Results 11 to 20 of about 2,595 (165)

From WGS to gels: Development and testing of PCR primers targeting toxic <i>Digitalis</i> in support of food safety. [PDF]

Appl Plant Sci
Abstract Premise This study capitalized on a library of single‐nucleotide polymorphisms created via whole genome sequencing (WGS) to develop and test a PCR assay for detecting toxic Digitalis species in food products. Complex foods can be difficult to analyze, but safeguarding consumer well‐being and public health necessitates that products regulated ...
Hunter ES, Fo S, Literman R, Uva RH, Wolny JL, Handy SM.   +5 more
europepmc   +2 more sources

Cardenolide-Engineered Extracellular Vesicles Augment Drug Uptake and Cytotoxicity in Non-small Cell Lung Cancer Cells. [PDF]

Small Methods
Cardenolide‐functionalized extracellular vesicles enable targeted delivery of the chemotherapeutic doxorubicin to A549 lung cancer cells by binding Na+/K+‐ATPase, which is overexpressed in these cells. Surface‐modified, drug‐loaded EVs exhibit enhanced cytotoxicity compared to unmodified EVs and free drug, suggesting this system may lower the effective
Dorfner M, Mifka A, de Pádua RM, da Silva IT, Guterres IZ, Sana L, Fuhrmann G, Munkert J.   +7 more
europepmc   +2 more sources

Variation in the chemical profiles of three foxglove species in the central Balkans

Frontiers in Plant Science, 2023
The aim of this study was to determine intra- and interspecies variation in the qualitative and quantitative composition of methanol-soluble metabolites in the leaves of three Digitalis species (D. lanata, D. ferruginea, and D.
Uroš Gašić, Tijana Banjanac, Branislav Šiler, Jelena Božunović, Milica Milutinović, Neda Aničić, Slavica Dmitrović, Marijana Skorić, Jasmina Nestorović Živković, Luka Petrović, Miloš Todorović, Suzana Živković, Dragana Matekalo, Biljana Filipović, Tamara Lukić, Danijela Mišić   +15 more
doaj   +1 more source

Comprehensive analysis of alternative splicing in Digitalis purpurea by strand-specific RNA-Seq. [PDF]

PLoS ONE, 2014
Digitalis purpurea (D. purpurea) is one of the most important medicinal plants and is well known in the treatment of heart failure because of the cardiac glycosides that are its main active compounds. However, in the absence of strand specific sequencing
Bin Wu, Fengmei Suo, Wanjun Lei, Lianfeng Gu   +3 more
doaj   +1 more source

Risk of Hospitalization for Adverse Drug Events in Women and Men: A Post Hoc Analysis of an Active Pharmacovigilance Study in Italian Emergency Departments

Pharmaceuticals, 2021
This post hoc analysis of an Italian active pharmacovigilance study describes pharmacological differences of ADEs leading to emergency department (ED) visits and hospitalization in women and men.
Giada Crescioli, Ennio Boscia, Alessandra Bettiol, Silvia Pagani, Giulia Spada, Giuditta Violetta Vighi, Roberto Bonaiuti, Mauro Venegoni, Giuseppe Danilo Vighi, Alfredo Vannacci, Niccolò Lombardi, on behalf of the MEREAFaPS Study Group   +11 more
doaj   +1 more source

Endogenous Digitalis-like Factors: An Overview of the History

Frontiers in Endocrinology, 2015
The sodium pump is a ubiquitous cell surface enzyme, a Na, K ATPase, which maintains ion gradients between cells and the extracellular fluid (ECF). The extracellular domain of this enzyme contains a highly conserved binding site, a receptor for a plant ...
Vardaman eBuckalew
doaj   +1 more source

Cardiac Glycoside Plants Self-Poisoning

Acta Medica Bulgarica, 2014
Cardiac glycosides are found in a diverse group of plants including Digitalis purpurea and Digitalis lanata (foxgloves), Nerium oleander, Convallaria majalis (lily of the valley), Strophanthus gratus, etc.
Radenkova-Saeva J., Atanasov P.
doaj   +1 more source

Effects of adding digitoxigenin and gitoxigenin to the nutrient medium on cardiac glycosides production from digitalis purpurea (Var. Excelsior Mixed) by using tissue culture technique

Al-Mustansiriyah Journal of Pharmaceutical Sciences, 2004
The present study was performed using tissue culture technique purpose of knowing the effect of using precursors in the presence of TDZ semi–cytokinin and maltos sugar on the cardiac glycosides constituents shoots of Digitalis purpurea digitoxin ...
AL–Khateeb H. Ekbal, Awad J. Zeinab
doaj   +1 more source

INCREASING PRODUCTIVITY OF DIGOXIN CONTENT IN DIGITALIS LANATA EHRH "IN VITRO" [PDF]

Journal of Plant Production, 2009
Axillary buds Cultures of Digitalis lanata Ehrh were established from seedling, obtained under aseptic conditions. Shoot tip and single node explants were cultured on MS basal solid medium with various of BA concentrations.
M. H. Bekhit
doaj   +1 more source

Duckweeds: Model organisms for research on plant sterols and steroids. [PDF]

Plant Biol (Stuttg)
Duckweeds (Lemnaceae), the fastest‐growing angiosperms and promising vegan protein source, offer a powerful model to address key questions in plant physiology. This article highlights their potential for dissecting the biosynthesis and function of phytosterols, sterol conjugates, brassinosteroids, and specialized steroidal metabolites, such as ...
Klein J, Appenroth KJ, Sree KS.
europepmc   +2 more sources