Results 21 to 30 of about 3,724 (177)
Protein allostery. computational characterization of diguanylate cyclase PleD [PDF]
, 2009 In biology, accurate cellular regulation in response to environmental signals is crucial for the fitness of organisms. On the molecular level the modulation of protein activity is often achieved by the binding of a signaling molecule or by covalent modifications such as phosphorylation by kinases.
Schmid, Franziska F.-F.
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Structural basis of activity and allosteric control of diguanylate cyclase [PDF]
Proceedings of the National Academy of Sciences, 2004 Recent discoveries suggest that a novel second messenger, bis-(3′→5′)-cyclic di-GMP (c-diGMP), is extensively used by bacteria to control multicellular behavior. Condensation of two GTP to the dinucleotide is catalyzed by the widely distributed diguanylate cyclase (DGC or GGDEF) domain that occurs in various combinations with sensory and ...
Chan, C. +6 more
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Cooperative Substrate Binding by a Diguanylate Cyclase
Journal of Molecular Biology, 2015 XAC0610, from Xanthomonas citri subsp. citri, is a large multi-domain protein containing one GAF (cGMP-specific phosphodiesterases, adenylyl cyclases and FhlA) domain, four PAS (Per-Arnt-Sim) domains and one GGDEF domain. This protein has a demonstrable in vivo and in vitro diguanylate cyclase (DGC) activity that leads to the production of cyclic di ...
Maycon C, Oliveira +5 more
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Diguanylate Cyclases in Vibrio cholerae: Essential Regulators of Lifestyle Switching [PDF]
Frontiers in Cellular and Infection Microbiology, 2020 Biofilm formation in Vibrio cholerae empowers the bacteria to lead a dual lifestyle and enhances its infectivity. While the formation and dispersal of the biofilm involves multiple components—both proteinaceous and non-proteinaceous, the key to the ...
Sumit Biswas +2 more
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mBio, 2016 Cell division arrest is a universal checkpoint in response to environmental assaults that generate cellular stress. In bacteria, the cyclic di-GMP (c-di-GMP) signaling network is one of several signal transduction systems that regulate key processes in ...
Hyo Kyung Kim, Rasika M. Harshey
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Cyclic Diguanylate Signaling Proteins Control Intracellular Growth of
mBio, 2011 Proteins that metabolize or bind the nucleotide second messenger cyclic diguanylate regulate a wide variety of important processes in bacteria. These processes include motility, biofilm formation, cell division, differentiation, and virulence.
Assaf Levi +3 more
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Comparative analysis of diguanylate cyclase and phosphodiesterase genes in
BMC Microbiology, 2012 Background Klebsiella pneumoniae can be found in environmental habitats as well as in hospital settings where it is commonly associated with nosocomial infections.
Cruz Diana P +4 more
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Diguanylate cyclase activity of the Mycobacterium leprae T cell antigen ML1419c [PDF]
Microbiology (United Kingdom), 2016 The second messenger, bis-(3',5')-cyclic dimeric guanosine monophosphate (cyclic di-GMP), is involved in the control of multiple bacterial phenotypes, including those that impact host-pathogen interactions. Bioinformatics analyses predicted that Mycobacterium leprae, an obligate intracellular bacterium and the causative agent of leprosy, encodes three ...
Suwatchareeporn Rotcheewaphan +2 more
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Characterization and analysis of a novel diguanylate cyclase PA0847 from Pseudomonas aeruginosa PAO1
Infection and Drug Resistance, 2019 Yan Zhang,1,2 Jiayi Guo,1 Ning Zhang,2 Wensu Yuan,2 Zhi Lin,2 Weidong Huang11Department of Biochemistry and Molecular Biology, School of Basic Medicine, Ningxia Medical University, Yinchuan 750004, People’s Republic of China; 2School of Life ...
Zhang Y +5 more
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Diguanylate cyclase DgcP is involved in plant and human Pseudomonas spp. infections. [PDF]
Environmental microbiology, 2015 Peer ...
Aragon, IM +7 more
core +6 more sources