The importance of conserved amino acids in heme-based globin-coupled diguanylate cyclases.
PLoS ONE, 2017 Globin-coupled diguanylate cyclases contain globin, middle, and diguanylate cyclase domains that sense O2 to synthesize c-di-GMP and regulate bacterial motility, biofilm formation, and virulence.
Xuehua Wan +4 more
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Protein allostery. computational characterization of diguanylate cyclase PleD [PDF]
, 2009 In biology, accurate cellular regulation in response to environmental signals is crucial for the fitness of organisms. On the molecular level the modulation of protein activity is often achieved by the binding of a signaling molecule or by covalent ...
Schmid, Franziska F.-F.
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Diguanylate Cyclases in Vibrio cholerae: Essential Regulators of Lifestyle Switching [PDF]
Frontiers in Cellular and Infection Microbiology, 2020 Biofilm formation in Vibrio cholerae empowers the bacteria to lead a dual lifestyle and enhances its infectivity. While the formation and dispersal of the biofilm involves multiple components—both proteinaceous and non-proteinaceous, the key to the ...
Sumit Biswas +2 more
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mBio, 2016 Cell division arrest is a universal checkpoint in response to environmental assaults that generate cellular stress. In bacteria, the cyclic di-GMP (c-di-GMP) signaling network is one of several signal transduction systems that regulate key processes in ...
Hyo Kyung Kim, Rasika M. Harshey
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Comparative analysis of diguanylate cyclase and phosphodiesterase genes in
BMC Microbiology, 2012 Background Klebsiella pneumoniae can be found in environmental habitats as well as in hospital settings where it is commonly associated with nosocomial infections.
Cruz Diana P +4 more
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Cyclic Diguanylate Signaling Proteins Control Intracellular Growth of
mBio, 2011 Proteins that metabolize or bind the nucleotide second messenger cyclic diguanylate regulate a wide variety of important processes in bacteria. These processes include motility, biofilm formation, cell division, differentiation, and virulence.
Assaf Levi +3 more
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Structural analysis of an oxygen-regulated diguanylate cyclase
Acta Crystallographica Section D Biological Crystallography, 2015 Cyclic di-GMP is a bacterial second messenger that is involved in switching between motile and sessile lifestyles. Given the medical importance of biofilm formation, there has been increasing interest in understanding the synthesis and degradation of ...
Schlichting, I. +5 more
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ASSESSMENT OF A PREDICTED DIGUANYLATE CYCLASE IN TREPONEMA DENTICOLA [PDF]
, 2018 Periodontal disease is a progressive inflammatory condition that is characterized by the reabsorption of alveolar bone, the destruction of connective tissue, and edentulism. It is caused by a dysbiosis in the oral microbiome as a result of a shift from a
Patel, Dhara T
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Characterization and analysis of a novel diguanylate cyclase PA0847 from Pseudomonas aeruginosa PAO1
Infection and Drug Resistance, 2019 Yan Zhang,1,2 Jiayi Guo,1 Ning Zhang,2 Wensu Yuan,2 Zhi Lin,2 Weidong Huang11Department of Biochemistry and Molecular Biology, School of Basic Medicine, Ningxia Medical University, Yinchuan 750004, People’s Republic of China; 2School of Life ...
Zhang Y +5 more
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Archaeal Genes Code for GGDEF Domain Proteins With Diguanylate Cyclase Activity. [PDF]
Mol MicrobiolA biofilm‐like mode of growth is hypothesized to be required for the emergence of cellular life. Occurrence of common biofilm gene products in current Bacteria and Archaea is an indication for their previous presence in the last universal common ancestor LUCA and perhaps even in the first universal common ancestor FUCA.
Sidorov R +6 more
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