Comparative analysis of diguanylate cyclase and phosphodiesterase genes in
BMC Microbiology, 2012 Background Klebsiella pneumoniae can be found in environmental habitats as well as in hospital settings where it is commonly associated with nosocomial infections.
Cruz Diana P +4 more
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Structural studies of the periplasmic portion of the diguanylate cyclase CdgH from Vibrio cholerae [PDF]
Scientific Reports, 2017 Cyclic diguanylate monophosphate (c-di-GMP) is a second messenger involved in bacterial signal transduction and produced by diguanylate cyclases (DGCs) generally containing highly variable periplasmic signal-recognition domains. CdgH is a DGC enzyme that
Min Xu +4 more
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The Diguanylate Cyclase YfiN of Pseudomonas aeruginosa Regulates Biofilm Maintenance in Response to Peroxide. [PDF]
J Bacteriol, 2022 Katharios-Lanwermeyer S +3 more
europepmc +2 more sources
Identification of a Diguanylate Cyclase That Facilitates Biofilm Formation on Electrodes by Shewanella oneidensis MR-1. [PDF]
Appl Environ Microbiol, 2021 Matsumoto A +4 more
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Design of novel hybrid secondary metabolite targets to diguanylate cyclase of Acinetobacter baumannii. [PDF]
FEMS Microbes, 2021 AbstractBiofilm formation in bacteria is a resistance determinant and is positively regulated by cyclic diguanylate signaling. This signaling is a near universal signaling, and c-di-GMP produced by diguanylate cyclase (DGC) in this signaling is involved in different bacterial behaviors.
Tiwari M, Joshi R, Tiwari V.
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Studying GGDEF Domain in the Act: Minimize Conformational Frustration to Prevent Artefacts
Life, 2021 GGDEF-containing proteins respond to different environmental cues to finely modulate cyclic diguanylate (c-di-GMP) levels in time and space, making the allosteric control a distinctive trait of the corresponding proteins.
Federico Mantoni +10 more
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π-Helix controls activity of oxygen-sensing diguanylate cyclases [PDF]
Bioscience Reports, 2020 Abstract The ability of organisms to sense and adapt to oxygen levels in their environment leads to changes in cellular phenotypes, including biofilm formation and virulence. Globin coupled sensors (GCSs) are a family of heme proteins that regulate diverse functions in response to O2 levels, including modulating synthesis of cyclic ...
Johnnie A. Walker +3 more
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Identification of flgZ as a flagellar gene encoding a PilZ domain protein that regulates swimming motility and biofilm formation in Pseudomonas. [PDF]
PLoS ONE, 2014 Diguanylate cyclase and phosphodiesterase enzymatic activities control c-di-GMP levels modulating planktonic versus sessile lifestyle behavior in bacteria.
Francisco Martínez-Granero +8 more
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GGDEF domain as spatial on-switch for a phosphodiesterase by interaction with landmark protein HubP
npj Biofilms and Microbiomes, 2022 In bacteria, the monopolar localization of enzymes and protein complexes can result in a bimodal distribution of enzyme activity between the dividing cells and heterogeneity of cellular behaviors.
Tim Rick +12 more
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Bacteriophage‐mediated interference of the c‐di‐GMP signalling pathway in Pseudomonas aeruginosa
Microbial Biotechnology, 2021 Summary C‐di‐GMP is a key signalling molecule which impacts bacterial motility and biofilm formation and is formed by the condensation of two GTP molecules by a diguanylate cyclase.
Jeroen De Smet +7 more
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