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Mechanisms of Gonadal Differentiation
Science, 1981Sex differentiation is the result of the translation of genetic sex into gonadal sex. Without recognizable masculinizing signals the embryonic gonad will undergo ovarian differentiation. The main determinant of gonadal differentiation appears to be the presence or absence of a cell surface antigen, called H-Y antigen.
F P, Haseltine, S, Ohno
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The Physics Teacher, 2021
About 30 years ago I taught a series of summer enrichment programs for high school physics teachers, using funding from the Howard Hughes Medical Institutes. I deliberately chose teachers from smaller cities and towns who were unlikely to have contact with other physics teachers.
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About 30 years ago I taught a series of summer enrichment programs for high school physics teachers, using funding from the Howard Hughes Medical Institutes. I deliberately chose teachers from smaller cities and towns who were unlikely to have contact with other physics teachers.
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Mechanisms of Cortical Differentiation
2018During fetal and postnatal development, the human brain generates 160 billion neuronal and glial cells, each with precise cellular phenotypes. To effectively manage such a complicated task, intrinsic (e.g., transcription factors) and extrinsic (environmental signals) cues cooperate to regulate the decision by neural progenitors to continue to ...
Lata, Adnani +4 more
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Mechanisms Regulating Spermatogonial Differentiation
2016Mammalian spermatogenesis is a complex and highly ordered process by which male germ cells proceed through a series of differentiation steps to produce haploid flagellated spermatozoa. Underlying this process is a pool of adult stem cells, the spermatogonial stem cells (SSCs), which commence the spermatogenic lineage by undertaking a differentiation ...
Jennifer M, Mecklenburg +1 more
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Control mechanisms of testicular differentiation
Philosophical Transactions of the Royal Society of London. B, Biological Sciences, 1988In this paper the importance of unknown factors responsible for the initial differentiation of a gonadal primordium is stressed. The hypothesis that in the absence of testis determining genes (TDG) the indifferent gonad is programmed to become an ovary is considered further.
A, Jost, S, Magre
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Genetic mechanisms of sex differentiation
Current Opinion in Pediatrics, 1996Cloning of the SRY sex-determining locus on the Y chromosome has stimulated research on the genetic mechanisms of sex determination. It now appears that SRY is not the only gene required for testicular differentiation; X-linked and autosomal genes are also important.
N, Josso, R, Rey
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Cell differentiation by mechanical stress
The FASEB Journal, 2001ABSTRACT Growth factors, hormones, and other regulatory molecules are traditionally required in tissue engineering studies to direct the differentiation of progenitor cells along specific lineages. We demonstrate that mechanical stimulation in vitro , without ligament ...
Gregory H, Altman +8 more
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Transcriptional mechanisms of chondrocyte differentiation
Matrix Biology, 2000With the goal of identifying master transcription factors that control the genetic program of differentiation of mesenchymal cells into chondrocytes, we first delineated a 48-bp chondrocyte-specific enhancer element in the gene for proalpha1(II) collagen (Col2a1), an early and abundant marker of chondrocytes.
B, de Crombrugghe +5 more
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