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Molecular Mechanisms of Megakaryocyte Differentiation
Seminars in Thrombosis and Hemostasis, 2004Each bone marrow megakaryocyte (MK) releases thousands of platelets into the circulation, and the underlying molecular and cellular mechanisms recently have received intense scrutiny. Genetic studies are beginning to clarify the mechanisms by which transcription factors help distinguish MK progenitors from other blood cell lineages and subsequently ...
Harald, Schulze, Ramesh A, Shivdasani
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Molecular mechanisms of endothelial differentiation
Vascular Medicine, 2010The differentiation of embryonic stem cells along the endothelial cell lineage requires a tightly coordinated sequence of events that are regulated in both space and time. Although significant gaps remain in this process, major strides have been made over the past 10 years in identifying the growth factors, signal transduction pathways, and ...
Alex, Le Bras +2 more
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Differential measuring mechanisms
Measurement Techniques, 19621. We have demonstrated the measuring facilities provided by differential mechanisms, their structural and kinematic unity, and their degeneration into parallelogram devices which constitute a double tangential mechanism. 2. The reason for the elimination of the effect of the component's run-out on the measurement results in differential
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MOLECULAR MECHANISMS REGULATING CHONDROBLAST DIFFERENTIATION
The Journal of Bone and Joint Surgery-American Volume, 2003Formation of the cartilage template involves a multi-step process in which prechondrogenic mesenchymal cells form condensations prior to differentiating into matrix-producing chondroblasts. Retinoids, particularly retinoic acid, are among the numerous signaling molecules that have been implicated in this process.
Lisa M, Hoffman +2 more
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Molecular Mechanisms of Presynaptic Differentiation
Annual Review of Cell and Developmental Biology, 2008Information processing in the nervous system relies on properly localized and organized synaptic structures at the correct locations. The formation of synapses is a long and intricate process involving multiple interrelated steps. Decades of research have identified a large number of molecular components of the presynaptic compartment.
Yishi, Jin, Craig C, Garner
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Mechanism of Differential Epidural Block
Anesthesia & Analgesia, 1986Pain block in obstetric epidural anesthesia is usually accompanied by relatively persistent retention of motor power; however, the reason for this is not entirely clear. The differential effect has been ascribed to a relatively high resistance of large fibers to conduction block.
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Substratum Mechanics and Cell Differentiation
1994Publisher Summary This chapter focuses on the cytomechanics of the regulation of expression of the differentiated phenotype in retinal pigmented epithelial (RPE) cells and, subsequently, on the cytomechanics of the process by which RPE cells alter their identity to become other distinct cell types, also known as “cell type conversion” or “cellular ...
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1999
Neural crest cells do not self-differentiate. Instead they diversify into particular cell types following interactions with other cells, extracellular matrices, growth factors, and/or hormones. These differentiative signals may be encountered in the premigratory environment in the neural tube, while neural crest cells are migrating, or after they ...
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Neural crest cells do not self-differentiate. Instead they diversify into particular cell types following interactions with other cells, extracellular matrices, growth factors, and/or hormones. These differentiative signals may be encountered in the premigratory environment in the neural tube, while neural crest cells are migrating, or after they ...
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Molecular Mechanisms in Erythroid Differentiation
1976The most striking molecular event during erythroid differentiation is the accumulation of haemoglobin but this is only one of many overt changes which occur in the maturing erythroid cell. Other proteins accumulate progressively, notably carbonic anhydrase and catalase while yet others, particularly the enzymes of haem synthesis, such as ...
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Arc crustal differentiation mechanisms
Earth and Planetary Science Letters, 2014Abstract The detailed vertical compositional and thermal structure of the entire Kohistan arc section is constructed using ∼ 63 P / T constraints and 209 plutonic whole rock analyses. The aim is to better understand the nature of the chemical differentiation in the plutonic arc crust at different crustal levels.
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