeostasis

Advanced Science, EarlyView.
This study identifies the odd‐chain fatty acid C19:0 as an endogenous ligand of GPR120 that promotes glucose homeostasis via Gαq signaling. In obesity, elevated palmitic acid suppresses endogenous C19:0 production through a miRNA–PPARα–HACL1 pathway, offering a promising direction for understanding the role of OCFAs in human health.
Yanting Hou, Yinghua Ma, Qin Liu, Dingling Ma, Yuxin Tong, Lili Xu, Xiaolong Chu, Jingzhou Wang, Maodi Liang, Mengyuan Zhao, Huizi Zhang, Yurui Su, Jianxin Xie, Cuizhe Wang, Jun Zhang   +14 more
wiley   +1 more source