Results 71 to 80 of about 524,560 (351)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Role of diffusion weighted imaging in characteriza

The Egyptian Journal of Radiology and Nuclear Medicine, 2016
Purpose: The purpose of the study was to show the value of combination of conventional MRI with DWI to raise the sensitivity and specificity considering the differentiation between pancreatic benign and malignant lesions.
Eman Salah Mohammed Abdallah, Mohamed Ibrahim Mahmoud Ali, Maryse Yousef Awadallah, Hamed Samir Hamed El Ghawabi   +3 more
doaj   +1 more source

Diffusion-Weighted Imaging Outside the Brain: Consensus Statement From an ISMRM-Sponsored Workshop

Journal of Magnetic Resonance Imaging, 2016
The significant advances in magnetic resonance imaging (MRI) hardware and software, sequence design, and postprocessing methods have made diffusion‐weighted imaging (DWI) an important part of body MRI protocols and have fueled extensive research on ...
B. Taouli, Ambros J. Beer, T. Chenevert, D. Collins, C. Lehman, C. Matos, Anwar R. Padhani, A. Rosenkrantz, A. Shukla-Dave, E. Sigmund, L. Tanenbaum, H. Thoeny, I. Thomassin-Naggara, S. Barbieri, I. Corcuera‐Solano, M. Orton, S. Partridge, D. Koh   +17 more
semanticscholar   +1 more source

Stroke penumbra defined by an MRI-based oxygen challenge technique: 1. validation using [14C]2-deoxyglucose autoradiography [PDF]

, 2011
Accurate identification of ischemic penumbra will improve stroke patient selection for reperfusion therapies and clinical trials. Current magnetic resonance imaging (MRI) techniques have limitations and lack validation.
Robertson, Craig A, Robertson, Craig A., William M Holmes, Celestine Santosh, Macrae, I Mhairi, McCabe, Chris, Maria del Rosario Lopez-Gonzalez, Lopez-Gonzalez, Maria del., Barrie Condon, Keith W Muir, Lindsay Gallagher, Holmes, William M., Christopher McCabe, Santosh, Celestine, Craig A Robertson, Lopez-Gonzalez, Maria del Rosario, Holmes, William M, Macrae, I. Mhairi, I Mhairi Macrae, Gallagher, Lindsay, Muir, Keith W, Condon, Barrie, McCabe, Christopher, Muir, Keith W.   +23 more
core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Diffusion-weighted imaging and diffusion-weighted whole-body imaging with background body signal suppression for characterizing esophageal cancer: a case report

International Medical Case Reports Journal, 2013
Minoru Tomizawa,1 Fuminobu Shinozaki,2 Aika Ozaki,2 Akira Baba,2 Yoshiya Fukamizu,2 Futoshi Matsunaga,2 Takao Sugiyama,3 Shigenori Yamamoto,4 Makoto Sueishi,3 Takanobu Yoshida51Department of Gastroenterology, 2Department of Radiology, 3Department of ...
Tomizawa M, Shinozaki F, Ozaki A, Baba A, Fukamizu Y, Matsunaga F, Sugiyama T, Yamamoto S, Sueishi M, Yoshida T   +9 more
doaj  

Diagnostic Comparison of MRI Sequences for Assessing Myometrial Invasion in Endometrial Cancer: A 1.5T MRI Study

Hitit Medical Journal
Objective: To compare the diagnostic accuracy of T2-weighted, dynamic contrast-enhanced imaging, and diffusion-weighted imaging in assessing myometrial invasion depth in endometrial cancer and to determine if any sequence performs better.
Abdusselim Adil Peker, Ahmet Akçay
doaj   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Scedosporium apiospermum endophthalmitis: diffusion-weighted imaging in detecting subchoroidal abscess

Clinical Ophthalmology, 2012
Sandeep Bhuta, Charlie Chia-Tsong Hsu, Gigi Nga Chi KwanGriffith University, School of Medicine, Department of Medical Imaging, Gold Coast Hospital, Southport, Gold Coast, QLD, AustraliaPurpose: To describe the imaging appearance of Scedosporium ...
Kwan GN, Hsu CC, Bhuta S
doaj  

Diffusion weighted imaging and diffusion kurtosis imaging in abdominal oncological setting: why and when

Infectious Agents and Cancer, 2022
This article provides an overview of diffusion kurtosis (DKI) imaging in abdominal oncology. DKI allows for more data on tissue structures than the conventional diffusion model (DWI).
Vincenza Granata, Roberta Fusco, Andrea Belli, Ginevra Danti, Eleonora Bicci, Carmen Cutolo, Antonella Petrillo, Francesco Izzo   +7 more
doaj   +1 more source