Results 61 to 70 of about 35,352 (121)

To Move or Not to Move: When and How Bacteria Suppress Flagellar Motility

Molecular Microbiology, Volume 126, Issue 2, Page 173-189, August 2026.
Motility cessation in bacteria is a key regulatory strategy that provides multiple survival advantages including enhanced community cooperation, niche adaptation and evasion of host immune responses. This process is controlled by associated mechanisms such as post‐translational modifications and second messenger signalling that stabilise non‐motile ...
Fatemeh Mohaghegh, Jacob Scadden, Matthew A. B. Baker   +2 more
wiley   +1 more source

Oxygen promotes biofilm formation of Shewanella putrefaciens CN32 through a diguanylate cyclase and an adhesin [PDF]

, 2013
Although oxygen has been reported to regulate biofilm formation by several Shewanella species, the exact regulatory mechanism mostly remains unclear. Here, we identify a direct oxygen-sensing diguanylate cyclase (DosD) and reveal its regulatory role in ...
Zhou, Xian-Xuan, Wu, Chao, Song, Xiang-Ning, Yin, Hao, Han, Jun-Cheng, Li, Wen-Wei, Yu, Han-Qing, Zhao, Li-Ping, Tian, Li-Jiao, Cheng, Yuan-Yuan   +9 more
core   +1 more source

Naturally Occurring CodY Variants Alter Ligand Binding, DNA Target Affinity, and Virulence in Clostridioides difficile

Molecular Microbiology, Volume 126, Issue 1, Page 98-110, July 2026.
Single amino acid substitutions in the global regulator CodY can alter nutrient sensing and virulence regulation in Clostridioides difficile. We show that the CodY(Y146N) and CodY(V58A) variants display altered ligand binding and reduced promoter binding, leading to derepression of toxin regulatory pathways and increased virulence in vivo.
Md Kamrul Hasan, Sourav Roy, Revathi Govind   +2 more
wiley   +1 more source

An evolutionary optimization of a rhodopsin-based phototrophic metabolism in Escherichia coli

Microbial Cell Factories, 2017
Background The expression of the Gloeobacter rhodopsin (GR) in a chemotrophic Escherichia coli enables the light-driven phototrophic energy generation. Adaptive laboratory evolution has been used for acquiring desired phenotype of microbial cells and for
Hyun Aaron Kim, Hyun Ju Kim, Jihoon Park, Ah Reum Choi, Kyoo Heo, Haeyoung Jeong, Kwang-Hwan Jung, Yeong-Jae Seok, Pil Kim, Sang Jun Lee   +9 more
doaj   +1 more source

Forecasting Root Rot Disease through Predictive Microbial Functional Profiling

Advanced Science, Volume 13, Issue 23, 23 April 2026.
Predicting soil‐borne disease moves beyond observation with a framework that elevates microbial functional genes into reliable forecasting biomarkers. By coupling targeted qPCR assays for core stress‐response genes with machine learning, this method detects root rot risks in pre‐symptomatic soils with over 80% accuracy.
Chuan You, Peng Ren, Ying Guan, Kai Gong, Zhen Hua, Wuxian Zhou, Xinlan Mei, Yikui Wang, Xiaofang Wang, Yangchun Xu, Qirong Shen, Zhong Wei   +11 more
wiley   +1 more source

Serine Hydroxymethyltransferase ShrA (PA2444) Controls Rugose Small-Colony Variant Formation in Pseudomonas aeruginosa

Frontiers in Microbiology, 2018
Pseudomonas aeruginosa causes many biofilm infections, and the rugose small-colony variants (RSCVs) of this bacterium are important for infection. We found here that inactivation of PA2444, which we determined to be a serine hydroxymethyltransferase ...
Mingming Pu, Lili Sheng, Sooyeon Song, Ting Gong, Thomas K. Wood   +4 more
doaj   +1 more source

Evaluation and characterization of the predicted diguanylate cyclase‐encoding genes in Pseudomonas aeruginosa

MicrobiologyOpen, 2020
Opportunistic pathogen Pseudomonas aeruginosa can cause acute and chronic infections in humans. It is notorious for its resistance to antibiotics due to the formation of biofilms.
Pramod Bhasme, Qing Wei, Anming Xu, Syed Tatheer Alam Naqvi, Di Wang, Luyan Z. Ma   +5 more
doaj   +1 more source

The MarR Family Transcriptional Regulator EmrR Negatively Regulates the Type III Secretion System (T3SS) and Positively Modulates Pathogenicity in Dickeya oryzae

Molecular Plant Pathology, Volume 27, Issue 4, April 2026.
This study revealed that the transcriptional regulator EmrR in Dickeya oryzae modulates virulence by regulating hrpL expression and c‐di‐GMP levels. It affects motility, biofilm formation, cellulase production and pathogenicity. EMSA and footprinting confirmed EmrR binds directly to the promoter of its target operon.
Mingfa Lv, Wenqi Huang, Ziwei Meng, Xiaojing Fan, Peng Li, Zeling Xu, Shaohua Chen, Xiaoyuan Chen, Jianuan Zhou, Lianhui Zhang, Yingying Cheng, Tao Zhuo, Ming Hu   +12 more
wiley   +1 more source

Expanded Functional Characterization and Optimization of Protein Expression in Treponema denticola Shuttle Plasmids

Molecular Oral Microbiology, Volume 41, Issue 2, Page 69-84, April 2026.
We report optimization of the Treponema denticola shuttle plasmid system by minimizing its size and by characterizing an array of promoter‐gene constructs for genetic complementation, including the first use in Treponema of a Tet‐inducible system for controlled expression of potentially toxic genes.
M. Paula Goetting‐Minesky, Valentina Godovikova, Prakaimuk Saraithong, Alexander H. Rickard, Brigette R. Crawley, Sara M. Agolli, Reagan L. Boyce, Trishna L. Appaji, J. Christopher Fenno   +8 more
wiley   +1 more source

Molecular analysis of mammalian adenylyl cyclases and bacterial adenylyl cyclase toxins [PDF]

, 2009
The cAMP signaling pathway is crucial for many physiological processes and many disease states like neurodegenerative diseases, mood disorders, pain, drug dependency or heart failure.
Göttle, Martin
core   +1 more source