Results 41 to 50 of about 15,949,045 (258)

mTORC2 protects the heart from high-fat diet-induced cardiomyopathy through mitochondrial fission in Drosophila [PDF]

, 2022
High-fat diet (HFD)-induced obesity has become the major risk factor for the development of cardiovascular diseases, but the underlying mechanisms remain poorly understood.
Bai, Hua, Liu, Peiduo, Chang, Kai, Requejo, Guillermo   +3 more
core  

Data_Sheet_1_Alteration and the Function of Intestinal Microbiota in High-Fat-Diet- or Genetics-Induced Lipid Accumulation.docx

, 2021
Diet and host genetics influence the composition of intestinal microbiota, yet few studies have compared the function of intestinal microbiota in the diet- or genotype-induced lipid deposition, which limits our understanding of the role of intestinal ...
Fang Tan (353838), Liqiao Chen (322720), Zhen-Yu Du (350261), Mei-Ling Zhang (765444), Ling-Yu Li (4922107), Fang Qiao (805531), Hong-Bo Lv (11447980)   +6 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The effects of exercise modalities on adiposity in obese rats

Clinics, 2012
OBJECTIVE: The aim of the present study was to evaluate the effect of both swimming and resistance training on tumor necrosis factor-alpha and interleukin-10 expression, adipocyte area and lipid profiles in rats fed a high-fat diet.
Guilherme Fleury Fina Speretta, Marisa Cristina Rosante, Fernanda Oliveira Duarte, Richard Diego Leite, Anderson Diogo de Souza Lino, Rafael Arquias Andre, João Guilherme de Oliveira Silvestre, Heloisa Sobreiro Selistre de Araujo, Ana Claudia Garcia de Oliveira Duarte   +8 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Calorie restriction and endurance exercise share potent anti-inflammatory function in adipose tissues in ameliorating diet-induced obesity and insulin resistance in mice

Nutrition & Metabolism, 2010
Background Calorie restriction (CR) and endurance exercise are known to attenuate obesity and improve the metabolic syndrome. The aim of this study was to directly compare the effects of CR and endurance exercise in a mouse model of diet-induced obesity ...
Yan Zhen, Li Wenjun, Mao Ting, You Jia, Zhao Feng, Qi Qibin, Shao Mengle, Li Shoufeng, Huang Ping, Liu Yong   +9 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Associations between diet, physical activity and body fat distribution: a cross sectional study in an Indian population. [PDF]

, 2015
BACKGROUND: Obesity is a growing health problem in India and worldwide, due to changes in lifestyle. This study aimed to explore the independent associations between dietary and physical activity exposure variables and total body fat and distribution in ...
Krishna, K V Radha, Sullivan, Ruth, Krishna, KV Radha, Kuper, Hannah, Wells, Jonathan, Taylor, Amy E, Bowen, Liza, Ekelund, Ulf, Kulkarni, Bharati, Wells, Jonathan CK, Kinra, Sanjay, Ben-Shlomo, Yoav, Ebrahim, Shah, Radha Krishna, K. V., Taylor, Amy E.   +14 more
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Impact of maternal high‐fat diet on offspring gut microbiota during short‐term high‐fat diet exposure in mice

Physiological Reports
Alterations in the gut microbiome have been linked to obesity, with maternal high‐fat diet (HF) playing a role in shaping offspring microbiome composition.
Henry A. Paz, Lasya Buddha, Ying Zhong, James D. Sikes, Umesh D. Wankhade   +4 more
doaj   +1 more source