Results 91 to 100 of about 497,650 (279)

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Safe Learning of Quadrotor Dynamics Using Barrier Certificates

, 2017
To effectively control complex dynamical systems, accurate nonlinear models are typically needed. However, these models are not always known. In this paper, we present a data-driven approach based on Gaussian processes that learns models of quadrotors ...
Egerstedt, Magnus, Theodorou, Evangelos A., Wang, Li   +2 more
core   +1 more source

Differential flatness theory‐based approach to the control of gas‐turbine electric power generation units

IET Control Theory & Applications, 2020
A differential flatness theory-based control and state estimation method has been developed for electric power units that consist of synchronous generators connected to gas turbines.
G. Rigatos, N. Zervos, K. Busawon, P. Siano, M. Abbaszadeh   +4 more
semanticscholar   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

A Robust Differential Flatness-Based Tracking Control for the “MIMO DC/DC Boost Converter–Inverter–DC Motor” System: Experimental Results

IEEE Access, 2019
By designing a robust control, for the first time in literature, the tracking task associated with the MIMO DC/DC Boost converter–inverter–DC motor system is solved.
José Rafael García-Sánchez, Eduardo Hernández-Márquez, Jesús Ramírez-Morales, M. Marciano-Melchor, M. Marcelino-Aranda, H. Taud, R. Silva-Ortigoza   +6 more
semanticscholar   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Robust multilevel average controller for trajectory tracking in mobile robots powered by solar panels: Integrating actuators and power electronics stage

Results in Engineering
This paper addresses the challenge of bidirectional trajectory tracking, for the first time in the literature, in wheeled mobile robots (WMRs) powered by renewable energy by thoroughly considering all involved subsystems.
Erik Reyes-Reyes, Benjamin Natanael Santiago-Nogales, Josué Roberto Rodríguez-Cerón, Ramón Silva-Ortigoza, Alfredo Roldán-Caballero, José Rafael García-Sánchez, Magdalena Marciano-Melchor, Hind Taud, Salvador Tavera-Mosqueda   +8 more
doaj   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Derivative-Free Nonlinear Kalman Filtering for MIMO Dynamical Systems: Application to Multi-DOF Robotic Manipulators

International Journal of Advanced Robotic Systems, 2011
The paper proposes derivative-free nonlinear Kalman Filtering for MIMO nonlinear dynamical systems. The considered nonlinear filtering scheme which is based on differential flatness theory extends the class of systems to which Kalman Filtering can be ...
Gerasimos G. Rigatos
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source