Results 81 to 90 of about 897,060 (311)

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Inverse association between dietary fiber intake and gallstone disease in U.S. adults: a cross-sectional study from the NHANES database

Frontiers in Nutrition
BackgroundThe cross-sectional association of dietary fiber intake with gallstone disease in United States adults remains to be comprehensively elucidated.MethodsWe used the National Health and Nutrition Examination Survey (NHANES) data from 2017–2023 ...
Dianbao Zuo, Dianbao Zuo, Ming Sang, Xiaodong Sun, Guoping Chen, Kangkang Ji, Kangkang Ji   +6 more
doaj   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Association of dietary live microbes and nondietary prebiotic/probiotic intake with metabolic syndrome in US adults: evidence from NHANES

Scientific Reports
Background: Metabolic syndrome (MetS) presents substantial health risks, and the supplementation of probiotics and prebiotics is regarded as a promising management approach.
Zhi Wang, Haokun Zhang, Zilong Shao
doaj   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Association between dietary iron intake and hyperuricemia in U.S. adults: a cross-sectional study

BMC Public Health
Background Elevating blood iron levels may increase the risk of hyperuricemia. However, the association between dietary iron intake and hyperuricemia remains unclear. This study examines the association between dietary iron and hyperuricemia. Methods The
Zhengting Liu, Xianchun Chen
doaj   +1 more source

Trends in diet structural composition and quality among adults in Beijing, China (2010–2022)

Frontiers in Nutrition
BackgroundUnbalanced dietary patterns are a major risk factor for chronic non-communicable diseases. Examining trends in population-level dietary structural composition and quality is essential for monitoring nutritional transitions, identifying key ...
Ningsu Chen, Liyu Huang, Kai Zhao, Yimei Sha, Mengnan Zhao, Yihong Yao, Yana Qi, Yan Zhang, Bo Yu, Hairong He, Jiajie Yu, Jiali Duan   +11 more
doaj   +1 more source

Ketogenic Diet as an Epigenetic Therapy in SETD1B‐Related Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Histone lysine methyltransferases such as SETD1B regulate chromatin structure and gene transcription. Ketone bodies, including butyrate, act as histone deacetylase inhibitors. We report a 4‐year‐old boy with SETD1B‐related absence epilepsy, refractory to conventional medications, who achieved sustained > 90% seizure reduction on the Modified ...
Erica Tsang, Brian S. Gloss, Jessica P. Hayes, Andrew J. A. Holland, Manoj P. Menezes, Joceline A. Branson, Shekeeb S. Mohammad, Jingya J. Yan, Shrujna Patel, Velda X. Han, Russell C. Dale   +10 more
wiley   +1 more source

The relationship between dietary phosphorus and peripheral neuropathy in the general population of the United States: A preliminary research.

PLoS ONE
BackgroundDietary phosphorus intake may serve as a potential predictor for peripheral neuropathy (PN). While past research has predominantly focused on the relationship between dietary phosphorus and bone health, relatively little is known about its role
Chunli Wu, Zhe Wu, Yanling Chen, Huirong Xu, Kejian Li   +4 more
doaj   +1 more source

Perception of Moderation in Dietary Behaviors [PDF]

, 2017
The objective of this study is to understand what the general population perceives as dietary moderation, in relation to recommendations. It is hypothesized that the majority of respondents’ perceptions of moderate intake will be over- or underestimated ...
Malquist, Alexis, Perimon, Lexi, Prince, Rebecca   +2 more
core   +1 more source