c-di-GMP-related phenotypes are modulated by the interaction between a diguanylate cyclase and a polar hub protein. [PDF]
Sci Rep, 2020 c-di-GMP is a major player in the switch between bioflm and motile lifestyles. Several bacteria exhibit a large number of c-di-GMP metabolizing proteins, thus a fne-tuning of this nucleotide levels may occur.
Nicastro GG +10 more
europepmc +2 more sources
Activation and polar sequestration of PopA, a c-di-GMP effector protein involved in Caulobacter crescentus cell cycle control [PDF]
, 2014 When Caulobacter crescentus enters S-phase the replication initiation inhibitor CtrA dynamically positions to the old cell pole to be degraded by the polar ClpXP protease.
Ebbensgaard, Anna Elisabeth +7 more
core +1 more source
mBio, 2013 WspR is a hybrid response regulator-diguanylate cyclase that is phosphorylated by the Wsp signal transduction complex in response to growth of Pseudomonas aeruginosa on surfaces.
Varisa Huangyutitham +2 more
doaj +1 more source
Specialized and shared functions of diguanylate cyclases and phosphodiesterases in Streptomyces development [PDF]
Molecular Microbiology, 2020 Abstract Levels of the second messenger bis-3’-5’-cyclic di-guanosinemonophosphate (c-di-GMP) determine when Streptomyces initiate sporulation to survive under adverse conditions. c-di-GMP signals are integrated into the genetic differentiation network by the regulator BldD and the ...
Haist, Julian +5 more
openaire +2 more sources
A novel c-di-GMP signal system regulates biofilm formation in Pseudomonas aeruginosa
Microbial Cell, 2020 The bacterial second messenger cyclic-di-GMP (c-di-GMP) controls biofilm formation and other phenotypes relevant to pathogenesis. The human pathogen Pseudomonas aeruginosa encodes 17 diguanylate cyclase (DGCs) proteins which are required for c-di-GMP ...
Gukui Chen, Haihua Liang
doaj +1 more source
Structural elucidation of the multidomain response regulator PleD using X-ray crystallography [PDF]
, 2004 c-diGMP (bis-(3!5)-cyclic di-guanosine monophosphate) is used extensively in bacteria to control biofilm formation and is lately postulated as a novel secondary messenger.
Chan, Carmen
core +1 more source
Investigating the allosteric regulation of YfiN from Pseudomonas aeruginosa: clues from the structure of the catalytic domain. [PDF]
PLoS ONE, 2013 Pseudomonas aeruginosa is responsible for a plethora of biofilm mediated chronic infections among which cystic fibrosis pneumonia is the most frightening. The long-term survival strategy of P.
Giorgio Giardina +6 more
doaj +1 more source
The YfiBNR signal transduction mechanism reveals novel targets for the evolution of persistent Pseudomonas aeruginosa in cystic fibrosis airways [PDF]
, 2012 The genetic adaptation of pathogens in host tissue plays a key role in the establishment of chronic infections. While whole genome sequencing has opened up the analysis of genetic changes occurring during long-term infections, the identification and ...
Tina Jaeger (158216) +48 more
core +1 more source
Cyanobacteriochrome SesA is a diguanylate cyclase that induces cell aggregation in Thermosynechococcus. [PDF]
J Biol Chem, 2014 Cyanobacteria have unique photoreceptors, cyanobacteriochromes, that show diverse spectral properties to sense near-UV/visible lights. Certain cyanobacteriochromes have been shown to regulate cellular phototaxis or chromatic acclimation of photosynthetic pigments.
Enomoto G +5 more
europepmc +4 more sources
Determinants for the Activation and Autoinhibition of the Diguanylate Cyclase Response Regulator WspR [PDF]
Journal of Molecular Biology, 2009 The bacterial second messenger bis-(3'-5')-cyclic dimeric guanosine monophosphate (c-di-GMP) controls secretion, cell adhesion, and motility, leading to biofilm formation and increased cytotoxicity. Diguanylate cyclases containing GGDEF and phosphodiesterases containing EAL or HD-GYP domains have been identified as the enzymes controlling cellular c-di-
Nabanita, De +3 more
openaire +2 more sources