Endogenous Digitalis-like Factors: An Overview of the History
The sodium pump is a ubiquitous cell surface enzyme, a Na, K ATPase, which maintains ion gradients between cells and the extracellular fluid (ECF). The extracellular domain of this enzyme contains a highly conserved binding site, a receptor for a plant ...
Vardaman eBuckalew
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Effects of sacubitril/valsartan in the PARADIGM-HF Trial (Prospective Comparison of ARNI with ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure) according to background therapy [PDF]
Background—In the PARADIGM-HF trial (Prospective Comparison of ARNI with ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure), the angiotensin receptor neprilysin inhibitor sacubitril/valsartan was more effective than the ...
Gong, Jianjian+11 more
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The present study was performed using tissue culture technique purpose of knowing the effect of using precursors in the presence of TDZ semi–cytokinin and maltos sugar on the cardiac glycosides constituents shoots of Digitalis purpurea digitoxin ...
AL–Khateeb H. Ekbal, Awad J. Zeinab
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Drugs increase the risk of suicide in the elderly
The purpose of this paper is a systematic review of articles and research in the context of drugs used and suicide in elderly patients. Suicide in the elderly may be much more frequent than in the younger population.
Kornelia Kędziora-Kornatowska+6 more
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Foxglove (Digitalis purpurea L.) leaves are frequently confused with borage (Borago officinalis L.), which is traditionally used as a food ingredient. Due to the presence of the cardiac glycosides, mostly digitoxin, foxglove leaves are poisonous to human
Maria Silvia Negroni+11 more
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Inhibitory effect of combinations of digoxin and endogenous cardiotonic steroids on Na+/K+-ATPase activity in human kidney membrane preparation [PDF]
AimsCardiac glycosides have been extensively used in the treatment of congestive heart failure for more than 200years. Recently, cardenolides and bufadienolides were isolated from mammalian tissue and are considered as a new class of steroidal hormones ...
Cunha-Filho, Geraldino+5 more
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The aim of the present research is to obtain relationship between different stress treatments [Cu (copper) and Hg (mercury)] and content of cardiac glycosides (digoxigenin, gitoxigenin, lanatoside C, digoxin and digitoxin) as secondary metabolites of ...
Gunce Sahin+2 more
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Separation of digoxin by luiquid-luiquid extraction from extracts of foxglove secondary glycosides [PDF]
The present study deals with the extraction of digoxin (Dgx) from chloroform and trichloroethylene extracts of the secondary glycosides of fermented foxglove (Digitalis lanata Ehrh.) foliage by liquid-liquid extraction. The extraction degree (ED)
Novković Vesna V.+4 more
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Acute myocardial uptake of digoxin in humans: Correlation with hemodynamic and electrocardiographic effects [PDF]
Acute myocardial uptake of digoxin was measured at a constant paced heart rate (75 beats/min) for 30 min after an intravenous bolus injection of 500 µg of digoxin in 14 patients with ischemic heart disease.
Hasin, Yonathan+5 more
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Aspects of the safe use of medicinal products based on medicinal plant materials in COVID-19
According to a number of studies, medicinal plants and drugs based on them can be used as inhibitors of various viral infections, including the SARS-CoV-2 virus at different stages of their manifestation and development.
A. A. Taube
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