Results 41 to 50 of about 5,655 (194)

Structural basis of activity and allosteric control of diguanylate cyclase [PDF]

Proceedings of the National Academy of Sciences, 2004
Recent discoveries suggest that a novel second messenger, bis-(3′→5′)-cyclic di-GMP (c-diGMP), is extensively used by bacteria to control multicellular behavior. Condensation of two GTP to the dinucleotide is catalyzed by the widely distributed diguanylate cyclase (DGC or GGDEF) domain that occurs in various combinations with sensory and ...
Chan, C., Paul, R., Samoray, D., Amiot, N. C., Giese, B., Jenal, U., Schirmer, T.   +6 more
openaire   +4 more sources

A novel c-di-GMP signal system regulates biofilm formation in Pseudomonas aeruginosa

Microbial Cell, 2020
The bacterial second messenger cyclic-di-GMP (c-di-GMP) controls biofilm formation and other phenotypes relevant to pathogenesis. The human pathogen Pseudomonas aeruginosa encodes 17 diguanylate cyclase (DGCs) proteins which are required for c-di-GMP ...
Gukui Chen, Haihua Liang
doaj   +1 more source

Bacterial rotary export ATPases are allosterically regulated by the nucleotide second messenger cyclic-di-GMP [PDF]

, 2015
The widespread second messenger molecule cyclic di-GMP (cdG) regulates the transition from motile and virulent lifestyles to sessile, biofilm-forming ones in a wide range of bacteria. Many pathogenic and commensal bacterial-host interactions are known to
Abel, Aldridge, Amikam, Aragón, Barahona, Baraquet, Bell, Benach, Bingle, Boehm, Boyd, Brencic, Christen, Clare E.M. Stevenson, Compant, Cuppels, David M. Lawson, De, Duerig, Eleftheria Trampari, Emsley, Engl, Fazli, Gal, Galibert, Gledhill, Haas, Hengge, Hickman, Ho, Hughes, Iino, Imada, Jacob G. Malone, Jonas, Kelley, Krasteva, Krissinel, Kuchma, Kuchma, Kulasakara, Lee, Lindeberg, Little, Lovering, Lucchini, Lugtenberg, Macnab, Macnab, Martínez-Granero, Matilla, McNicholas, Miller, Minamino, Minamino, Minamino, Minamino, Minamino, Minamino, Minamino, Minamino, Moscoso, Moscoso, Naseby, Navazo, Nesper, Newell, Newell, Pfeilmeier, Pultz, Pérez-Mendoza, Qi, Rainey, Richard H. Little, Roelofs, Ryan, Schirmer, Solano, Srivastava, Starkey, Steiner, Story, Sudarsan, Tchigvintsev, Thomas Wilhelm, Tschowri, Wassmann, Wilhelm, Woodcock, Xin   +89 more
core   +1 more source

Investigating the allosteric regulation of YfiN from Pseudomonas aeruginosa: clues from the structure of the catalytic domain. [PDF]

PLoS ONE, 2013
Pseudomonas aeruginosa is responsible for a plethora of biofilm mediated chronic infections among which cystic fibrosis pneumonia is the most frightening. The long-term survival strategy of P.
Giorgio Giardina, Alessandro Paiardini, Silvia Fernicola, Stefano Franceschini, Serena Rinaldo, Valentina Stelitano, Francesca Cutruzzolà   +6 more
doaj   +1 more source

New insights into Legionella pneumophila biofilm regulation by c-di-GMP signaling [PDF]

, 2016
The waterborne pathogen Legionella pneumophila grows as a biofilm, freely or inside amoebae. Cyclic-di-GMP (c-di-GMP), a bacterial second messenger frequently implicated in biofilm formation, is synthesized and degraded by diguanylate cyclases (DGCs) and
Allombert, Julie, Doublet, Patricia, Lajoie Halova, Barbora, Pécastaings, Sophie, Roques, Christine, Vianney, Anne   +5 more
core   +3 more sources

Cyclic Diguanylate Signaling Proteins Control Intracellular Growth of Legionella pneumophila

mBio, 2011
Proteins that metabolize or bind the nucleotide second messenger cyclic diguanylate regulate a wide variety of important processes in bacteria. These processes include motility, biofilm formation, cell division, differentiation, and virulence.
Assaf Levi, Marc Folcher, Urs Jenal, Howard A. Shuman   +3 more
doaj   +1 more source

The cyclic-di-GMP signaling pathway in the Lyme disease spirochete, [PDF]

, 2014
In nature, the Lyme disease spirochete Borrelia burgdorferi cycles between the unrelated environments of the Ixodes tick vector and mammalian host. In order to survive transmission between hosts, B.
Adams, Adams, Albright, Amikam, Andrade, Armitage, Barends, Barrett, Beier, Benach, Berg, Bian, Blevins, Boardman, Bobrov, Boehm, Boylan, Brisson, Brooks, Brown, Burgdorfer, Burtnick, Caimano, Caimano, Caimano, Carroll, Carroll, Casjens, Chae, Chang, Chang, Charon, Chatterjee, Christen, Christen, Christen, Cotter, Duerig, Dunham-Ems, Fang, Fazli, Fisher, Fraser, Freedman, Fries, Galperin, Galperin, Galperin, Girgis, Goldman, Groshong, Habazettl, HajduÅ¡ek, Hammer, He, He, Hengge, Hickman, Hickman, Hyde, Hyde, Hübner, Jenal, Katona, Kazmierczak, Kim, Ko, Kostick, Krasteva, Kuehn, Kulasekara, Lai, Lane, Lee, Levine, Li, Luo, Maes, Massie, Mather, McCarthy, Merighi, Monds, Moriarty, Motaleb, Motaleb, Nickels, Norman, Ojaimi, Ojaimi, Ostfeld, Ouyang, Ouyang, Ouyang, Ouyang, Pappas, Paul, Paul, Pazy, Pesavento, Pitzer, Pratt, Radolf, Revel, Rogers, Ross, Russell, Ryan, Ryan, Ryan, Ryan, Ryan, Ryjenkov, Ryjenkov, Römling, Römling, Römling, Römling, Samuels, Samuels, Schirmer, Schmidt, Schmidt, Seshu, Silversmith, Smith, Sommerfeldt, Sonenshine, Sonenshine, Stelitano, Stock, Sudarsan, Sultan, Sultan, Sze, Sze, Tal, Tam, Tamayo, Tamayo, Tamayo, Tao, Thomas, Tilly, Tokarz, Trappetti, Tsao, Tuckerman, Tuckerman, Vvedenskaya, Weber, West, Wolfe, Xu, Yang, Yang, Yildiz, Yildiz, Zhang, Zorraquino   +159 more
core   +2 more sources

A Diguanylate Cyclase Acts as a Cell Division Inhibitor in a Two-Step Response to Reductive and Envelope Stresses

mBio, 2016
Cell division arrest is a universal checkpoint in response to environmental assaults that generate cellular stress. In bacteria, the cyclic di-GMP (c-di-GMP) signaling network is one of several signal transduction systems that regulate key processes in ...
Hyo Kyung Kim, Rasika M. Harshey
doaj   +1 more source

Diguanylate Cyclase Activation: It Takes Two [PDF]

Structure, 2007
Characterization of an activated diguanylate cyclase reported in this issue of Structure by Wassmann et al. (2007) reveals how phosphorylation promotes dimerization necessary for synthesis of the second messenger c-di-GMP, establishes the catalytic mechanism, and identifies a widely conserved mode of product inhibition.
openaire   +1 more source

Diguanylate Cyclases Control Magnesium-Dependent Motility ofVibrio fischeri [PDF]

Journal of Bacteriology, 2006
ABSTRACTFlagellar biogenesis and hence motility ofVibrio fischeridepends upon the presence of magnesium. In the absence of magnesium, cells contain few or no flagella and are poorly motile or nonmotile. To dissect the mechanism by which this regulation occurs, we screened transposon insertion mutants for those that could migrate through soft agar ...
Therese M, O'Shea, Adam H, Klein, Kati, Geszvain, Alan J, Wolfe, Karen L, Visick   +4 more
openaire   +2 more sources