Results 51 to 60 of about 3,724 (177)

Insights into the activation mechanism of PopA, a cyclic di-GMP effector protein involved in cell cycle and development of "Caulobacter Crescentus" [PDF]

, 2012
In Caulobacter crescentus, a complex network integrating cyclic di-GMP and Phosphorylation-dependent signals controls the proteolysis of key regulatory proteins to drive cell cycle and polar morphogenesis.
Schalch-Moser, Annina Larissa
core   +1 more source

Identification of a Diguanylate Cyclase and Its Role in Porphyromonas gingivalis Virulence [PDF]

Infection and Immunity, 2014
ABSTRACT Porphyromonas gingivalis is a Gram-negative obligate anaerobic bacterium and is considered a keystone pathogen in the initiation of periodontitis, one of the most widespread infectious diseases. Bacterial bis-(3′-5′) cyclic GMP (cyclic di-GMP [c-di-GMP]) serves as a second messenger and is involved in ...
Swarnava, Chaudhuri, Siddharth, Pratap, Victor, Paromov, Zhijun, Li, Chinmay K, Mantri, Hua, Xie   +5 more
openaire   +2 more sources

Bi-modal distribution of the second messenger c-di-GMP controls cell fate and asymmetry during the caulobacter cell cycle [PDF]

, 2013
Many bacteria mediate important life-style decisions by varying levels of the second messenger c-di-GMP. Behavioral transitions result from the coordination of complex cellular processes such as motility, surface adherence or the production of virulence ...
Abel, Sören, Bucher, Tabitha, Isabelle Hug (251572), Urs Jenal (37942), Isabelle Hug, Volkhard Kaever, Tabitha Bucher, Pia Abel zur Wiesch (353268), Jenal, U., Sören Abel, Bucher, T., Pia Abel Zur Wiesch, Micaël Nicollier, Micaël Nicollier (454806), Urs Jenal, Volkhard Kaever (152216), Hug, Isabelle, Tabitha Bucher (454805), Sören Abel (454804), Abel Zur Wiesch, P., Kaever, Volkhard, Hug, I., Abel zur Wiesch, Pia, Nicollier, M., Nicollier, Micaël, Abel, S., Jenal, Urs, Kaever, V.   +27 more
core   +1 more source

Analysis of cyclic di-GMP signaling components in "caulobacter crescentus" behavior and cell cycle control [PDF]

, 2013
Cell cycle progression and polar morphogenesis in Caulobacter crescentus are coordinated by the interplay of multiple proteins in time and space. One major regulatory factor is the second messenger cyclic di-GMP (c-di-GMP) therefore especially the ...
Friedrich, Elvira
core   +1 more source

The BDSF quorum sensing receptor RpfR regulates Bep exopolysaccharide synthesis in Burkholderia cenocepacia via interaction with the transcriptional regulator BerB

npj Biofilms and Microbiomes, 2022
The polysaccharide Bep is essential for in vitro biofilm formation of the opportunistic pathogen Burkholderia cenocepacia. We found that the Burkholderia diffusible signaling factor (BDSF) quorum sensing receptor RpfR is a negative regulator of the bep ...
Elisabeth Steiner, Rebecca E. Shilling, Anja M. Richter, Nadine Schmid, Mustafa Fazli, Volkhard Kaever, Urs Jenal, Tim Tolker-Nielsen, Leo Eberl   +8 more
doaj   +1 more source

Specific Control of Pseudomonas aeruginosa Surface-Associated Behaviors by Two c-di-GMP Diguanylate Cyclases

mBio, 2010
The signaling nucleotide cyclic diguanylate (c-di-GMP) regulates the transition between motile and sessile growth in a wide range of bacteria. Understanding how microbes control c-di-GMP metabolism to activate specific pathways is complicated by the ...
Judith H. Merritt, Dae-Gon Ha, Kimberly N. Cowles, Wenyun Lu, Diana K. Morales, Joshua Rabinowitz, Zemer Gitai, George A. O’Toole   +7 more
doaj   +1 more source

TheTreponema denticolaDgcA protein (TDE0125) is a functional diguanylate cyclase

Pathogens and Disease, 2021
ABSTRACTPeriodontal disease (PD) is a progressive inflammatory condition characterized by degradation of the gingival epithelium, periodontal ligament, and alveolar bone ultimately resulting in tooth loss. Treponema denticola is a keystone periopathogen that contributes to immune dysregulation and direct tissue destruction.
Dhara T Patel, Nathaniel S O'Bier, Edward J A Schuler, Richard T Marconi   +3 more
openaire   +2 more sources

PCA‐Based Database Mining Enables the Discovery of Bacterial Carbene Transferases for Stereodivergent Cyclopropanation

Angewandte Chemie, Volume 138, Issue 10, 2 March 2026.
Database mining using principal component analysis (PCA)‐based clustering enabled discovery of bacterial enzymes capable of catalyzing stereodivergent cyclopropanation of styrene. Statistical analyses of sequence data further revealed characteristic structural properties of these enzymes, highlighting the potential of the bioinformatics tools for ...
Shunsuke Kato, Koki Takeuchi, Kohei Umeda, Hisashi Kudo, Tomohisa Hasunuma, Takashi Hayashi   +5 more
wiley   +2 more sources

Phenotypic and integrated analysis of a comprehensive Pseudomonas aeruginosa PAO1 library of mutants lacking cyclic-di-GMP-related genes

Frontiers in Microbiology, 2022
Pseudomonas aeruginosa is a Gram-negative bacterium that is able to survive and adapt in a multitude of niches as well as thrive within many different hosts. This versatility lies within its large genome of ca. 6 Mbp and a tight control in the expression
Kira Eilers, Joey Kuok Hoong Yam, Richard Morton, Adeline Mei Hui Yong, Jaime Brizuela, Jaime Brizuela, Corina Hadjicharalambous, Corina Hadjicharalambous, Xianghui Liu, Michael Givskov, Michael Givskov, Scott A. Rice, Scott A. Rice, Alain Filloux, Alain Filloux   +14 more
doaj   +1 more source

Natural diversity provides a broad spectrum of cyanobacteriochrome-based diguanylate cyclases

Plant Physiology, 2021
Abstract Cyanobacteriochromes (CBCRs) are spectrally diverse photosensors from cyanobacteria distantly related to phytochromes that exploit photoisomerization of linear tetrapyrrole (bilin) chromophores to regulate associated signaling output domains. Unlike phytochromes, a single CBCR domain is sufficient for photoperception.
Matthew Blain-Hartung, Nathan C. Rockwell, J. Clark Lagarias   +2 more
openaire   +2 more sources