Results 121 to 130 of about 6,190 (152)

Predicting Agitation Stability of Monoclonal Antibodies during Developability Assessment. [PDF]

Mol Pharm
Cohrs M, Pagureva N, Ozbulak U, De Neve W, Braeckmans K, De Smedt S, Tcholakova S, Vinarov Z, Svilenov HL.   +8 more
europepmc   +1 more source

Shared HLA-E and Mamu-E Peptide Repertoires With Subtle Peptide Binding Differences Revealed by Combined nDSF- and Fluorescence Polarisation-Based Methods. [PDF]

Eur J Immunol
Quastel MN, Ranawana SA, Peeters BWA, van Hateren A, McMichael AJ, Gillespie GM.   +5 more
europepmc   +1 more source

Correction to "Heat-treated egg allergens show lower basophil activation: A path toward safer oral immunotherapy". [PDF]

Pediatr Allergy Immunol
europepmc   +1 more source

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The Use of Differential Scanning Fluorimetry to Assess Strigolactone Receptor Function

Methods in Molecular Biology, 2021
Differential scanning fluorimetry (DSF) is a method used for assessing the interaction of ligands with proteins. In most cases binding of a ligand to proteins tends to increase the melting temperature (Tm) of the protein involved. However, in the case of strigolactone receptors (e.g., D14, AtD14, DAD2, RMS3) from plants, the Tm tends to be reduced in ...
Cyril Hamiaux, Kimberley Snowden, Bart Janssen   +2 more
exaly   +3 more sources

Differential Scanning Fluorimetry for Monitoring RNA Stability

ChemBioChem, 2015
Abstract Cellular RNA function is closely linked to RNA structure. It is therefore imperative to develop methods that report on structural stability of RNA and how it is modulated by binding of ions, other osmolytes, and RNA‐binding ligands.
Harald Schwalbe, Martin Hengesbach, Robert Silvers   +2 more
exaly   +3 more sources

Nano differential scanning fluorimetry for comparability studies of therapeutic proteins

Analytical Biochemistry, 2020
Differential scanning calorimetry (DSC) has been extensively used in the biopharmaceutical industry to characterize protein thermal stability and domain folding integrity. Recently, nano differential scanning fluorimetry (nanoDSF) has emerged as a powerful tool for thermal stability analysis and studies of protein domain unfolding.
Jie, Wen, Harrison, Lord, Nicholas, Knutson, Mats, Wikström   +3 more
openaire   +2 more sources

Nano-Differential Scanning Fluorimetry for Screening in Fragment-based Lead Discovery

Journal of Visualized Experiments, 2021
Thermal shift assays (TSAs) examine how the melting temperature (Tm) of a target protein changes in response to changes in its environment (e.g., buffer composition). The utility of TSA, and specifically of nano-Differential Scanning Fluorimetry (nano-DSF), has been established over the years, both for finding conditions that help stabilize a specific ...
Ahmad, Misbha Ud Din, Fish, Alexander, Molenaar, Jeroen, Sreeramulu, Sridhar, Richter, Christian, Altincekic, Nadide, Schwalbe, Harald, Wienk, Hans, Perrakis, Anastassis   +8 more
openaire   +2 more sources

Differential scanning fluorimetry illuminates silk feedstock stability and processability

Soft Matter, 2016
The ability to design and implement silk feedstock formulations for tailored spinning has so far eluded the bioengineers. Recently, the high throughput screening technique of differential scanning fluorimetry (DSF) demonstrated the link between the instability transition temperature (Ti) and the processability of the silk feedstock.
C, Dicko, N, Kasoju, N, Hawkins, F, Vollrath   +3 more
openaire   +2 more sources