Results 31 to 40 of about 2,595 (165)

Superior Cardiorenal Protection With Tirzepatide Over Dulaglutide in Heart Failure With Preserved Ejection Fraction: A Large‐Scale Propensity Score–Matched Real‐World Analysis

Clinical Cardiology, Volume 49, Issue 8, August 2026.
In this large real‐world propensity‐matched analysis, tirzepatide demonstrated superior reductions in mortality, hospitalizations, and cardiorenal outcomes versus dulaglutide in HFpEF patients, with a favorable safety profile. ABSTRACT Background No direct head‐to‐head trials compare tirzepatide and dulaglutide in heart failure with preserved ejection ...
Ibrahim Khalil, Md. Imran Hossain, Mst. Mahmuda Akter, Ferdous Wahid, Aizaz Anwar Khalid, Sunjida Amin Promi, Md. Abu Sayed, Mohd Turzo Rahman, Pallab Sarker   +8 more
wiley   +1 more source

All pieces together now? A phylogenomic analysis and tribe‐level classification of the heterogeneous family Plantaginaceae

TAXON, Volume 75, Issue 4, August 2026.
Abstract The plant family Plantaginaceae comprises approximately 2100 species in 106 genera, representing around 1% of all eudicots. The current circumscription of the family has been established in recent decades based on insights from DNA‐based phylogenetic analyses, which have united genera previously considered unrelated.
Niels Kappert, Mario Fernández‐Mazuecos, Ana Otero, Catherine McGinnie, Olivier Maurin, Félix Forest, William J. Baker, Alexandre Rizzo Zuntini, Dirk C. Albach   +8 more
wiley   +1 more source

Aspects of the safe use of medicinal products based on medicinal plant materials in COVID-19

Реальная клиническая практика: данные и доказательства, 2022
According to a number of studies, medicinal plants and drugs based on them can be used as inhibitors of various viral infections, including the SARS-CoV-2 virus at different stages of their manifestation and development.
A. A. Taube
doaj   +1 more source

Ouabain Relieves Sleep Deprivation–Induced Anxiety‐Like Behavior in Mice by Suppressing Hippocampal Neuroinflammation and Oxidative Stress

Brain and Behavior, Volume 16, Issue 7, July 2026.
Low‐dose ouabain effectively counteracts acute SD‐induced oxidative stress in the hippocampus, restoring both enzymatic and non‐enzymatic antioxidant defenses and attenuating lipid peroxidation, thereby reversing acute SD‐induced anxiety‐like behavior.
Hanxiao Zhu, Wei Wang
wiley   +1 more source

Higher sensitivity to ouabain‐induced toxicity in human induced pluripotent stem cell‐derived cardiomyocytes than human adult heart tissue despite similar Na+/K+‐ATPase pump current amplitudes

British Journal of Pharmacology, Volume 183, Issue 11, Page 3093-3110, June 2026.
Abstract Background and Purpose Human induced pluripotent stem cell‐derived cardiomyocytes (hiPSC‐CM) have gained interest as a pharmacological model but their immaturity leads to uncertainty regarding translation. We studied the key player in maintaining ionic homeostasis, the Na+/K+‐ATPase (NKA), in hiPSC‐CM.
Djemail Ismaili, Paavo Virtanen, Junsoo Im, Paul Brunnbauer, Umber Saleem, Muhammed Ikbal Sönmez, Carl Schulz, Margaret Nandudu, Joris Winters, Cristina E. Molina, Johannes Petersen, Monika Stoll, Ulrich Schotten, Arne Hansen, Thomas Eschenhagen, Jussi T. Koivumäki, Torsten Christ   +16 more
wiley   +1 more source

Carbohydrate‐Based Drug Discovery: Synthetic Strategies and Clinical Applications

Israel Journal of Chemistry, Volume 66, Issue 3, May 2026.
The picture depicts the molecules discussed in the review. On the left side, the general scaffold of sugars is shown. Next to it are four carbohydrate‐based molecules, including remdesivir, islatravir, empagliflozin, and Globo‐H. Remdesivir and islatravir contain a substituted ribose ring attached to a modified nucleobase.
Stephan Scheeff, Jemma Arakelyan, Billy Wai‐Lung Ng   +2 more
wiley   +1 more source

Spherical oligo-silicic acid SOSA disclosed as possible endogenous digitalis-like factor

Frontiers in Endocrinology, 2015
Na+/K+-ATPase is a membrane ion-transporter protein, specifically inhibited by digitalis glycosides used in cardiac-therapy. The existence in mammals of some endogenous digitalis-like factors (EDLF) as presumed ATPase ligands is generally accepted.
Franz eKerek, Victor A Voicu
doaj   +1 more source

Possible Deslanoside‐Induced Left Posterior Fascicular Ventricular Tachycardia: A Case Report

Annals of Noninvasive Electrocardiology, Volume 31, Issue 3, May 2026.
A 73‐year‐old man with paroxysmal AF and no structural heart disease who developed left posterior fascicular ventricular tachycardia (LPFVT) shortly after intravenous Deslanoside administration for rate control. Highlights: cardiac glycosides, though effective for rate control, may occasionally precipitate Purkinje‐related ventricular tachycardia ...
Zhang Wenjun, Chen Yao
wiley   +1 more source

Considerations about Study on Mechanisms of Acupuncture Underlying Efficacy-enhancement and Toxicity-attenuation of Digitalis Drugs for Heart Failure

针刺研究, 2011
Digitalis glycosides,a group of cardiotonic agents for heart failure,have been used for a long time,but may often trigger arrhythmias as a result of digitalis intoxication.It is of great significance in finding a method to reduce their toxicity and ...
MA Shu-hua1, GAO Jun-hong2, WANG Yu-min1, ZHANG Meng3, MA Yan-yan1, HU Jian-jiang1, FU Wei-xing2, CUI Hai-feng1, YU Xiao-chun1   +8 more
doaj  

Environment and Pollen Diversity Differentially Affect the Gut Microbiomes of Introduced Honeybees and Bumblebees

Evolutionary Applications, Volume 19, Issue 4, April 2026.
ABSTRACT Invasive species may exhibit shifts in their gut microbiome in response to novel environments and diet, but this may differ across host species and their time since colonisation. We investigate if site environmental variables and foraged pollen resources differentially shape the gut microbiomes of two bee species with contrasting introduction ...
Sabrina Haque, Fleur Ponton, Andrew P. Allen, Hasinika K. A. H. Gamage, Francisco Encinas‐Viso, Ian T. Paulsen, Rachael Y. Dudaniec   +6 more
wiley   +1 more source