Results 51 to 60 of about 205,289 (220)

Decrypting cancer's spatial code: from single cells to tissue niches

Molecular Oncology, EarlyView.
Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik, Shi Pan, Eloise Withnell, Hou Wang Lam, Maria Secrier   +4 more
wiley   +1 more source

Applying Decision Transformers to Enhance Neural Local Search on the Job Shop Scheduling Problem

AI
Background: The job shop scheduling problem (JSSP) and its solution algorithms have been of enduring interest in both academia and industry for decades.
Constantin Waubert de Puiseau, Fabian Wolz, Merlin Montag, Jannik Peters, Hasan Tercan, Tobias Meisen   +5 more
doaj   +1 more source

City data ecosystems between theory and practice: A qualitative exploratory study in seven European cities

Data & Policy, 2023
The exponential growth of data collection opens possibilities for analyzing data to address political and societal challenges. Still, European cities are not utilizing the potential of data generated by its citizens, industries, academia, and public ...
Giovanni Liva, Marina Micheli, Sven Schade, Alexander Kotsev, Matteo Gori, Cristiano Codagnone   +5 more
doaj   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Transforming document management for environmental sustainability: the mediating effect of pro-environmental culture and service satisfaction in higher education institutions

Frontiers in Sustainability
This research investigates the factors influencing environmental sustainability in a Peruvian higher education institution (HEI), using Structural Equation Modeling (SEM) with SmartPLS.
Jessie Bravo, Carlos Valdivia, Roger Alarcón, Nilton Germán, Oscar Serquén, Janet Aquino, Marco Agustín Arbulú Ballesteros, Laurita Guevara   +7 more
doaj   +1 more source

Chances and Challenges: Transformation from a Laser-Based to a Camera-Based Container Crane Automation System

Journal of Marine Science and Engineering, 2023
In recent years, a steady increase in maritime business and annual container throughput has been recorded. To meet this growing demand, terminal operators worldwide are turning to automated container handling.
Johannes Benkert, Robert Maack, Tobias Meisen   +2 more
doaj   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Characterizing epithelial‐mesenchymal transition‐linked heterogeneity in breast cancer circulating tumor cells at a single‐cell level

Molecular Oncology, EarlyView.
In over 50% of non‐metastatic breast cancer patients, circulating tumor cells (CTCs) along the whole epithelial‐mesenchymal transition spectrum are detected. Total CTC number and individual phenotypes relate to aggressive disease characteristics, including lymph node involvement and higher tumor proliferation. At the single‐cell level, mesenchymal CTCs
Justyna Topa, Julia Richert, Tomasz Stokowy, Alicja Staśczak, Mariusz Szajewski, Maciej Ciesielski, Petra M. Grešner, Bartłomiej Tomasik, Łukasz Arcimowicz, Agnieszka Stankiewicz, Grażyna Suchodolska, Elżbieta Senkus, Wiesław Kruszewski, Anna J. Żaczek, Aleksandra Markiewicz   +14 more
wiley   +1 more source

Implementation of a digital coordination centre in a hospital: a qualitative evaluation of enablers, barriers and strategies

BMC Health Services Research
Background Digital Coordination Centres (DCCs) represent an innovative approach in hospital settings, designed to enhance patient flow, operational efficiency, and real-time decision-making.
Louise Shaw, Sam Freeman, Sarah Aranha, Adam Boulton, Daniel Capurro, Wendy Chapman, Tim Fazio, Jana Gazarek, Meredith Layton, Kayley Lyons, Sam Plumb, Brad Astbury   +11 more
doaj   +1 more source