Results 61 to 70 of about 3,724 (177)

Cyclic‐di‐GMP signalling and biofilm‐related properties of the Shiga toxin‐producing 2011 German outbreak Escherichia coli O104:H4

EMBO Molecular Medicine, 2014
In 2011, nearly 4,000 people in Germany were infected by Shiga toxin (Stx)‐producing Escherichia coli O104:H4 with > 22% of patients developing haemolytic uraemic syndrome (HUS).
Anja M Richter, Tatyana L Povolotsky, Lothar H Wieler, Regine Hengge   +3 more
doaj   +1 more source

Bacterial cyclic diguanylate signaling networks sense temperature

, 2021
Many bacteria use the second messenger cyclic diguanylate (c-di-GMP) to control motility, biofilm production and virulence. Here, we identify a thermosensory diguanylate cyclase (TdcA) that modulates temperature-dependent motility, biofilm development ...
Singh, Manu, Nicolas Fournier, Julie Groizeleau, Justin L. MacCallum, Joe Jonathan Harrison, Jennings, Laura K., Good, Nathan M., Ian A. Lewis, Weerayuth Kittichotirat, Singletary, Larissa A., Ann Karen Cornelia Brassinga, Ayush Kumar, MacCallum, Justin L., Lou, Yuefei, Maria Silvina Stietz, Rich, Jacquelyn D., Bryan G. Yipp, Stietz, Maria Silvina, Bumgarner, Roger E., Hynes, Michael F., Trevor E. Randall, Fournier, Nicolas, Kumar, Ayush, Elise Granton, Groves, Ryan A., Yipp, Bryan G., Randall, Trevor E., Katherine Leblanc, Fanny Liu, Kittichotirat, Weerayuth, Boo Shan Tseng, Parsek, Matthew R., Jacquelyn D. Rich, Roger E. Bumgarner, Fiona S. L. Brinkman, Brinkman, Fiona S.L., Tseng, Boo Shan, Yuefei Lou, Laura K. Jennings, Emily Au, Winsor, Geoffrey L., Matthew R. Parsek, Au, Emily, Almblad, Henrik, Nathan M. Good, Larissa A. Singletary, Groizeleau, Julie, Henrik Almblad, Michael F. Hynes, Manu Singh, Harrison, Joe Jonathan, Liu, Fanny, Brassinga, Ann Karen Cornelia, Leblanc, Katherine, Lewis, Ian A., Geoffrey L. Winsor, Granton, Elise, Tara M. L. Winstone, Winstone, Tara M.L., Ryan A. Groves   +59 more
core   +1 more source

Characterization of a Diguanylate Cyclase VAGM001033 of Vibrio alginolyticus and Protective Efficacy as a Live Attenuated Vaccine Candidate in Pearl Gentian Grouper

Frontiers in Marine Science, 2022
Vibrio alginolyticus (V. alginolyticus) is one of the important epizootic pathogens in marine animals. VAGM001033 belongs to a diguanylate cyclase, responsible for the synthesis of dimeric guanosine monophosphate (c-di-GMP), a ubiquitous second messenger
Huiming Tan, Fan Da, Guixiang Lin, Xiaoju Wan, Jichang Jian, Jichang Jian, Shuanghu Cai, Shuanghu Cai   +7 more
doaj   +1 more source

Formation and dimerization of the phosphodiesterase active site of the Pseudomonas aeruginosa MorA, a bi-functional c-di-GMP regulator

, 2014
Diguanylate cyclases (DGC) and phosphodiesterases (PDE) respectively synthesise and hydrolyse the secondary messenger cyclic dimeric GMP (c-di-GMP), and both activities are often found in a single protein.
Mikolajek, Halina, Keevil, Charles William, Schlaefli, Henry George, Webb, Jeremy Stephen, Tews, Ivo, Phippen, Curtis William   +5 more
core   +1 more source

Ligand binding represses bacterial histidine kinase activity by inhibiting its dimerization

The FEBS Journal, EarlyView.
PdtaS is a kinase in the pathogen Mycobacterium tuberculosis that senses copper and nitric oxide and controls virulence gene expression, but how the kinase senses these compounds was unclear. We show that PdtaS is active as a dimer with each monomer phosphorylating the other in trans.
Gaurav D. Sankhe, Jiawei Xing, Xiansha Xiao, John A. Buglino, Huilin Li, Igor B. Zhulin, Michael S. Glickman   +6 more
wiley   +1 more source

Naturally Occurring CodY Variants Alter Ligand Binding, DNA Target Affinity, and Virulence in Clostridioides difficile

Molecular Microbiology, EarlyView.
Single amino acid substitutions in the global regulator CodY can alter nutrient sensing and virulence regulation in Clostridioides difficile. We show that the CodY(Y146N) and CodY(V58A) variants display altered ligand binding and reduced promoter binding, leading to derepression of toxin regulatory pathways and increased virulence in vivo.
Md Kamrul Hasan, Sourav Roy, Revathi Govind   +2 more
wiley   +1 more source

To Move or Not to Move: When and How Bacteria Suppress Flagellar Motility

Molecular Microbiology, EarlyView.
Motility cessation in bacteria is a key regulatory strategy that provides multiple survival advantages including enhanced community cooperation, niche adaptation and evasion of host immune responses. This process is controlled by associated mechanisms such as post‐translational modifications and second messenger signalling that stabilise non‐motile ...
Fatemeh Mohaghegh, Jacob Scadden, Matthew A. B. Baker   +2 more
wiley   +1 more source

Bordetella bronchiseptica Diguanylate Cyclase BdcA Regulates Motility and Is Important for the Establishment of Respiratory Infection in Mice. [PDF]

J Bacteriol, 2019
Bacteria can be motile and planktonic or, alternatively, sessile and participating in the biofilm mode of growth. The transition between these lifestyles can be regulated by a second messenger, cyclic dimeric GMP (c-di-GMP).
Belhart K, Gutierrez MP, Zacca F, Ambrosis N, Cartelle Gestal M, Taylor D, Dahlstrom KM, Harvill ET, O'Toole GA, Sisti F, Fernández J.   +10 more
europepmc   +2 more sources

Forecasting Root Rot Disease through Predictive Microbial Functional Profiling

Advanced Science, Volume 13, Issue 23, 23 April 2026.
Predicting soil‐borne disease moves beyond observation with a framework that elevates microbial functional genes into reliable forecasting biomarkers. By coupling targeted qPCR assays for core stress‐response genes with machine learning, this method detects root rot risks in pre‐symptomatic soils with over 80% accuracy.
Chuan You, Peng Ren, Ying Guan, Kai Gong, Zhen Hua, Wuxian Zhou, Xinlan Mei, Yikui Wang, Xiaofang Wang, Yangchun Xu, Qirong Shen, Zhong Wei   +11 more
wiley   +1 more source

The MarR Family Transcriptional Regulator EmrR Negatively Regulates the Type III Secretion System (T3SS) and Positively Modulates Pathogenicity in Dickeya oryzae

Molecular Plant Pathology, Volume 27, Issue 4, April 2026.
This study revealed that the transcriptional regulator EmrR in Dickeya oryzae modulates virulence by regulating hrpL expression and c‐di‐GMP levels. It affects motility, biofilm formation, cellulase production and pathogenicity. EMSA and footprinting confirmed EmrR binds directly to the promoter of its target operon.
Mingfa Lv, Wenqi Huang, Ziwei Meng, Xiaojing Fan, Peng Li, Zeling Xu, Shaohua Chen, Xiaoyuan Chen, Jianuan Zhou, Lianhui Zhang, Yingying Cheng, Tao Zhuo, Ming Hu   +12 more
wiley   +1 more source