Emerging roles for diguanylate cyclase during the evolution of soma in dictyostelia [PDF]
BMC Ecology and Evolution, 2023 Background Cyclic di-guanylate (c-di-GMP), synthesized by diguanylate cyclase, is a major second messenger in prokaryotes, where it triggers biofilm formation.
Yoshinori Kawabe +6 more
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Bordetella bronchiseptica diguanylate cyclase BdcB inhibits the type three secretion system and impacts the immune response [PDF]
Scientific Reports, 2023 Bordetella bronchiseptica is a gram-negative bacterium that causes respiratory diseases in different animals, including mice, making B. bronchiseptica the gold-standard model to investigate host–pathogen interaction at the molecular level.
Keila Belhart +3 more
doaj +4 more sources
Calcium-Responsive Diguanylate Cyclase CasA Drives Cellulose-Dependent Biofilm Formation and Inhibits Motility in Vibrio fischeri [PDF]
mBio, 2021 The marine bacterium Vibrio fischeri colonizes its host, the Hawaiian bobtail squid, in a manner requiring both bacterial biofilm formation and motility. The decision to switch between sessile and motile states is often triggered by environmental signals
Alice H. Tischler +3 more
doaj +3 more sources
Activation mechanism of a small prototypic Rec-GGDEF diguanylate cyclase [PDF]
Nature Communications, 2021 As part of two-component systems, diguanylate cyclases (DGCs) are activated by phosphorylation. Structural and computational analyses of DgcR, a model DGC, reveal the phosphorylation-induced conformational changes and the activation mechanism likely ...
Raphael D. Teixeira +2 more
doaj +9 more sources
Structural basis for diguanylate cyclase activation by its binding partner in Pseudomonas aeruginosa [PDF]
eLife, 2021 Cyclic-di-guanosine monophosphate (c-di-GMP) is an important effector associated with acute-chronic infection transition in Pseudomonas aeruginosa. Previously, we reported a signaling network SiaABCD, which regulates biofilm formation by modulating c-di ...
Gukui Chen +10 more
doaj +3 more sources
Distinct strategies of diguanylate cyclase domain proteins on inhibition of virulence and interbacterial competition by agrobacteria [PDF]
mBioDiguanylate cyclases (DGCs) synthesize bis-(3′,5′)-cyclic diguanylic acid (c-di-GMP), a critical bacterial second messenger that coordinates diverse biological processes.
Xuan Lai +3 more
doaj +3 more sources
The diguanylate cyclase and phosphodiesterase locally regulate the virulence factors in Vibrio vulnificus [PDF]
Gut PathogensVibrio vulnificus is a marine pathogen that is a significant cause of foodborne infections, leading to chronic diseases and primary septicemia. Wound infections caused by this bacterium can result in serious complications such as ulceration and tissue ...
Jhih-Ren Yang +3 more
doaj +2 more sources
An O2-sensing diguanylate cyclase broadly affects the aerobic transcriptome in the phytopathogen Pectobacterium carotovorum [PDF]
Frontiers in Microbiology, 2023 Pectobacterium carotovorum is an important plant pathogen responsible for the destruction of crops through bacterial soft rot, which is modulated by oxygen (O2) concentration. A soluble globin coupled sensor protein, Pcc DgcO (also referred to as PccGCS)
Florian J. Fekete +4 more
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Identification of a diguanylate cyclase expressed in the presence of plants and its application for discovering candidate gene products involved in plant colonization by Pantoea sp. YR343. [PDF]
PLoS ONE, 2021 Microbial colonization of plant roots is a highly complex process that requires the coordination and regulation of many gene networks, yet the identities and functions of many of these gene products have yet to be discovered. Pantoea sp.
Amber N Bible +2 more
doaj +2 more sources
Cyclic‐di‐GMP signalling and biofilm‐related properties of the Shiga toxin‐producing 2011 German outbreak Escherichia coli O104:H4 [PDF]
EMBO Molecular Medicine, 2014 In 2011, nearly 4,000 people in Germany were infected by Shiga toxin (Stx)‐producing Escherichia coli O104:H4 with > 22% of patients developing haemolytic uraemic syndrome (HUS).
Anja M Richter +3 more
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