Results 111 to 120 of about 913,955 (304)

Midbrain PAG Astrocytes Modulate Mouse Defensive and Panic‐Like Behaviors

Advanced Science, EarlyView.
Astrocytes in the midbrain periaqueductal gray (PAG) dynamically encode threat intensity and shape defensive action selection in mice. Real‐time Ca2+ imaging reveals robust astrocytic activation during predator odor and CO2 exposure. Aberrant astrocytic Ca2+ overactivation disrupts goal‐directed escape, biases behavior toward freezing, and induces ...
Ellane Barcelon, Kyungchul Noh, Minkyu Hwang, Yoon‐Jung Kim, Unjin Lee, Yeon Joo Ryu, Je‐Kyung Ryu, Sang Beom Jun, Se‐Young Choi, Woo‐Hyun Cho, Sung Joong Lee   +10 more
wiley   +1 more source

The relationship between physical activity level, digital game addiction, and academic success levels of university students

Journal of Global Education and Research
This study examined the relationship between physical activity, digital game addiction, and academic success among university students. Participants were university 704 students from Turkiye who did physical activity and played digital games.
Aydin Ilhan
doaj   +1 more source

Digital Escape Game

Pacific Journal of Technology Enhanced Learning, 2019
The Escape Room phenomena began in Japan in 2007. The premise of an Escape Room is that ‘players’ are locked inside a room and, in order to escape, they must solve a range of puzzles, riddles, and open mechanisms and locks inside a given timeframe.
openaire   +2 more sources

Beyond Catalytic Therapy: Copper‐Paeonol Nanozymes Disrupt Fascin‐Mediated Actin Bundling to Suppress Tumor Growth and Metastasis

Advanced Science, EarlyView.
Copper‐paeonol nanozymes target tumor‐specific reactive oxygen species generation and disrupt fascin‐mediated actin bundling, effectively suppressing tumor growth and metastatic colonization. Abstract Fascin, an actin‐bundling protein universally upregulated in metastatic tumors, drives tumor migration and invasion by promoting filopodia and ...
Peiying Zhang, Huajun Li, Yisen Wang, Jie Xiang, Lei Fan, Shengzhe Zhang, Lizeng Gao, Hua Dai, Juqun Xi   +8 more
wiley   +1 more source

Single‐Cell Metabolic Imaging and Digital Scoring of Fat Tissue Remodeling by Label‐Free Metabolic Microscopy

Advanced Science, EarlyView.
Mid‐infrared optoacoustic microscopy (MiROM) acquires lipid‐ and protein‐ associated vibrational contrast in intact fat tissue without dyes, preserving native tissue architecture. Through lateral and axial segmentation, MiROM tracks intrinsic intracellular changes during postnatal remodeling. A quantitative spatial analysis tool (Q‐SAT) maps white‐ and
Myeongseop Kim, Constantin Berger, Alexander Wolf, Alina Peteranderl, Martin Klingenspor, Vasilis Ntziachristos, Yongguo Li, Miguel A. Pleitez   +7 more
wiley   +1 more source

İnternet Üzerindeki Oyun Sitelerinin Çocuklara Yönelik Riskler Açısından İncelenmesi

Erciyes İletişim Dergisi, 2018
Çocukların ayrılmaz bir parçası olarak algılanan oyun oynamak, çocukların öğrenmelerini, kendilerini ifade etmelerini, keşfetmelerini ve eğlenmelerini sağlamaktadır.
Halil Kayaduman, Mehmet Sağlam
doaj  

Deciphering and Targeting the Schwannoma‐Neuron‐Macrophage Crosstalk for the Treatment of Schwannomatosis and Associated Pain

Advanced Science, EarlyView.
We established patient‐derived SWN cell lines and orthotopic PDX models that recapitulate patient pain phenotypes, alongside a novel intravital DRG imaging platform to track macrophage infiltration and neuronal pain responses. Using these models, we define HMGB1–CCL2–IL‐6 signaling crosstalk driving pain and identify EGF signaling as a key regulator of
Zhenzhen Yin, Limeng Wu, Yanling Zhang, Yao Sun, Grace Y. Lee, Simeng Lu, Xing Gao, John W. Chen, Sonu Subudhi, William Ho, Chao Zhu, Jun Ren, Gino B. Ferraro, Alona Muzikansky, Anat Stemmer‐Rachamimov, Jianren Mao, Scott R. Plotkin, Lei Xu   +17 more
wiley   +1 more source

PENGARUH PENDEKATAN BERMAIN BERBASIS DIGITAL GAME BASED LEARNING (DGBL) TERHADAP PENINGKATAN KERJASAMA DAN KETERAMPILAN BERMAIN SEPAKBOLA [PDF]

, 2016
Tujuan penelitian ini adalah untuk mengetahui pengaruh Pendekatan Bermain Berbasis Digital Game Based Learning (DGBL) terhadap Peningkatan Kerjasama dan Keterampilan Bermain Sepakbola.
Wisaksono, Hendro
core  

High‐Fidelity Synthetic Data Replicates Clinical Prediction Performance in a Million‐Patient Diabetes Cohort

Advanced Science, EarlyView.
This study generates high‐fidelity synthetic longitudinal records for a million‐patient diabetes cohort, successfully replicating clinical predictive performance. However, deeper analysis reveals algorithmic biases and trajectory inconsistencies that escape standard quality metrics. These findings challenge current validation norms, demonstrating why a
Francisco Ortuño, Víctor M. de la Oliva Roque, Javier‐Ignacio Ramirez‐Lopez, David P. Kreil, Joaquín Dopazo, Carlos Loucera   +5 more
wiley   +1 more source

Desain Game Digital sebagai Media Pembelajaran Candi-Candi Kerajaan Singosari [PDF]

, 2015
Salah satu situs bersejarah Indonesia adalah candi-candi peninggalan Kerajaan Singosari. Bila dibandingkan dengan candi-candi lain seperti Candi Borobudur dan Prambanan, situs ini memiliki kondisi jauh lebih buruk karena sulitnya akses.
Nugraha, F. A. (Fierlan)
core