Results 51 to 60 of about 40,793 (179)

The YfiBNR signal transduction mechanism reveals novel targets for the evolution of persistent Pseudomonas aeruginosa in cystic fibrosis airways [PDF]

, 2012
The genetic adaptation of pathogens in host tissue plays a key role in the establishment of chronic infections. While whole genome sequencing has opened up the analysis of genetic changes occurring during long-term infections, the identification and ...
Tina Jaeger (158216), Jenal Urs, Jacob G. Malone (158210), Blanka Andrea, Pablo Manfredi, Andrea Blanka, Guy R. Cornelis, Jacob G. Malone, Jaeger Tina, Cornelis Guy R., Bos, R., Manfredi, Pablo, Jacob G Malone, Dötsch, A., Jaeger, T., Blanka, A., Pablo Manfredi (158219), Cornelis, Guy R, Manfredi, P., Bos Raphael, Andrea Blanka (158227), Raphael Bos (158229), Jenal, Urs, Jaeger, Tina, Tina Jaeger, Malone, Jacob G., Urs Jenal (37942), Jenal, U., Blanka, Andrea, Malone Jacob G., Dötsch Andreas, Susanne Häussler (158235), Urs Jenal, Häussler, S., Andreas Dötsch, Cornelis, Guy R., Susanne Häussler, Häussler, Susanne, Manfredi Pablo, Häussler Susanne, Raphael Bos, Guy R. Cornelis (158232), Guy R Cornelis, Malone, Jacob G, Dötsch, Andreas, Cornelis, G. R., Andreas Dötsch (158223), Bos, Raphael, Malone, J. G., Bos R, Cornelis GR, Jenal U, Malone JG, Manfredi P, Jaeger T, Dötsch A, Blanka A, Häussler S   +57 more
core   +1 more source

Determinants for the Activation and Autoinhibition of the Diguanylate Cyclase Response Regulator WspR [PDF]

Journal of Molecular Biology, 2009
The bacterial second messenger bis-(3'-5')-cyclic dimeric guanosine monophosphate (c-di-GMP) controls secretion, cell adhesion, and motility, leading to biofilm formation and increased cytotoxicity. Diguanylate cyclases containing GGDEF and phosphodiesterases containing EAL or HD-GYP domains have been identified as the enzymes controlling cellular c-di-
Nabanita, De, Marcos V A S, Navarro, Rahul V, Raghavan, Holger, Sondermann   +3 more
openaire   +2 more sources

Identification of a Diguanylate Cyclase and Its Role in Porphyromonas gingivalis Virulence [PDF]

Infection and Immunity, 2014
ABSTRACT Porphyromonas gingivalis is a Gram-negative obligate anaerobic bacterium and is considered a keystone pathogen in the initiation of periodontitis, one of the most widespread infectious diseases. Bacterial bis-(3′-5′) cyclic GMP (cyclic di-GMP [c-di-GMP]) serves as a second messenger and is involved in ...
Swarnava, Chaudhuri, Siddharth, Pratap, Victor, Paromov, Zhijun, Li, Chinmay K, Mantri, Hua, Xie   +5 more
openaire   +2 more sources

The BDSF quorum sensing receptor RpfR regulates Bep exopolysaccharide synthesis in Burkholderia cenocepacia via interaction with the transcriptional regulator BerB

npj Biofilms and Microbiomes, 2022
The polysaccharide Bep is essential for in vitro biofilm formation of the opportunistic pathogen Burkholderia cenocepacia. We found that the Burkholderia diffusible signaling factor (BDSF) quorum sensing receptor RpfR is a negative regulator of the bep ...
Elisabeth Steiner, Rebecca E. Shilling, Anja M. Richter, Nadine Schmid, Mustafa Fazli, Volkhard Kaever, Urs Jenal, Tim Tolker-Nielsen, Leo Eberl   +8 more
doaj   +1 more source

Bi-modal distribution of the second messenger c-di-GMP controls cell fate and asymmetry during the caulobacter cell cycle [PDF]

, 2013
Many bacteria mediate important life-style decisions by varying levels of the second messenger c-di-GMP. Behavioral transitions result from the coordination of complex cellular processes such as motility, surface adherence or the production of virulence ...
Abel, Sören, Bucher, Tabitha, Isabelle Hug (251572), Urs Jenal (37942), Isabelle Hug, Volkhard Kaever, Tabitha Bucher, Pia Abel zur Wiesch (353268), Jenal, U., Sören Abel, Bucher, T., Pia Abel Zur Wiesch, Micaël Nicollier, Micaël Nicollier (454806), Urs Jenal, Volkhard Kaever (152216), Hug, Isabelle, Tabitha Bucher (454805), Sören Abel (454804), Abel Zur Wiesch, P., Kaever, Volkhard, Hug, I., Abel zur Wiesch, Pia, Nicollier, M., Nicollier, Micaël, Abel, S., Jenal, Urs, Kaever, V., Sören Abel, Nicollier M, Abel S, Bucher T, Hug I, Jenal U, Kaever V, Abel Zur Wiesch P   +35 more
core   +2 more sources

Diguanylate Cyclase Activation: It Takes Two [PDF]

Structure, 2007
Characterization of an activated diguanylate cyclase reported in this issue of Structure by Wassmann et al. (2007) reveals how phosphorylation promotes dimerization necessary for synthesis of the second messenger c-di-GMP, establishes the catalytic mechanism, and identifies a widely conserved mode of product inhibition.
openaire   +1 more source

Insights into the activation mechanism of PopA, a cyclic di-GMP effector protein involved in cell cycle and development of "Caulobacter Crescentus" [PDF]

, 2012
In Caulobacter crescentus, a complex network integrating cyclic di-GMP and Phosphorylation-dependent signals controls the proteolysis of key regulatory proteins to drive cell cycle and polar morphogenesis.
Schalch-Moser, Annina Larissa
core   +1 more source

Specific Control of Pseudomonas aeruginosa Surface-Associated Behaviors by Two c-di-GMP Diguanylate Cyclases

mBio, 2010
The signaling nucleotide cyclic diguanylate (c-di-GMP) regulates the transition between motile and sessile growth in a wide range of bacteria. Understanding how microbes control c-di-GMP metabolism to activate specific pathways is complicated by the ...
Judith H. Merritt, Dae-Gon Ha, Kimberly N. Cowles, Wenyun Lu, Diana K. Morales, Joshua Rabinowitz, Zemer Gitai, George A. O’Toole   +7 more
doaj   +1 more source

Phenotypic and integrated analysis of a comprehensive Pseudomonas aeruginosa PAO1 library of mutants lacking cyclic-di-GMP-related genes

Frontiers in Microbiology, 2022
Pseudomonas aeruginosa is a Gram-negative bacterium that is able to survive and adapt in a multitude of niches as well as thrive within many different hosts. This versatility lies within its large genome of ca. 6 Mbp and a tight control in the expression
Kira Eilers, Joey Kuok Hoong Yam, Richard Morton, Adeline Mei Hui Yong, Jaime Brizuela, Jaime Brizuela, Corina Hadjicharalambous, Corina Hadjicharalambous, Xianghui Liu, Michael Givskov, Michael Givskov, Scott A. Rice, Scott A. Rice, Alain Filloux, Alain Filloux   +14 more
doaj   +1 more source

Cyclic‐di‐GMP signalling and biofilm‐related properties of the Shiga toxin‐producing 2011 German outbreak Escherichia coli O104:H4

EMBO Molecular Medicine, 2014
In 2011, nearly 4,000 people in Germany were infected by Shiga toxin (Stx)‐producing Escherichia coli O104:H4 with > 22% of patients developing haemolytic uraemic syndrome (HUS).
Anja M Richter, Tatyana L Povolotsky, Lothar H Wieler, Regine Hengge   +3 more
doaj   +1 more source