Results 81 to 90 of about 436,970 (323)

Descriptive markup languages and the development of digital humanities

open access: yesLibellarium: Journal for the Research of Writing, Books, and Cultural Heritage Institutions, 2012
The paper discusses the role of descriptive markup languages in the development of digital humanities, a new research discipline that is part of social sciences and humanities, which focuses on the use of computers in research.
Boris Bosančić
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Becoming the Gothic Archive: From Digital Collection to Digital Humanities [PDF]

open access: yes, 2015
The Gothic Archive is the flagship digital humanities project for the Marquette University library. The project was birthed from a simple digital collection, and through the partnership of faculty and librarians, was transformed into something more.
Fortier, Rose, James, Heather G.
core   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

open access: yesMolecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute   +17 more
wiley   +1 more source

Keynote 3

open access: yesPakistan Journal of Information Management & Libraries, 2016
This paper addresses the relationship between Digital Libraries (DL) and Digital Humanities (DH) with a special focus on global access to knowledge. An overview DL & DH and their interconnections are described.
Widad El Hadi
doaj  

A Digital 4D Information System on the World Scale: Research Challenges, Approaches, and Preliminary Results

open access: yesApplied Sciences
Numerous digital media repositories have been set up during recent decades, each containing plenty of data about historic cityscapes. In contrast, digital 3D reconstructions of no longer extant cityscapes have so far almost solely been performed for ...
Sander Münster   +9 more
doaj   +1 more source

Student Labour and Training in Digital Humanities [PDF]

open access: yes, 2016
This article critiques the rhetoric of openness, accessibility and collaboration that features largely in digital humanities literature by examining the status of student labour, training, and funding within the discipline. The authors argue that the use
Deanna Fong   +5 more
core   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

open access: yesMolecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller   +17 more
wiley   +1 more source

DIGITAL HUMANITIES IN HIGHER EDUCATION SYSTEM OF CANADA

open access: yesНеперервна професійна освіта: теорія та практика, 2019
The urgency of the article is due to the increased impact of information and communication technologies on research in the field of socio-humanitarian cycle sciences, which led to the emergence of interdisciplinary direction of research and projects ...
Olena Voskoboinikova-Huzieva
doaj   +1 more source

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