Results 121 to 130 of about 4,395,934 (279)

Differentially methylated regions (DMRs) and methylation context statistics.

, 2016
Pink shade (a) shows one of the top 200 DMRs in a CpG context between clonal Populus trichocarpa (cv. Muhle Larson) leaf material derived from two different short rotation forestry sites (Anderlingen vs.
Svenja Mager (3592469), Brigitte Schönberger (3592472), Xiaochao Chen (129106), Uwe Ludewig (1151)   +3 more
core   +1 more source

CTCFL/BORIS Is a Methylation-Independent DNA-Binding Protein That Preferentially Binds to the Paternal H19 Differentially Methylated Region

Cancer Research, 2008
The CTCF paralog BORIS (brother of the regulator of imprinted sites) is an insulator DNA-binding protein thought to play a role in chromatin organization and gene expression.
P. Nguyen, H. Cui, K. Bisht, Lunching Sun, K. Patel, Richard S. Lee, H. Kugoh, M. Oshimura, A. Feinberg, D. Gius   +9 more
semanticscholar   +1 more source

MethyAnno: An Interpretable Automated Annotation Method Leveraging Multi‐Scale Information and Metric Learning Framework for scDNAm Data

Advanced Science, EarlyView.
MethyAnno enables robust and interpretable annotation of single‐cell DNA methylation data by integrating multi‐scale epigenetic information, bidirectional cross‐attention, and prototype‐based metric learning. The framework resolves rare and novel cell types across datasets while revealing cell‐type‐specific epigenetic signatures associated with disease
Yuhang Jia, Siyu Li, Songming Tang, Keju Gu, Shengquan Chen   +4 more
wiley   +1 more source

Differential Water Networks Guide Selectivity Optimization of a Cell Active BPTF Inhibitor in Neuroblastoma

Angewandte Chemie, EarlyView.
BZ2 is a second‐generation Bromodomain PHD finger Transcription Factor (BPTF) inhibitor with improved selectivity over Class I and Class IV BRD off‐targets identified in our previously reported inhibitor, BZ1. Structural analyses reveal that water network engagement is key to this selectivity.
Kesavan Babu, Chun‐Ju Tsou, Sourav Das, Liying Fan, Anasuya Pal, Molly Sneddon, Timothy R. Stachowski, Priyanka Samanta, Stanley Nithianantham, Caroline Buchholz, Shi Zhang, Xiang Fu, Rahul S. Kathayat, Wenwei Lin, Yongtao Li, Lei Yang, Taosheng Chen, Marcus Fischer, Anang A. Shelat, William C. K. Pomerantz   +19 more
wiley   +2 more sources

NSUN2‐Mediated m5C Modification of TGFB1 in Trophoblasts Remodels Macrophage Function to Prevent URSA

Advanced Science, EarlyView.
NSUN2 and m5C decline in URSA villous tissues. Trophoblast Nsun2 ablation disrupts macrophage‐mediated maternal‐fetal tolerance and triggers embryo resorption. Mechanistically, NSUN2‐YBX1 axis stabilizes m5C‐modified TGFB1 mRNA to maintain TGF‐β1 secretion and M2 polarization, and restoring this signaling rescues maternal‐fetal immune tolerance to ...
Xiaoxiao Zhu, Xinkui Liu, Xiaoyan Yu, Qiaoqiao Han, Feifei Shi, Weiwei Song, Lu Liu, Chu Chu, Chenyang Shen, Zhen Zhang, Xia Li   +10 more
wiley   +1 more source

mCSEA: Detecting subtle differentially methylated regions

, 2018
MotivationThe identification of differentially methylated regions (DMRs) among phenotypes is one of the main goals of epigenetic analysis. Although there are several methods developed to detect DMRs, most of them are focused on detecting relatively large
Jordi Martorell-Marugán, Pedro Carmona-Sáez, Víctor González-Rumayor   +2 more
core   +1 more source

A comprehensive long-read sequencing system to assess DNA methylation at differentially methylated regions and imprinting-disorder-related genes

Genome Medicine
Background Imprinted genes are expressed in a parental-origin–specific manner. The imprinted regions including imprinted genes have differentially methylated regions (DMRs) with different 5-methylcytosine (5mC) patterns for CpGs on each parental allele ...
Tatsuki Urakawa, Atsushi Hattori, Yasuko Ogiwara, Hayate Masubuchi, Mizuho Igarashi, Sayuri Nakamura, Kaori Hara-Isono, Keisuke Ishiwata, Hiroko Ogata-Kawata, Hiromi Kamura, Yoko Kuroki, Kazuhiko Nakabayashi, Maki Fukami, Masayo Kagami   +13 more
doaj   +1 more source

The promoters of OsGLP genes exhibited differentially methylated sites under drought and salt stress in rice cultivars

Euphytica, 2023
J. Anum, C. O'Shea, K. Skriver, Muhammad Saeed, M. Z. Hyder, Sumaira Farrakh, T. Yasmin   +6 more
semanticscholar   +1 more source

Mutant KRAS‐m6A Epitranscriptome Axis Promotes Colorectal Cancer and is a Therapeutic Target

Advanced Science, EarlyView.
Mutant KRAS‐m6A axis promotes colorectal cancer (CRC) progression. Mutant KRAS stabilizes METTL3, leading to increased m6A‐modified BCL9L mRNA and translation of BCL9L protein. BCL9L in turn mediates TGF‐β secretion to induce differentiation of Treg and an immunosuppressive microenvironment.
Danyu Chen, Pingmei Huang, Ruizhi Tao, Fenfen Ji, Qinyao Wei, Lok Hin Ko, Lianxin Zhou, Huarong Chen, Alvin Cheung, Wei Kang, Ko Fai To, Jun Yu, Chi Chun Wong   +12 more
wiley   +1 more source

Ingenuity pathway analysis of genes with differentially methylated promoter sites.

, 2018
(A) Genes with differentially methylated promoters map to four main networks. Genes shown in bold contain one or more differentially methylated promoters in patients with ALL. (B) Graphical depiction of the interactions of genes in network 1.
Melissa L. Bondy (94038), Teresa T. Yiu (5220722), Spiridon Tsavachidis (92824), Michael E. Scheurer (386051), Karen R. Rabin (4373881), Lanlan Shen (25638), Jeremy M. Schraw (5220719), Philip J. Lupo (276043), Rachel Rau (5220725)   +8 more
core   +1 more source