Results 1 to 10 of about 2,530 (140)

Digitalis Therapy Is Associated With an Increased Risk of ICD Shock Delivery and Device Revision [PDF]

Annals of Noninvasive Electrocardiology
Background Digitalis glycosides are employed for rate control of atrial fibrillation and treatment of heart failure. Previous studies suggested potential harmful effects of digitalis therapy.
Gerrit Frommeyer, Philipp S. Lange, Thomas Kleemann, Christoph Stellbrink, Hüseyin Ince, Johannes Brachmann, Thorsten Lewalter, Matthias Hochadel, Jochen Senges, Lars Eckardt   +9 more
doaj   +3 more sources

Divergent Electrophysiologic Effects of Sacubitril in Digitalis- and Pinacidil-Related Shortened Repolarization: Experimental Evidence for Harmful Effects of Digitalis Glycosides [PDF]

Pharmaceutics
Background: Recent studies reported an abbreviation of cardiac repolarization induced by sacubitril. Thus, the purpose of this study was to evaluate the electrophysiologic effects of sacubitril in the presence of drugs that shorten the QT interval ...
Christian Ellermann, Carlo Mengel, Julian Wolfes, Felix K. Wegner, Benjamin Rath, Florian Reinke, Lars Eckardt, Gerrit Frommeyer   +7 more
doaj   +2 more sources

Analysis of Upper Gastrointestinal Adverse Events Associated with Oral Anticoagulants and Potential Drug Interactions with Cardiovascular Drugs: Exploratory Study Using FDA Adverse Event Reporting System [PDF]

Pharmaceuticals
Background: This study aimed to evaluate the risk of upper gastrointestinal (UGI) adverse events (AEs) associated with oral anticoagulants (OACs) and identify potential interactions with cardiovascular (CV) drugs. Methods: Individual case safety reports (
Seunghyun Cheon, Jiyeon Park, Dosol Oh, Young Seo Kim, Jee-Eun Chung   +4 more
doaj   +2 more sources

Comparative Photosynthetic Induction Reveals Stomatal Limitation and Reduced Efficiency in Digitalis purpurea Versus Cucumis sativus [PDF]

Biology
Digitalis purpurea, valued for its cardiotonic glycosides, remains an important medicinal species. Optimizing cultivation to enhance photosynthetic efficiency is critical for improving both biomass accumulation and metabolite yield.
Yunmin Wei, Xiaohong Xiang, Wei Jin, Haifeng Xiong, Lihong Tan   +4 more
doaj   +2 more sources

Clinical observation of esculin and digitalisglycosides eye drops with 0.3% sodium hyaluronate eye drops for dry eye disease: a randomized controlled trial [PDF]

Scientific Reports
Dry eye disease (DED) is a common ocular surface disorder. Esculin and digitalis possess anti-inflammatory and anti-oxidant properties, which may benefit patients with DED.
Yinghui Wang, Jiahao Yuan, Ya Wen, Siyuan Li, Lei Tian, Ying Jie   +5 more
doaj   +2 more sources

Destructive effect of digitalis overdose on blood-brain barrier in rats; an experimental study [PDF]

Journal of Research in Clinical Medicine, 2020
Introduction: Cardiac glycosides are widely used in critical cardiac diseases despite their unexplained mechanisms on cardio-respiratory system and other autonomic complications within both intra-uterine and post-natal life.
Mehmet Nuri Kocak, Ozgur Caglar, Dilek Destegul, Kemal Alp Nalci, Sevilay Ozmen, Mehmet Dumlu Aydin   +5 more
doaj   +1 more source

Identification of key genes involved in secondary metabolite biosynthesis in Digitalis purpurea

PLoS ONE, 2023
The medicinal plant Digitalis purpurea produces cardiac glycosides that are useful in the pharmaceutical industry. These bioactive compounds are in high demand due to ethnobotany’s application to therapeutic procedures.
Fatemeh Amiri, Ali Moghadam, Ahmad Tahmasebi, Ali Niazi   +3 more
doaj   +2 more sources

High-resolution tandem mass spectrometry dataset reveals fragmentation patterns of cardiac glycosides in leaves of the foxglove plants

Data in Brief, 2020
Cardiac glycosides, steroid derivatives extracted from the foxglove plants, have been used for the treatment of heart failure since the 18th century. A method based on liquid chromatography coupled with high-resolution tandem mass spectrometry (LC/MS2 ...
Baradwaj Gopal Ravi, Mary Grace E. Guardian, Rebecca Dickman, Zhen Q. Wang   +3 more
doaj   +1 more source

Plant Toxins: Poison or Therapeutic?

CHIMIA, 2020
Many plants that are classed as poisonous also have therapeutic uses, and this is illustrated using members of the Drimia and Digitalis genera which are sources of cardiac glycosides.
Catherine E. Housecroft
doaj   +1 more source

A suicide attempt by ingestion of oleander leaves and treatment with digoxin-specific Fab antibody fragments

Arhiv za Higijenu Rada i Toksikologiju, 2023
Natural cardiac glycosides have positive inotropic heart effects but at high, toxic doses they can cause life-threatening cardiac arrhythmias. Here we present the first Croatian case of a 16-year-old girl who attempted suicide by eating dried oleander ...
Kovačević Tanja, Polić Branka, Ardalić Tatjana Ćatipović, Petrović Davor, Stričević Luka, Rogulj Maja, Markić Joško   +6 more
doaj   +1 more source